BRENDA - Enzyme Database show
show all sequences of 2.7.1.33

Characterization of a new pantothenate kinase isoform from Helicobacter pylori

Brand, L.A.; Strauss, E.; J. Biol. Chem. 280, 20185-20188 (2005)

Data extracted from this reference:

Activating Compound
Activating Compound
Commentary
Organism
Structure
additional information
enzyme is not affected by CoA or acetyl-CoA
Bacillus subtilis
additional information
enzyme is not affected by CoA or acetyl-CoA
Helicobacter pylori
Cloned(Commentary)
Commentary
Organism
gene coaX, gene cluster analysis, DNA and amino acid sequence determination and analysis, overexpression of N-terminally His6-tagged in Escherichia coli strain BL21(DE3)
Bacillus subtilis
gene coaX, gene cluster analysis, DNA and amino acid sequence determination and analysis, overexpression of N-terminally His6-tagged in Escherichia coli strain BL21(DE3)
Helicobacter pylori
Inhibitors
Inhibitors
Commentary
Organism
Structure
additional information
no inhibition by N-pentylpantothenamide, enzyme is not affected by CoA or acetyl-CoA
Bacillus subtilis
additional information
no inhibition by N-pentylpantothenamide, enzyme is not affected by CoA or acetyl-CoA
Helicobacter pylori
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.101
-
(R)-pantothenate
pH 7.6, 25°C
Helicobacter pylori
0.168
-
(R)-pantothenate
pH 7.6, 25°C
Bacillus subtilis
3.05
-
ATP
pH 7.6, 25°C
Bacillus subtilis
9.59
-
ATP
pH 7.6, 25°C
Helicobacter pylori
Metals/Ions
Metals/Ions
Commentary
Organism
Structure
KCl
-
Bacillus subtilis
KCl
-
Helicobacter pylori
Mg2+
-
Bacillus subtilis
Mg2+
-
Helicobacter pylori
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ATP + (R)-pantothenate
Bacillus subtilis
first step in coenzyme A biosynthesis
ADP + (R)-4'-phosphopantothenate
-
-
?
ATP + (R)-pantothenate
Helicobacter pylori
first step in coenzyme A biosynthesis
ADP + (R)-4'-phosphopantothenate
-
-
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Bacillus subtilis
-
gene coaX
-
Helicobacter pylori
p37564
gene coaX
-
Purification (Commentary)
Commentary
Organism
recombinant N-terminally His6-tagged enzyme from Escherichia coli strain BL21(DE3) by nickel affinity chromatography
Bacillus subtilis
recombinant N-terminally His6-tagged enzyme from Escherichia coli strain BL21(DE3) by nickel affinity chromatography
Helicobacter pylori
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ATP + (R)-pantothenate
-
662369
Helicobacter pylori
ADP + (R)-4'-phosphopantothenate
-
-
-
?
ATP + (R)-pantothenate
first step in coenzyme A biosynthesis
662369
Bacillus subtilis
ADP + (R)-4'-phosphopantothenate
-
-
-
?
ATP + (R)-pantothenate
first step in coenzyme A biosynthesis
662369
Helicobacter pylori
ADP + (R)-4'-phosphopantothenate
-
-
-
?
ATP + (R)-pantothenate
the enzyme is absolutely specific for ATP, no activity with CTP, GTP, UTP, or phosphoenolpyruvate as phosphoryl donors
662369
Bacillus subtilis
ADP + (R)-4'-phosphopantothenate
-
-
-
?
CTP + (R)-pantothenate
-
662369
Helicobacter pylori
CDP + (R)-4'-phosphopantothenate
-
-
-
?
GTP + (R)-pantothenate
-
662369
Helicobacter pylori
GDP + (R)-4'-phosphopantothenate
-
-
-
?
additional information
N-pentylpantothenate is no substrate
662369
Bacillus subtilis
?
-
-
-
-
additional information
N-pentylpantothenate is no substrate, no activity with UTP or phosphoenolpyruvate as phosphoryl donors
662369
Helicobacter pylori
?
-
-
-
-
Temperature Optimum [°C]
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
25
-
assay at
Bacillus subtilis
25
-
assay at
Helicobacter pylori
Turnover Number [1/s]
Turnover Number Minimum [1/s]
Turnover Number Maximum [1/s]
Substrate
Commentary
Organism
Structure
2.09
-
ATP
pH 7.6, 25°C
Helicobacter pylori
2.09
-
(R)-pantothenate
pH 7.6, 25°C
Helicobacter pylori
2.12
-
ATP
pH 7.6, 25°C
Bacillus subtilis
2.12
-
(R)-pantothenate
pH 7.6, 25°C
Bacillus subtilis
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
7.6
-
assay at
Bacillus subtilis
7.6
-
assay at
Helicobacter pylori
Cofactor
Cofactor
Commentary
Organism
Structure
ATP
absolutely specific for
Bacillus subtilis
ATP
can partially be substituted by CTP or GTP
Helicobacter pylori
CTP
less active than ATP
Helicobacter pylori
GTP
less active than ATP
Helicobacter pylori
Activating Compound (protein specific)
Activating Compound
Commentary
Organism
Structure
additional information
enzyme is not affected by CoA or acetyl-CoA
Bacillus subtilis
additional information
enzyme is not affected by CoA or acetyl-CoA
Helicobacter pylori
Cloned(Commentary) (protein specific)
Commentary
Organism
gene coaX, gene cluster analysis, DNA and amino acid sequence determination and analysis, overexpression of N-terminally His6-tagged in Escherichia coli strain BL21(DE3)
Bacillus subtilis
gene coaX, gene cluster analysis, DNA and amino acid sequence determination and analysis, overexpression of N-terminally His6-tagged in Escherichia coli strain BL21(DE3)
Helicobacter pylori
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
ATP
absolutely specific for
Bacillus subtilis
ATP
can partially be substituted by CTP or GTP
Helicobacter pylori
CTP
less active than ATP
Helicobacter pylori
GTP
less active than ATP
Helicobacter pylori
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
additional information
no inhibition by N-pentylpantothenamide, enzyme is not affected by CoA or acetyl-CoA
Bacillus subtilis
additional information
no inhibition by N-pentylpantothenamide, enzyme is not affected by CoA or acetyl-CoA
Helicobacter pylori
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.101
-
(R)-pantothenate
pH 7.6, 25°C
Helicobacter pylori
0.168
-
(R)-pantothenate
pH 7.6, 25°C
Bacillus subtilis
3.05
-
ATP
pH 7.6, 25°C
Bacillus subtilis
9.59
-
ATP
pH 7.6, 25°C
Helicobacter pylori
Metals/Ions (protein specific)
Metals/Ions
Commentary
Organism
Structure
KCl
-
Bacillus subtilis
KCl
-
Helicobacter pylori
Mg2+
-
Bacillus subtilis
Mg2+
-
Helicobacter pylori
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ATP + (R)-pantothenate
Bacillus subtilis
first step in coenzyme A biosynthesis
ADP + (R)-4'-phosphopantothenate
-
-
?
ATP + (R)-pantothenate
Helicobacter pylori
first step in coenzyme A biosynthesis
ADP + (R)-4'-phosphopantothenate
-
-
?
Purification (Commentary) (protein specific)
Commentary
Organism
recombinant N-terminally His6-tagged enzyme from Escherichia coli strain BL21(DE3) by nickel affinity chromatography
Bacillus subtilis
recombinant N-terminally His6-tagged enzyme from Escherichia coli strain BL21(DE3) by nickel affinity chromatography
Helicobacter pylori
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ATP + (R)-pantothenate
-
662369
Helicobacter pylori
ADP + (R)-4'-phosphopantothenate
-
-
-
?
ATP + (R)-pantothenate
first step in coenzyme A biosynthesis
662369
Bacillus subtilis
ADP + (R)-4'-phosphopantothenate
-
-
-
?
ATP + (R)-pantothenate
first step in coenzyme A biosynthesis
662369
Helicobacter pylori
ADP + (R)-4'-phosphopantothenate
-
-
-
?
ATP + (R)-pantothenate
the enzyme is absolutely specific for ATP, no activity with CTP, GTP, UTP, or phosphoenolpyruvate as phosphoryl donors
662369
Bacillus subtilis
ADP + (R)-4'-phosphopantothenate
-
-
-
?
CTP + (R)-pantothenate
-
662369
Helicobacter pylori
CDP + (R)-4'-phosphopantothenate
-
-
-
?
GTP + (R)-pantothenate
-
662369
Helicobacter pylori
GDP + (R)-4'-phosphopantothenate
-
-
-
?
additional information
N-pentylpantothenate is no substrate
662369
Bacillus subtilis
?
-
-
-
-
additional information
N-pentylpantothenate is no substrate, no activity with UTP or phosphoenolpyruvate as phosphoryl donors
662369
Helicobacter pylori
?
-
-
-
-
Temperature Optimum [°C] (protein specific)
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
25
-
assay at
Bacillus subtilis
25
-
assay at
Helicobacter pylori
Turnover Number [1/s] (protein specific)
Turnover Number Minimum [1/s]
Turnover Number Maximum [1/s]
Substrate
Commentary
Organism
Structure
2.09
-
ATP
pH 7.6, 25°C
Helicobacter pylori
2.09
-
(R)-pantothenate
pH 7.6, 25°C
Helicobacter pylori
2.12
-
ATP
pH 7.6, 25°C
Bacillus subtilis
2.12
-
(R)-pantothenate
pH 7.6, 25°C
Bacillus subtilis
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
7.6
-
assay at
Bacillus subtilis
7.6
-
assay at
Helicobacter pylori
Other publictions for EC 2.7.1.33
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
738773
Ogata
Prokaryotic type III pantothen ...
Escherichia coli
J. Gen. Appl. Microbiol.
61
266-269
2016
-
-
1
-
-
-
-
-
-
-
-
1
-
2
-
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1
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1
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1
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-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
737839
Awuah
Exploring structural motifs ne ...
Escherichia coli
Bioorg. Med. Chem.
22
3083-3090
2014
-
-
-
-
-
-
-
28
-
-
-
1
-
3
-
-
-
-
-
-
-
-
28
-
-
-
-
28
-
-
-
-
-
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-
-
-
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-
-
28
-
-
-
1
-
-
-
-
-
-
-
-
28
-
-
-
-
28
-
-
-
-
-
-
-
-
28
28
737966
Ogata
Role of prokaryotic type I and ...
Bacillus subtilis
Can. J. Microbiol.
60
297-305
2014
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
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1
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1
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-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
739613
Hughes
Structural characterization of ...
Klebsiella pneumoniae, Klebsiella pneumoniae 342, Staphylococcus aureus, Staphylococcus aureus MSSA476
Proteins
82
1542-1548
2014
-
-
2
2
-
-
-
-
-
-
-
4
-
7
-
-
2
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
2
-
-
-
-
-
-
-
-
-
4
-
-
-
2
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
738582
Bjoerkelid
Structural and biochemical cha ...
Mycobacterium tuberculosis
J. Biol. Chem.
288
18260-18270
2013
-
-
1
1
-
-
7
-
-
-
-
1
-
4
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
7
-
-
-
-
-
1
-
-
-
1
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
739611
Li
Crystal structures of Klebsiel ...
Klebsiella pneumoniae, Klebsiella pneumoniae 342
Proteins
81
1466-1472
2013
-
-
1
1
-
-
-
-
-
-
-
2
-
5
-
-
1
-
-
-
-
-
2
-
-
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-
-
-
-
-
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1
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1
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2
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1
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-
2
-
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-
-
-
-
-
-
-
-
-
-
-
-
-
722830
Venkatraman
Screening, identification, and ...
Mycobacterium tuberculosis
J. Biomol. Screen.
17
293-302
2012
-
-
1
-
-
-
6
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
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-
7
-
-
1
-
-
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7
6
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1
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-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
727436
Ishibashi
A detailed biochemical charact ...
Thermococcus kodakarensis
Extremophiles
16
819-828
2012
-
-
1
-
-
-
3
-
-
-
-
1
-
4
-
-
1
-
-
-
-
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1
-
1
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1
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1
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-
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3
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1
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1
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-
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-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
721160
Chetnani
Location and conformation of p ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
Acta Crystallogr. Sect. D
67
774-783
2011
-
-
1
1
-
-
-
-
-
-
-
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-
6
-
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1
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2
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1
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1
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1
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-
2
-
-
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-
-
-
-
-
-
-
-
-
-
-
704326
Takagi
Pantothenate kinase from the t ...
Picrophilus torridus
J. Bacteriol.
192
233-241
2010
-
-
1
-
-
-
-
2
1
2
1
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-
7
-
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1
-
-
-
1
-
1
1
1
1
-
2
1
1
-
-
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-
-
1
-
-
-
-
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-
2
1
2
1
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-
-
1
-
-
1
-
1
1
1
1
-
2
1
1
-
-
-
-
-
-
-
-
722018
Leonardi
Modulation of pantothenate kin ...
Homo sapiens
Chem. Biol.
17
892-902
2010
7
-
-
-
4
-
28
2
-
-
-
-
-
2
-
-
-
-
-
1
-
-
2
-
-
-
-
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-
-
-
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-
-
19
8
-
-
-
-
4
-
19
29
-
2
-
-
-
-
-
-
-
-
-
2
-
-
2
-
-
-
-
-
-
-
-
-
-
1
2
-
-
-
722262
Gutierrez
Zinc accumulation in heterozyg ...
Drosophila melanogaster
FEBS Lett.
584
2942-2946
2010
-
-
-
-
-
-
-
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-
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4
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1
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1
-
-
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-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
722932
Mandakh
Identification and characteriz ...
Streptomyces peucetius, Streptomyces peucetius ATCC 27952
J. Microbiol. Biotechnol.
20
1689-1695
2010
-
-
1
-
-
-
-
-
-
-
2
-
-
6
-
-
1
-
-
-
-
-
2
1
-
1
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
1
-
-
-
-
2
1
-
1
-
-
1
-
-
-
-
-
-
-
-
-
722968
Chetnani
M. tuberculosis pantothenate k ...
Mycobacterium tuberculosis
J. Mol. Biol.
400
171-185
2010
-
-
1
1
-
-
-
2
-
-
-
-
-
3
-
-
1
-
-
-
-
-
2
-
-
-
-
2
-
-
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-
-
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1
-
1
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2
-
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-
1
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-
-
2
-
-
-
-
2
-
-
-
-
-
-
-
-
2
2
723121
Awasthy
Essentiality and functional an ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (ATCC 27294)
Microbiology
156
2691-2701
2010
-
-
1
-
-
-
-
-
-
-
-
-
-
9
-
-
1
-
-
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Pantothenate kinase 1 is requi ...
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Mycobacterium tuberculosis pan ...
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Characterization and kinetics ...
Enterococcus faecalis
Biochemistry
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Genetic analysis of coenzyme A ...
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Pantothenate kinase-associated ...
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Siblings with the adult-onset ...
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Nucleoside triphosphate mimicr ...
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Isaac
Pallidal stimulation for panto ...
Homo sapiens
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Yang
Structural basis for substrate ...
Helicobacter pylori, Thermotoga maritima
Biochemistry
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2
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686546
Mikati
Deep brain stimulation as a mo ...
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Eur. J. Paediatr. Neurol.
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Spry
Coenzyme A biosynthesis: an an ...
Escherichia coli, Mycobacterium tuberculosis, Staphylococcus aureus
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Chan
Pantothenate kinase-associated ...
Homo sapiens
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Bosveld
De novo CoA biosynthesis is re ...
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Paige
The type III pantothenate kina ...
Bacillus anthracis
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Ellers
Temperature-induced gene expre ...
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310
137-147
2008
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689108
Lyoo
Anticholinergic-responsive gai ...
Homo sapiens
Mov. Disord.
23
283-284
2008
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689193
McNeill
T2* and FSE MRI distinguishes ...
Homo sapiens
Neurology
70
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2008
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690187
Marquez
Neuropathologic findings in an ...
Gorilla beringei
Vet. Pathol.
45
531-537
2008
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672234
Nicely
Structure of the type III pant ...
Bacillus anthracis
Biochemistry
46
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2007
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673027
Zhang
Chemical knockout of pantothen ...
Mus musculus
Chem. Biol.
14
291-302
2007
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Lehane
Feedback inhibition of pantoth ...
Plasmodium falciparum
J. Biol. Chem.
282
25395-25405
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676884
Leonardi
Activation of human mitochondr ...
Homo sapiens
Proc. Natl. Acad. Sci. USA
104
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677979
Kumar
How pantothenol intervenes in ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
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361
903-909
2007
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684227
Clement
Neurodegeneration with brain i ...
Homo sapiens
Acta Neurol. Belg.
107
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2007
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686741
Leonardi
Localization and regulation of ...
Homo sapiens, Mus musculus
FEBS Lett.
581
4639-4644
2007
2
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2
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687612
Hong
Crystal structures of human pa ...
Homo sapiens
J. Biol. Chem.
282
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2007
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2
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2
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2
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2
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2
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4
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687943
Kazek
A novel PANK2 gene mutation: c ...
Homo sapiens
J. Child Neurol.
22
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2007
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1
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1
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688176
Kuo
Deprivation of pantothenic aci ...
Mus musculus
J. Inherit. Metab. Dis.
30
310-317
2007
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1
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688202
Freeman
Intellectual and adaptive beha ...
Homo sapiens
J. Intellect. Disabil. Res.
51
417-426
2007
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689010
Wilfred
Energizing miRNA research: a r ...
Homo sapiens
Mol. Genet. Metab.
91
209-217
2007
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1
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4
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1
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1
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Iron toxicity as a potential f ...
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1
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2
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5
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1
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1
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2
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1
2
1
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2
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1
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1
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2
1
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Hartig
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1
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1
1
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2
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1
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1
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1
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1
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1
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1
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3
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2
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1
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1
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1
1
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1
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2
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Hong
Prokaryotic type II and type I ...
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8
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Expression, purification, crys ...
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1
1
1
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1
2
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1
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4
1
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A class of pantothenic acid an ...
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13
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4
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4
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1
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1
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1
1
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1
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5
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4
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1
2
1
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1
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1
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1
1
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3
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2
1
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4
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1
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10
1
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Kotzbauer
Altered neuronal mitochondrial ...
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1
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2
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1
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Mitochondrial localization of ...
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1
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1
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1
1
1
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4
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3
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1
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1
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1
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1
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Choudhry
Inhibitors of pantothenate kin ...
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2003
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1
1
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1
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-
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1
1
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2
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1
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1
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1
1
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Rock
Role of feedback regulation of ...
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3
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3
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Rock
The murine pantothenate kinase ...
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1
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2
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2
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1
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2
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-
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641401
Afshar
Fumble encodes a pantothenate ...
Drosophila melanogaster
Genetics
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1
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1
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1
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2
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1
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641396
Yun
Structural basis for the feedb ...
Escherichia coli
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1
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1
1
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1
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1
1
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641397
Rock
Pantothenate kinase regulation ...
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1
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3
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1
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641402
Calder
Cloning and characterization o ...
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1
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Vallari
Regulation of pantothenate kin ...
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641394
Halvorsen
-
Multiple molecular forms of ra ...
Rattus norvegicus
Scand. J. Clin. Lab. Invest.
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1986
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641391
Fisher
The properties and regulation ...
Rattus norvegicus, Rattus norvegicus Sprague-Dawley
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4
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9
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2
1
1
4
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641392
Fisher
Regulation of pantothenate kin ...
Rattus norvegicus, Rattus norvegicus Sprague-Dawley
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1
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4412
Nishimura
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Mechanism of coenzyme A biosyn ...
Micrococcus luteus
J. Ferment. Technol.
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1983
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641390
Halvorsen
Regulation of the biosynthesis ...
Rattus norvegicus
Eur. J. Biochem.
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1
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641389
Shimizu
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Purification and properties of ...
Corynebacterium ammoniagenes
Agric. Biol. Chem.
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2863-2870
1973
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19
3
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1
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19
4
3
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1
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1
1
7
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3
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641387
Abiko
Purification and properties of ...
Rattus norvegicus
Biochim. Biophys. Acta
268
364-372
1972
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6
2
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1
2
2
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6
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1
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2
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4406
Brown
The metabolism of pantothenic ...
Escherichia coli, Lactobacillus plantarum, Morganella morganii, no activity in Lactobacillus helveticus, no activity in Neurospora crassa, Rattus norvegicus, Saccharomyces cerevisiae
J. Biol. Chem.
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1959
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