Cloned (Comment) | Organism |
---|---|
- |
Staphylococcus aureus |
- |
Mycobacterium tuberculosis |
Crystallization (Comment) | Organism |
---|---|
- |
Escherichia coli |
- |
Mycobacterium tuberculosis |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
CoA | competitive | Escherichia coli | |
additional information | inhibition by CoA thioesters | Escherichia coli |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.027 | - |
ATP | - |
Staphylococcus aureus | |
0.093 | - |
pantothenate | - |
Staphylococcus aureus | |
0.136 | - |
pantothenate | - |
Escherichia coli |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + pantothenate | Escherichia coli | first step of the pathway from pantothenate to CoA. The activity of this protein is tightly regulated by CoA feedback inhibition, both in vitro and in vivo | ADP + (R)-4'-phosphopantothenate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
Mycobacterium tuberculosis | - |
- |
- |
Staphylococcus aureus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Staphylococcus aureus |
- |
Mycobacterium tuberculosis |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + pantothenate | - |
Staphylococcus aureus | ADP + (R)-4'-phosphopantothenate | - |
? | |
ATP + pantothenate | - |
Escherichia coli | ADP + (R)-4'-phosphopantothenate | - |
? | |
ATP + pantothenate | - |
Mycobacterium tuberculosis | ADP + (R)-4'-phosphopantothenate | - |
? | |
ATP + pantothenate | first step of the pathway from pantothenate to CoA. The activity of this protein is tightly regulated by CoA feedback inhibition, both in vitro and in vivo | Escherichia coli | ADP + (R)-4'-phosphopantothenate | - |
? | |
ATP + pantothenate | - |
Mycobacterium tuberculosis | ADP + D-4'-phosphopantothenate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CoaA | - |
Staphylococcus aureus |
CoaA | - |
Escherichia coli |
CoaA | - |
Mycobacterium tuberculosis |
PanK | - |
Staphylococcus aureus |
PanK | - |
Escherichia coli |
PanK | - |
Mycobacterium tuberculosis |