Cloned (Comment) | Organism |
---|---|
- |
Homo sapiens |
Crystallization (Comment) | Organism |
---|---|
using 0.1 M sodium formate, 8-12% (w/v) PEG 3350 at 18°C | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(4-methyl-1,4-diazepan-1-yl)(4'-((4-methyl-1,4-diazepan-1-yl)-methyl)-[1,1'-biphenyl]-4-yl)methanone | - |
Homo sapiens | |
1-((4'-methoxy-[1,1'-biphenyl]-4-yl)methyl)-4-methyl-1,4-diazepane | - |
Homo sapiens | |
1-([1,1'-biphenyl]-4-ylmethyl)-4-methyl-1,4-diazepane | - |
Homo sapiens | |
1-methyl-4-((4'-(4-methylpiperazin-1-yl)-[1,1'-biphenyl]-4-yl)-methyl)-1,4-diazepane | - |
Homo sapiens | |
1-methyl-4-((4'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)methyl)-1,4-diazepane | - |
Homo sapiens | |
1-methyl-4-(naphthalen-2-ylmethyl)-1,4-diazepane | - |
Homo sapiens | |
2'-fluoro-4,4'-bis((4-methyl-1,4-diazepan-1-yl)methyl)-[1,1'-biphenyl]-2-carbonitrile | - |
Homo sapiens | |
4,4'-((2,3-difluoro-[1,1'-biphenyl]-4,4'-diyl)bis(methylene))bis-(1-methyl-1,4-diazepane) | - |
Homo sapiens | |
4,4'-((2-fluoro-[1,1'-biphenyl]-4,4'-diyl)bis(methylene))bis(1-methyl-1,4-diazepane) | - |
Homo sapiens | |
4,4'-((3,5-difluoro-[1,1'-biphenyl]-4,4'-diyl)bis(methylene))bis-(1-methyl-1,4-diazepane) | - |
Homo sapiens | |
4,4'-((3-chloro-[1,1'-biphenyl]-4,4'-diyl)bis(methylene))bis(1-methyl-1,4-diazepane) | - |
Homo sapiens | |
4,4'-bis((4-methyl-1,4-diazepan-1-yl)methyl)-1,1'-biphenyl | - |
Homo sapiens | |
4,4'-bis((4-methyl-1,4-diazepan-1-yl)methyl)-[1,1'-biphenyl]-2-carbonitrile | - |
Homo sapiens | |
7-((4-methyl-1,4-diazepan-1-yl)methyl)quinolone | - |
Homo sapiens | |
hemicholinium-3 | - |
Homo sapiens | |
methyl 4'-((4-methyl-1,4-diazepan-1-yl)methyl)-[1,1'-biphenyl]-4-carboxylate | - |
Homo sapiens | |
RSM-932A | - |
Homo sapiens | |
V-11-0711 | - |
Homo sapiens | |
VX-11-023907 | - |
Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
94000 | - |
2 * 94000, SDS-PAGE | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + choline | Homo sapiens | - |
ADP + phosphocholine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P35790 | - |
- |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
MCF-10A cell | - |
Homo sapiens | - |
MCF-12A cell | - |
Homo sapiens | - |
MDA-MB-415 cell | - |
Homo sapiens | - |
MDA-MB-468 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + choline | - |
Homo sapiens | ADP + phosphocholine | - |
? |
Subunits | Comment | Organism |
---|---|---|
homodimer | 2 * 94000, SDS-PAGE | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
ChoKalpha | - |
Homo sapiens |
choline kinase alpha | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000066 | - |
at pH 7.0, temperature not specified in the publication | Homo sapiens | 4,4'-bis((4-methyl-1,4-diazepan-1-yl)methyl)-[1,1'-biphenyl]-2-carbonitrile | |
0.000085 | - |
at pH 7.0, temperature not specified in the publication | Homo sapiens | 2'-fluoro-4,4'-bis((4-methyl-1,4-diazepan-1-yl)methyl)-[1,1'-biphenyl]-2-carbonitrile | |
0.000165 | - |
at pH 7.0, temperature not specified in the publication | Homo sapiens | 4,4'-((2-fluoro-[1,1'-biphenyl]-4,4'-diyl)bis(methylene))bis(1-methyl-1,4-diazepane) | |
0.000233 | - |
at pH 7.0, temperature not specified in the publication | Homo sapiens | 4,4'-((2,3-difluoro-[1,1'-biphenyl]-4,4'-diyl)bis(methylene))bis-(1-methyl-1,4-diazepane) | |
0.000251 | - |
at pH 7.0, temperature not specified in the publication | Homo sapiens | (4-methyl-1,4-diazepan-1-yl)(4'-((4-methyl-1,4-diazepan-1-yl)-methyl)-[1,1'-biphenyl]-4-yl)methanone | |
0.000255 | - |
at pH 7.0, temperature not specified in the publication | Homo sapiens | 4,4'-((3,5-difluoro-[1,1'-biphenyl]-4,4'-diyl)bis(methylene))bis-(1-methyl-1,4-diazepane) | |
0.000268 | - |
at pH 7.0, temperature not specified in the publication | Homo sapiens | 4,4'-((3-chloro-[1,1'-biphenyl]-4,4'-diyl)bis(methylene))bis(1-methyl-1,4-diazepane) | |
0.000457 | - |
at pH 7.0, temperature not specified in the publication | Homo sapiens | 4,4'-bis((4-methyl-1,4-diazepan-1-yl)methyl)-1,1'-biphenyl | |
0.0013 | - |
at pH 7.0, temperature not specified in the publication | Homo sapiens | 1-methyl-4-((4'-(4-methylpiperazin-1-yl)-[1,1'-biphenyl]-4-yl)-methyl)-1,4-diazepane | |
0.00143 | - |
at pH 7.0, temperature not specified in the publication | Homo sapiens | 1-((4'-methoxy-[1,1'-biphenyl]-4-yl)methyl)-4-methyl-1,4-diazepane | |
0.0015 | - |
at pH 7.0, temperature not specified in the publication | Homo sapiens | 7-((4-methyl-1,4-diazepan-1-yl)methyl)quinolone | |
0.0015 | - |
at pH 7.0, temperature not specified in the publication | Homo sapiens | 1-([1,1'-biphenyl]-4-ylmethyl)-4-methyl-1,4-diazepane | |
0.0026 | - |
at pH 7.0, temperature not specified in the publication | Homo sapiens | 1-methyl-4-(naphthalen-2-ylmethyl)-1,4-diazepane | |
0.0026 | - |
at pH 7.0, temperature not specified in the publication | Homo sapiens | 1-methyl-4-((4'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)methyl)-1,4-diazepane | |
0.00495 | - |
at pH 7.0, temperature not specified in the publication | Homo sapiens | methyl 4'-((4-methyl-1,4-diazepan-1-yl)methyl)-[1,1'-biphenyl]-4-carboxylate |