BRENDA - Enzyme Database show
show all sequences of 2.7.1.32

Novel small molecule inhibitors of choline kinase identified by fragment-based drug discovery

Zech, S.G.; Kohlmann, A.; Zhou, T.; Li, F.; Squillace, R.M.; Parillon, L.E.; Greenfield, M.T.; Miller, D.P.; Qi, J.; Thomas, R.M.; Wang, Y.; Xu, Y.; Miret, J.J.; Shakespeare, W.C.; Zhu, X.; Dalgarno, D.C.; J. Med. Chem. 59, 671-686 (2016)

Data extracted from this reference:

Cloned(Commentary)
Commentary
Organism
-
Homo sapiens
Crystallization (Commentary)
Crystallization
Organism
using 0.1 M sodium formate, 8-12% (w/v) PEG 3350 at 18°C
Homo sapiens
Inhibitors
Inhibitors
Commentary
Organism
Structure
(4-methyl-1,4-diazepan-1-yl)(4'-((4-methyl-1,4-diazepan-1-yl)-methyl)-[1,1'-biphenyl]-4-yl)methanone
-
Homo sapiens
1-((4'-methoxy-[1,1'-biphenyl]-4-yl)methyl)-4-methyl-1,4-diazepane
-
Homo sapiens
1-([1,1'-biphenyl]-4-ylmethyl)-4-methyl-1,4-diazepane
-
Homo sapiens
1-methyl-4-((4'-(4-methylpiperazin-1-yl)-[1,1'-biphenyl]-4-yl)-methyl)-1,4-diazepane
-
Homo sapiens
1-methyl-4-((4'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)methyl)-1,4-diazepane
-
Homo sapiens
1-methyl-4-(naphthalen-2-ylmethyl)-1,4-diazepane
-
Homo sapiens
2'-fluoro-4,4'-bis((4-methyl-1,4-diazepan-1-yl)methyl)-[1,1'-biphenyl]-2-carbonitrile
-
Homo sapiens
4,4'-((2,3-difluoro-[1,1'-biphenyl]-4,4'-diyl)bis(methylene))bis-(1-methyl-1,4-diazepane)
-
Homo sapiens
4,4'-((2-fluoro-[1,1'-biphenyl]-4,4'-diyl)bis(methylene))bis(1-methyl-1,4-diazepane)
-
Homo sapiens
4,4'-((3,5-difluoro-[1,1'-biphenyl]-4,4'-diyl)bis(methylene))bis-(1-methyl-1,4-diazepane)
-
Homo sapiens
4,4'-((3-chloro-[1,1'-biphenyl]-4,4'-diyl)bis(methylene))bis(1-methyl-1,4-diazepane)
-
Homo sapiens
4,4'-bis((4-methyl-1,4-diazepan-1-yl)methyl)-1,1'-biphenyl
-
Homo sapiens
4,4'-bis((4-methyl-1,4-diazepan-1-yl)methyl)-[1,1'-biphenyl]-2-carbonitrile
-
Homo sapiens
7-((4-methyl-1,4-diazepan-1-yl)methyl)quinolone
-
Homo sapiens
hemicholinium-3
-
Homo sapiens
methyl 4'-((4-methyl-1,4-diazepan-1-yl)methyl)-[1,1'-biphenyl]-4-carboxylate
-
Homo sapiens
RSM-932A
-
Homo sapiens
V-11-0711
-
Homo sapiens
VX-11-023907
-
Homo sapiens
Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
94000
-
2 * 94000, SDS-PAGE
Homo sapiens
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ATP + choline
Homo sapiens
-
ADP + phosphocholine
-
-
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Homo sapiens
P35790
-
-
Purification (Commentary)
Commentary
Organism
-
Homo sapiens
Source Tissue
Source Tissue
Commentary
Organism
Textmining
MCF-10A cell
-
Homo sapiens
-
MCF-12A cell
-
Homo sapiens
-
MDA-MB-415 cell
-
Homo sapiens
-
MDA-MB-468 cell
-
Homo sapiens
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ATP + choline
-
738851
Homo sapiens
ADP + phosphocholine
-
-
-
?
Subunits
Subunits
Commentary
Organism
homodimer
2 * 94000, SDS-PAGE
Homo sapiens
IC50 Value
IC50 Value
IC50 Value Maximum
Commentary
Organism
Inhibitor
Structure
0.000066
-
at pH 7.0, temperature not specified in the publication
Homo sapiens
4,4'-bis((4-methyl-1,4-diazepan-1-yl)methyl)-[1,1'-biphenyl]-2-carbonitrile
0.000085
-
at pH 7.0, temperature not specified in the publication
Homo sapiens
2'-fluoro-4,4'-bis((4-methyl-1,4-diazepan-1-yl)methyl)-[1,1'-biphenyl]-2-carbonitrile
0.000165
-
at pH 7.0, temperature not specified in the publication
Homo sapiens
4,4'-((2-fluoro-[1,1'-biphenyl]-4,4'-diyl)bis(methylene))bis(1-methyl-1,4-diazepane)
0.000233
-
at pH 7.0, temperature not specified in the publication
Homo sapiens
4,4'-((2,3-difluoro-[1,1'-biphenyl]-4,4'-diyl)bis(methylene))bis-(1-methyl-1,4-diazepane)
0.000251
-
at pH 7.0, temperature not specified in the publication
Homo sapiens
(4-methyl-1,4-diazepan-1-yl)(4'-((4-methyl-1,4-diazepan-1-yl)-methyl)-[1,1'-biphenyl]-4-yl)methanone
0.000255
-
at pH 7.0, temperature not specified in the publication
Homo sapiens
4,4'-((3,5-difluoro-[1,1'-biphenyl]-4,4'-diyl)bis(methylene))bis-(1-methyl-1,4-diazepane)
0.000268
-
at pH 7.0, temperature not specified in the publication
Homo sapiens
4,4'-((3-chloro-[1,1'-biphenyl]-4,4'-diyl)bis(methylene))bis(1-methyl-1,4-diazepane)
0.000457
-
at pH 7.0, temperature not specified in the publication
Homo sapiens
4,4'-bis((4-methyl-1,4-diazepan-1-yl)methyl)-1,1'-biphenyl
0.0013
-
at pH 7.0, temperature not specified in the publication
Homo sapiens
1-methyl-4-((4'-(4-methylpiperazin-1-yl)-[1,1'-biphenyl]-4-yl)-methyl)-1,4-diazepane
0.00143
-
at pH 7.0, temperature not specified in the publication
Homo sapiens
1-((4'-methoxy-[1,1'-biphenyl]-4-yl)methyl)-4-methyl-1,4-diazepane
0.0015
-
at pH 7.0, temperature not specified in the publication
Homo sapiens
1-([1,1'-biphenyl]-4-ylmethyl)-4-methyl-1,4-diazepane
0.0015
-
at pH 7.0, temperature not specified in the publication
Homo sapiens
7-((4-methyl-1,4-diazepan-1-yl)methyl)quinolone
0.0026
-
at pH 7.0, temperature not specified in the publication
Homo sapiens
1-methyl-4-((4'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)methyl)-1,4-diazepane
0.0026
-
at pH 7.0, temperature not specified in the publication
Homo sapiens
1-methyl-4-(naphthalen-2-ylmethyl)-1,4-diazepane
0.00495
-
at pH 7.0, temperature not specified in the publication
Homo sapiens
methyl 4'-((4-methyl-1,4-diazepan-1-yl)methyl)-[1,1'-biphenyl]-4-carboxylate
Cloned(Commentary) (protein specific)
Commentary
Organism
-
Homo sapiens
Crystallization (Commentary) (protein specific)
Crystallization
Organism
using 0.1 M sodium formate, 8-12% (w/v) PEG 3350 at 18°C
Homo sapiens
IC50 Value (protein specific)
IC50 Value
IC50 Value Maximum
Commentary
Organism
Inhibitor
Structure
0.000066
-
at pH 7.0, temperature not specified in the publication
Homo sapiens
4,4'-bis((4-methyl-1,4-diazepan-1-yl)methyl)-[1,1'-biphenyl]-2-carbonitrile
0.000085
-
at pH 7.0, temperature not specified in the publication
Homo sapiens
2'-fluoro-4,4'-bis((4-methyl-1,4-diazepan-1-yl)methyl)-[1,1'-biphenyl]-2-carbonitrile
0.000165
-
at pH 7.0, temperature not specified in the publication
Homo sapiens
4,4'-((2-fluoro-[1,1'-biphenyl]-4,4'-diyl)bis(methylene))bis(1-methyl-1,4-diazepane)
0.000233
-
at pH 7.0, temperature not specified in the publication
Homo sapiens
4,4'-((2,3-difluoro-[1,1'-biphenyl]-4,4'-diyl)bis(methylene))bis-(1-methyl-1,4-diazepane)
0.000251
-
at pH 7.0, temperature not specified in the publication
Homo sapiens
(4-methyl-1,4-diazepan-1-yl)(4'-((4-methyl-1,4-diazepan-1-yl)-methyl)-[1,1'-biphenyl]-4-yl)methanone
0.000255
-
at pH 7.0, temperature not specified in the publication
Homo sapiens
4,4'-((3,5-difluoro-[1,1'-biphenyl]-4,4'-diyl)bis(methylene))bis-(1-methyl-1,4-diazepane)
0.000268
-
at pH 7.0, temperature not specified in the publication
Homo sapiens
4,4'-((3-chloro-[1,1'-biphenyl]-4,4'-diyl)bis(methylene))bis(1-methyl-1,4-diazepane)
0.000457
-
at pH 7.0, temperature not specified in the publication
Homo sapiens
4,4'-bis((4-methyl-1,4-diazepan-1-yl)methyl)-1,1'-biphenyl
0.0013
-
at pH 7.0, temperature not specified in the publication
Homo sapiens
1-methyl-4-((4'-(4-methylpiperazin-1-yl)-[1,1'-biphenyl]-4-yl)-methyl)-1,4-diazepane
0.00143
-
at pH 7.0, temperature not specified in the publication
Homo sapiens
1-((4'-methoxy-[1,1'-biphenyl]-4-yl)methyl)-4-methyl-1,4-diazepane
0.0015
-
at pH 7.0, temperature not specified in the publication
Homo sapiens
1-([1,1'-biphenyl]-4-ylmethyl)-4-methyl-1,4-diazepane
0.0015
-
at pH 7.0, temperature not specified in the publication
Homo sapiens
7-((4-methyl-1,4-diazepan-1-yl)methyl)quinolone
0.0026
-
at pH 7.0, temperature not specified in the publication
Homo sapiens
1-methyl-4-((4'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)methyl)-1,4-diazepane
0.0026
-
at pH 7.0, temperature not specified in the publication
Homo sapiens
1-methyl-4-(naphthalen-2-ylmethyl)-1,4-diazepane
0.00495
-
at pH 7.0, temperature not specified in the publication
Homo sapiens
methyl 4'-((4-methyl-1,4-diazepan-1-yl)methyl)-[1,1'-biphenyl]-4-carboxylate
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
(4-methyl-1,4-diazepan-1-yl)(4'-((4-methyl-1,4-diazepan-1-yl)-methyl)-[1,1'-biphenyl]-4-yl)methanone
-
Homo sapiens
1-((4'-methoxy-[1,1'-biphenyl]-4-yl)methyl)-4-methyl-1,4-diazepane
-
Homo sapiens
1-([1,1'-biphenyl]-4-ylmethyl)-4-methyl-1,4-diazepane
-
Homo sapiens
1-methyl-4-((4'-(4-methylpiperazin-1-yl)-[1,1'-biphenyl]-4-yl)-methyl)-1,4-diazepane
-
Homo sapiens
1-methyl-4-((4'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)methyl)-1,4-diazepane
-
Homo sapiens
1-methyl-4-(naphthalen-2-ylmethyl)-1,4-diazepane
-
Homo sapiens
2'-fluoro-4,4'-bis((4-methyl-1,4-diazepan-1-yl)methyl)-[1,1'-biphenyl]-2-carbonitrile
-
Homo sapiens
4,4'-((2,3-difluoro-[1,1'-biphenyl]-4,4'-diyl)bis(methylene))bis-(1-methyl-1,4-diazepane)
-
Homo sapiens
4,4'-((2-fluoro-[1,1'-biphenyl]-4,4'-diyl)bis(methylene))bis(1-methyl-1,4-diazepane)
-
Homo sapiens
4,4'-((3,5-difluoro-[1,1'-biphenyl]-4,4'-diyl)bis(methylene))bis-(1-methyl-1,4-diazepane)
-
Homo sapiens
4,4'-((3-chloro-[1,1'-biphenyl]-4,4'-diyl)bis(methylene))bis(1-methyl-1,4-diazepane)
-
Homo sapiens
4,4'-bis((4-methyl-1,4-diazepan-1-yl)methyl)-1,1'-biphenyl
-
Homo sapiens
4,4'-bis((4-methyl-1,4-diazepan-1-yl)methyl)-[1,1'-biphenyl]-2-carbonitrile
-
Homo sapiens
7-((4-methyl-1,4-diazepan-1-yl)methyl)quinolone
-
Homo sapiens
hemicholinium-3
-
Homo sapiens
methyl 4'-((4-methyl-1,4-diazepan-1-yl)methyl)-[1,1'-biphenyl]-4-carboxylate
-
Homo sapiens
RSM-932A
-
Homo sapiens
V-11-0711
-
Homo sapiens
VX-11-023907
-
Homo sapiens
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
94000
-
2 * 94000, SDS-PAGE
Homo sapiens
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ATP + choline
Homo sapiens
-
ADP + phosphocholine
-
-
?
Purification (Commentary) (protein specific)
Commentary
Organism
-
Homo sapiens
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
MCF-10A cell
-
Homo sapiens
-
MCF-12A cell
-
Homo sapiens
-
MDA-MB-415 cell
-
Homo sapiens
-
MDA-MB-468 cell
-
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ATP + choline
-
738851
Homo sapiens
ADP + phosphocholine
-
-
-
?
Subunits (protein specific)
Subunits
Commentary
Organism
homodimer
2 * 94000, SDS-PAGE
Homo sapiens
Other publictions for EC 2.7.1.32
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
738851
Zech
Novel small molecule inhibitor ...
Homo sapiens
J. Med. Chem.
59
671-686
2016
-
-
1
1
-
-
19
-
-
-
1
1
-
3
-
-
1
-
-
4
-
-
1
1
-
-
-
-
-
-
-
-
-
-
15
-
-
1
-
1
-
-
15
19
-
-
-
-
1
1
-
-
-
1
-
4
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
739447
Chang
Phosphorylation of human choli ...
Homo sapiens
PLoS ONE
11
e0154702
2016
-
-
-
-
1
-
1
4
-
-
1
1
-
3
-
1
-
-
-
-
-
-
1
1
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
4
-
-
1
1
-
-
1
-
-
-
-
-
1
1
-
-
-
4
-
-
-
-
-
1
1
-
4
4
739680
Schiaffino-Ortega
Design, synthesis, crystalliza ...
Homo sapiens
Sci. Rep.
6
23793
2016
-
-
1
1
-
-
19
-
-
1
-
1
-
2
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
14
-
-
1
-
1
-
-
14
19
-
-
-
1
-
1
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
739407
Wang
Structural and enzymatic chara ...
Streptococcus pneumoniae
PLoS ONE
10
e0120467
2015
-
-
1
1
3
-
1
1
1
1
-
1
-
3
-
-
1
-
-
-
-
-
1
-
-
-
-
1
1
-
-
-
-
-
-
-
-
1
-
1
3
-
-
1
-
1
1
1
-
1
-
-
-
1
-
-
-
-
1
-
-
-
-
1
1
-
-
-
-
-
-
-
1
1
737751
Li
Phosphatidylcholine metabolism ...
Homo sapiens
Biochim. Biophys. Acta
1841
859-867
2014
-
-
-
-
-
-
-
-
-
-
-
1
-
2
-
-
-
-
-
4
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
4
-
-
1
-
-
-
-
-
-
-
-
-
1
2
2
1
-
-
738832
Rubio-Ruiz
Discovery of a new binding sit ...
Homo sapiens
J. Med. Chem.
57
507-515
2014
-
-
-
1
-
-
13
-
-
-
-
1
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
12
-
-
-
-
1
-
-
12
13
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
721292
Sahun-Roncero
The mechanism of allosteric co ...
Helicobacter pylori
Angew. Chem. Int. Ed. Engl.
52
4582-4586
2013
-
-
-
-
-
-
2
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
721743
Hudson
Kinetic and mechanistic charac ...
Homo sapiens
Biochim. Biophys. Acta
1834
1107-1116
2013
-
-
1
1
-
-
1
2
1
-
-
-
-
2
-
-
1
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
1
-
-
1
-
1
-
-
1
1
-
2
1
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
737834
Schiaffino-Ortega
New non-symmetrical choline ki ...
Homo sapiens
Bioorg. Med. Chem.
21
7146-7154
2013
-
-
-
-
-
-
16
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
16
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
738968
Trousil
Design of symmetrical and nons ...
Homo sapiens
MedChemComm
2013
693-696
2013
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
739185
Mori
Characterization of choline ki ...
Homo sapiens
NMR Biomed.
26
1501-1507
2013
-
1
-
-
-
-
-
-
-
-
-
1
-
4
-
-
-
-
-
3
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
3
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
722191
Rubio-Ruiz
Design, synthesis, theoretical ...
Homo sapiens
Eur. J. Med. Chem.
50
154-162
2012
-
-
-
-
-
-
14
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
3
14
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
722242
Gruber
Balance of human choline kinas ...
Homo sapiens
FEBS J.
279
1915-1928
2012
-
-
-
-
-
-
-
-
3
-
-
-
-
2
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
2
2
-
-
-
722754
Sampels
Conditional mutagenesis of a n ...
Toxoplasma gondii
J. Biol. Chem.
287
16289-16299
2012
-
-
1
-
-
-
1
2
1
-
3
-
-
2
-
-
1
-
-
1
-
-
3
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
2
1
-
3
-
-
-
-
1
-
1
-
-
3
1
-
-
-
-
-
-
-
-
-
1
1
-
-
-
722904
Bansal
Choline phosphorylation and re ...
Homo sapiens
J. Lipid Res.
53
149-157
2012
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
723311
Miyake
Functional interactions betwee ...
Homo sapiens
Oncogene
31
1431-1441
2012
2
-
-
-
4
-
-
-
-
-
-
-
-
1
-
-
-
-
-
5
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
5
-
-
1
-
-
-
-
-
-
-
-
-
-
2
2
-
-
-
702145
Alberge
Comparison of the cellular and ...
Plasmodium falciparum 3D7
Biochem. J.
425
149-158
2010
-
-
1
-
-
-
3
2
-
-
1
-
-
3
-
-
1
-
-
-
2
-
1
1
-
-
-
-
-
-
-
-
2
-
5
-
-
1
-
-
-
-
5
3
2
2
-
-
1
-
-
-
-
1
-
-
2
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
721704
Wu
Differential expression of cho ...
Mus musculus
Biochim. Biophys. Acta
1801
446-454
2010
-
-
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
3
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
1
-
-
-
-
-
-
-
-
-
1
1
1
1
-
-
722672
Hong
Crystal structures of human ch ...
Homo sapiens
J. Biol. Chem.
285
16330-16340
2010
-
1
1
1
4
-
1
12
-
1
-
-
-
3
-
-
1
-
-
-
-
-
2
-
-
-
-
7
-
-
-
-
7
-
-
-
2
2
-
2
4
-
-
2
7
13
-
2
-
-
-
-
-
2
-
-
-
-
2
-
-
-
-
7
-
-
-
-
-
-
-
-
-
-
705211
Srivani
Potential choline kinase inhib ...
Homo sapiens
J. Mol. Graph. Model.
27
676-688
2009
-
-
-
-
-
-
49
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
39
-
-
-
-
-
-
-
39
49
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
705538
Elswaifi
Molecular characterization of ...
Histophilus somni
Microb. Pathog.
47
223-230
2009
-
-
1
-
-
-
-
-
-
-
-
-
-
5
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
705667
Chua
Regulation of Akt(ser473)phosp ...
Homo sapiens
Mol. Cancer
8
131
2009
-
-
-
-
-
-
2
-
-
-
-
-
-
3
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
705894
Nimmagadda
Pharmacodynamic markers for ch ...
Homo sapiens
Neoplasia
11
477-484
2009
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
706015
Yalcin
Selective inhibition of cholin ...
Homo sapiens
Oncogene
29
139-149
2009
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
706447
Gallego-Ortega
Differential role of human cho ...
Homo sapiens
PLoS ONE
4
e7819
2009
-
-
1
-
-
-
1
4
-
-
3
-
-
3
-
-
-
-
-
-
-
-
4
1
-
-
-
-
-
-
-
-
-
-
2
-
-
2
-
-
-
-
2
2
-
4
-
-
3
-
-
-
-
-
-
-
-
-
4
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
685011
Gibellini
Biochemical characterization o ...
Trypanosoma brucei
Biochem. J.
415
135-144
2008
1
-
1
-
-
-
-
3
-
-
1
2
-
2
-
-
1
-
-
1
1
-
8
1
-
-
-
1
1
-
-
1
-
-
-
1
-
1
1
-
-
-
-
-
-
3
-
-
1
2
-
-
-
1
-
1
1
-
8
1
-
-
-
1
1
-
-
-
-
-
-
-
-
-
685954
Glunde
Hypoxia regulates choline kina ...
Homo sapiens
Cancer Res.
68
172-180
2008
-
1
1
-
-
-
-
-
1
-
-
-
-
3
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
687121
Ramirez de Molina
Choline kinase as a link conne ...
Homo sapiens
Int. J. Biochem. Cell Biol.
40
1753-1763
2008
-
2
1
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
1
1
-
-
-
1
-
-
-
1
-
-
1
-
-
-
-
2
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
687686
Soto
Regulation of the Saccharomyce ...
Saccharomyces cerevisiae
J. Biol. Chem.
283
10079-10088
2008
1
-
1
-
-
-
-
-
-
-
-
1
-
2
-
-
-
-
-
1
1
-
1
-
-
-
-
-
1
-
-
1
-
-
-
1
-
1
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
687709
Aoyama
Early embryonic lethality caus ...
Mus musculus
J. Biol. Chem.
283
1456-1462
2008
-
-
1
-
-
-
1
-
1
-
-
1
-
3
-
-
-
-
-
3
1
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
1
-
-
1
-
-
-
-
-
3
1
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
705659
Ross
Fatty acid synthase inhibition ...
Homo sapiens
Mol. Cancer Ther.
7
2556-2565
2008
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
671362
Al-Saeedi
[Methyl-3H]-choline incorporat ...
Homo sapiens
Anticancer Res.
27
901-906
2007
1
-
-
-
-
-
-
-
1
1
-
1
-
2
-
-
-
-
-
2
2
-
2
-
1
-
-
-
1
-
-
1
-
-
-
1
-
-
1
-
-
-
-
-
-
-
1
1
-
1
-
-
-
-
-
2
2
-
2
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
671383
Choubey
Inhibition of Plasmodium falci ...
Plasmodium falciparum
Antimicrob. Agents Chemother.
51
696-706
2007
-
-
1
-
-
-
4
-
-
1
-
1
-
4
-
-
1
-
-
2
-
-
2
-
1
-
-
-
1
-
-
1
-
-
-
-
-
1
1
-
-
-
-
4
-
-
-
1
-
1
-
-
-
1
-
2
-
-
2
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
685337
Aoyama
Induction of choline kinase al ...
Mus musculus
Biochim. Biophys. Acta
1771
1148-1155
2007
1
-
1
-
-
-
-
-
1
-
-
1
-
4
-
-
-
-
-
3
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
2
-
2
1
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
4
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
685941
Mori
Choline kinase down-regulation ...
Homo sapiens
Cancer Res.
67
11284-11290
2007
-
1
1
-
-
-
1
-
-
-
-
1
-
1
-
-
-
-
-
3
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
3
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
688743
Ramirez de Molina
Expression of choline kinase a ...
Homo sapiens
Lancet Oncol.
8
889-897
2007
1
1
-
-
-
-
1
-
-
-
-
1
-
2
-
-
-
-
-
8
1
-
1
-
-
-
-
-
1
-
-
1
-
-
17
1
1
-
1
-
-
-
17
1
-
-
-
-
-
1
-
-
-
-
-
8
1
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
672361
Choubey
Molecular characterization and ...
Plasmodium falciparum
Biochim. Biophys. Acta
1760
1027-1038
2006
-
-
1
-
-
-
2
3
1
-
2
-
-
3
-
-
1
-
-
-
-
-
2
-
-
-
-
-
1
-
-
1
2
-
-
-
-
1
1
-
-
-
-
2
2
3
1
-
2
-
-
-
-
1
-
-
-
-
2
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
672371
Liao
Deletion and alanine mutation ...
Mus musculus
Biochim. Biophys. Acta
1761
111-120
2006
-
-
1
-
-
-
-
4
-
1
-
-
-
2
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
4
-
1
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
673093
Milanese
Insight into the inhibition of ...
Caenorhabditis elegans, Homo sapiens
ChemMedChem
1
1216-1228
2006
-
-
-
-
25
-
4
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
2
-
25
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
673201
Janardhan
Choline kinase: an important t ...
Caenorhabditis elegans, Homo sapiens, Mus musculus, Rattus norvegicus, Saccharomyces cerevisiae, Schizosaccharomyces pombe
Curr. Med. Chem.
13
1169-1186
2006
-
1
-
3
9
-
11
-
6
12
8
-
-
9
-
-
-
-
-
13
-
-
6
5
-
-
-
-
1
-
-
6
-
-
1
-
1
-
6
3
9
-
1
11
-
-
6
12
8
-
-
-
-
-
-
13
-
-
6
5
-
-
-
-
1
-
-
-
-
-
-
-
-
-
673202
Campos
(Q)SAR studies to design new h ...
Homo sapiens
Curr. Med. Chem.
13
1231-1248
2006
-
-
-
-
-
-
71
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
71
-
-
-
1
-
-
-
71
71
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
675410
Malito
Elucidation of human choline k ...
Homo sapiens
J. Mol. Biol.
364
136-151
2006
-
-
1
1
-
-
1
1
-
-
1
-
-
3
-
-
1
-
-
1
-
-
1
1
-
-
-
1
-
-
-
1
-
-
-
-
-
1
1
1
-
-
-
1
-
1
-
-
1
-
-
-
-
1
-
1
-
-
1
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
672898
Glunde
RNA interference-mediated chol ...
Homo sapiens
Cancer Res.
65
11034-11043
2005
-
-
-
-
-
-
-
-
-
-
1
-
-
2
-
-
-
-
-
6
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
6
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
673447
Conejo-Garcia
Towards a model for the inhibi ...
Homo sapiens
Eur. J. Med. Chem.
40
315-319
2005
-
-
-
-
-
-
5
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
4
-
-
-
1
-
-
-
4
5
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
674066
Rodriguez-Gonzalez
Inhibition of choline kinase r ...
Homo sapiens
Int. J. Oncol.
26
999-1008
2005
-
-
-
-
-
-
1
-
-
-
-
-
-
2
-
-
-
-
-
10
-
-
1
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
1
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
10
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
674456
Choi
Phosphorylation of the yeast c ...
Saccharomyces cerevisiae, Saccharomyces cerevisiae KS106
J. Biol. Chem.
280
26105-26112
2005
-
-
1
-
2
-
-
-
-
-
-
-
-
3
-
-
1
-
-
-
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
-
2
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
661736
Tasseva
Regulation of phosphatidylchol ...
Arabidopsis thaliana
FEBS Lett.
566
115-120
2004
-
-
-
-
-
-
-
-
1
-
-
1
-
3
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
662203
Yuan
Identification of critical res ...
Caenorhabditis elegans
J. Biol. Chem.
279
17801-17809
2004
-
-
1
-
31
-
1
37
-
1
1
1
-
2
-
-
1
-
-
-
-
-
2
1
-
-
-
26
1
-
-
-
-
-
-
-
-
1
-
-
31
-
-
1
-
37
-
1
1
1
-
-
-
1
-
-
-
-
2
1
-
-
-
26
1
-
-
-
-
-
-
-
-
-
663274
Aoyama
Structure and function of chol ...
Caenorhabditis elegans, Homo sapiens, Mus musculus, Rattus norvegicus, Saccharomyces cerevisiae
Prog. Lipid Res.
43
266-281
2004
-
-
1
-
-
-
-
10
-
5
3
5
-
5
-
-
1
-
-
8
-
-
10
6
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
10
-
5
3
5
-
-
-
1
-
8
-
-
10
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
641375
Gee
Multiple isoforms of choline k ...
Caenorhabditis elegans
Biochim. Biophys. Acta
1648
33-42
2003
-
-
1
-
-
-
-
4
-
2
4
-
-
3
-
-
1
-
-
-
2
-
2
2
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
4
-
2
4
-
-
-
-
1
-
-
2
-
2
2
-
-
-
-
1
-
-
-
-
-
-
-
-
-
641384
Peisach
The crystal structure of choli ...
Caenorhabditis elegans
Structure
11
703-713
2003
-
-
-
1
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
663273
Rodriguez-Gonzalez
Phospholipase D and choline ki ...
Homo sapiens, Mus musculus
Prog. Cell Cycle Res.
5
191-201
2003
-
1
-
-
-
-
14
-
2
2
2
2
-
2
-
-
-
-
-
-
-
-
4
2
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
14
-
-
2
2
2
2
-
-
-
-
-
-
-
-
4
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
641376
Yu
Phosphorylation of Saccharomyc ...
Saccharomyces cerevisiae
J. Biol. Chem.
277
34978-34986
2002
-
-
-
-
3
-
-
-
-
-
-
-
-
2
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
641378
Aoyama
Expression and characterizatio ...
Mus musculus
Biochem. J.
363
777-784
2002
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
641380
Al-Malki
Pea choline kinase: purificati ...
Pisum sativum
Biochem. Soc. Trans.
28
721-723
2000
-
-
-
-
-
-
2
1
-
1
1
-
-
4
-
-
1
-
-
1
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
1
-
1
1
-
-
-
-
1
-
1
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
641383
Aoyama
Structure and characterization ...
Mus musculus
J. Lipid Res.
41
452-464
2000
-
-
1
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
641373
Hernandez-Alcoceba
In vivo antitumor activity of ...
Homo sapiens
Cancer Res.
59
3112-3118
1999
-
1
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
641377
Kim
Expression, purification, and ...
Saccharomyces cerevisiae
J. Biol. Chem.
273
6844-6852
1998
-
-
-
-
-
-
1
2
1
1
2
-
-
2
-
-
1
1
-
-
-
-
2
2
1
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
2
1
1
2
-
-
-
-
1
-
-
-
-
2
2
1
-
-
1
1
-
-
-
-
-
-
-
-
-
641381
Liu
Galactosemic cataractogenesis ...
Rattus norvegicus
Exp. Eye Res.
67
193-202
1998
-
1
-
-
-
-
-
-
-
-
-
-
-
7
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
641382
Menten
-
The determination of the choli ...
Brassica sp., Glycine max, Zea mays
J. Sci. Food Agric.
78
395-398
1998
-
3
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
641374
Yamashita
Choline kinase from yeast ...
Saccharomyces cerevisiae
Biochim. Biophys. Acta
1348
63-69
1997
-
-
1
-
-
-
-
-
1
-
-
1
-
3
-
-
1
1
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
1
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
641379
Ishidate
Choline/ethanolamine kinase fr ...
Homo sapiens, Rattus norvegicus
Biochim. Biophys. Acta
1348
70-78
1997
-
-
2
-
-
-
-
-
-
-
-
4
-
2
-
-
2
-
-
-
-
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
2
-
-
-
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
641385
Cao
Partial purification of two fo ...
Rattus norvegicus
Neurochem. Res.
20
643-649
1995
-
-
-
-
-
-
-
-
-
-
1
-
-
2
-
-
1
-
-
1
-
-
4
1
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
1
-
-
4
1
-
-
-
-
-
-
-
2
-
-
-
-
-
-
641352
Uchida
Molecular cloning, characteriz ...
Rattus norvegicus
J. Biol. Chem.
267
10156-10162
1992
-
-
1
-
-
-
-
4
-
-
-
-
-
4
-
-
1
-
-
1
1
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
1
-
1
1
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
641353
Hosaka
Cloning of a human choline kin ...
Homo sapiens
FEBS Lett.
304
229-232
1992
-
-
1
-
-
-
-
-
-
-
1
-
-
4
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
641370
Porter
Choline/ethanolamine kinase fr ...
Rattus norvegicus
Methods Enzymol.
209
134-146
1992
-
-
-
-
-
-
2
3
1
1
2
-
-
2
-
-
1
-
-
1
1
-
1
1
-
-
-
-
-
-
-
-
2
2
-
-
-
-
-
-
-
-
-
2
2
3
1
1
2
-
-
-
-
1
-
1
1
-
1
1
-
-
-
-
-
-
-
2
-
-
-
-
-
-
641371
Uchida
Choline/ethanolamine kinase fr ...
Rattus norvegicus
Methods Enzymol.
209
147-153
1992
4
-
-
-
-
1
-
8
-
9
2
-
-
2
-
-
1
-
-
2
1
1
12
1
1
-
-
-
1
1
-
-
-
-
-
4
-
-
-
-
-
1
-
-
-
8
-
9
2
-
-
-
-
1
-
2
1
1
12
1
1
-
-
-
1
1
-
-
-
-
-
-
-
-
641372
Ishidate
Choline/ethanolamine kinase fr ...
Rattus norvegicus
Methods Enzymol.
209
121-134
1992
1
-
-
-
-
-
10
1
1
1
2
-
-
2
-
-
1
1
-
1
1
1
4
1
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
10
-
1
1
1
2
-
-
-
-
1
-
1
1
1
4
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
641359
Uchida
Purification and properties of ...
Rattus norvegicus
Biochim. Biophys. Acta
1043
281-288
1990
4
-
-
-
-
1
-
10
-
9
2
-
-
2
-
-
1
-
-
3
1
-
9
1
1
-
-
-
1
1
-
-
-
-
-
4
-
-
-
-
-
1
-
-
-
10
-
9
2
-
-
-
-
1
-
3
1
-
9
1
1
-
-
-
1
1
-
-
-
-
-
-
-
-
641368
Porter
Purification and characterizat ...
Rattus norvegicus
J. Biol. Chem.
265
414-422
1990
-
-
-
-
-
-
1
1
-
-
2
1
-
2
-
-
1
1
-
1
1
-
3
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
2
1
-
-
-
1
-
1
1
-
3
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
641364
Kinney
Phosphatidylcholine synthesis ...
Ricinus communis
Arch. Biochem. Biophys.
260
102-108
1988
-
-
-
-
-
-
2
1
1
2
-
-
-
2
-
-
1
1
-
2
-
-
1
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
1
1
2
-
-
-
-
-
1
-
2
-
-
1
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
641363
Clary
Substrate specificity of choli ...
Saccharomyces cerevisiae
Arch. Biochem. Biophys.
254
214-221
1987
-
-
-
-
-
-
-
1
-
-
-
-
-
2
-
-
-
-
-
-
-
-
5
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
5
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
641345
Ishidate
Complete co-purification of ch ...
Rattus norvegicus
Biochim. Biophys. Acta
836
119-124
1985
-
-
-
-
-
-
1
1
2
1
-
-
-
3
-
-
1
1
-
2
1
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
2
1
-
-
-
-
-
1
-
2
1
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
641360
Ishidate
Complete purification of choli ...
Rattus norvegicus
J. Biol. Chem.
259
14706-14710
1984
-
-
-
-
-
-
-
-
-
-
2
-
-
3
-
-
1
-
-
2
1
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
1
-
2
1
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
641350
Ramabrahmam
Ethanolamine kinase from Culex ...
Culex quinquefasciatus
Arch. Biochem. Biophys.
207
55-62
1981
-
-
-
-
-
-
3
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
641365
Hock
-
Localization of phosphatidylch ...
Phaseolus vulgaris
Plant Sci. Lett.
21
389-396
1981
-
-
-
-
-
-
-
-
1
-
-
1
-
1
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
641367
Kariya
-
Isolation and purification of ...
Cyberlindnera jadinii
J. Ferment. Technol.
58
489-492
1980
-
-
-
1
-
-
-
1
-
-
-
-
-
1
-
-
1
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
1
-
-
1
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
641358
Ramabrahamam
-
Choline kinase of Culex pipien ...
Culex quinquefasciatus
Insect Biochem.
9
315-321
1979
-
-
-
-
-
-
4
2
2
1
-
-
-
1
-
-
-
-
-
3
-
-
1
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
4
-
2
2
1
-
-
-
-
-
-
-
3
-
-
1
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
641369
Ulane
Evidence for the existence of ...
Chlorocebus aethiops
Biochim. Biophys. Acta
531
295-300
1978
-
-
-
-
-
-
3
1
-
-
-
-
-
3
-
-
-
1
-
2
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
1
-
-
-
-
-
-
-
-
-
2
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
641347
Brophy
Choline kinase and ethanolamin ...
Rattus norvegicus
Eur. J. Biochem.
78
491-495
1977
-
-
-
-
-
-
7
1
2
-
-
-
-
2
-
-
-
1
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
7
-
1
2
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
641349
Spanner
Choline kinase and ethanolamin ...
Rattus norvegicus
Biochem. Soc. Trans.
5
164-165
1977
-
-
-
-
-
-
-
1
2
1
-
-
-
2
-
-
-
1
-
3
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
2
1
-
-
-
-
-
-
-
3
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
641356
Hartmann
-
Isolation and characterization ...
Phaseolus vulgaris
Z. Pflanzenphysiol.
83
69-80
1977
3
-
-
-
-
-
2
1
-
-
-
-
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
3
-
-
-
-
-
-
-
2
-
1
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
641346
Upreti
Likely individuality of the en ...
Cavia porcellus, Columba livia, Duttaphrynus melanostictus, Gallus gallus, Hemidactylus sp., Heteropneustes fossilis, Hoplobatrachus tigerinus, Mus musculus, Rattus norvegicus
Arch. Biochem. Biophys.
174
658-665
1976
-
-
-
-
-
-
-
-
2
-
-
-
-
9
-
-
-
9
-
4
-
-
9
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
4
-
-
9
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
641354
Infante
Phospholipid synthesis in mamm ...
Bos taurus
Lipids
11
727-735
1976
-
-
-
-
-
-
-
1
1
-
-
-
-
2
-
-
-
1
-
1
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
641366
Fukuyama
-
Activation of rat liver cholin ...
Rattus norvegicus
FEBS Lett.
71
33-36
1976
1
-
-
-
-
-
-
2
-
2
-
-
-
1
-
-
-
-
-
-
-
-
2
-
1
-
-
-
1
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
2
-
2
-
-
-
-
-
-
-
-
-
-
2
-
1
-
-
-
1
1
-
-
-
-
-
-
-
-
641348
Weinhold
The separation, purification, ...
Rattus norvegicus
Biochemistry
13
5135-5141
1974
-
-
-
-
-
-
-
2
-
-
-
-
-
2
-
-
-
1
-
1
1
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
1
1
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
641357
Haubrich
Partial purification and prope ...
Oryctolagus cuniculus
J. Neurochem.
21
315-328
1973
1
-
-
-
-
-
4
2
-
3
-
-
-
2
-
-
-
-
-
1
-
-
4
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
4
-
2
-
3
-
-
-
-
-
-
-
1
-
-
4
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
641361
Brostrom
Choline kinase from brewers ye ...
Saccharomyces cerevisiae
J. Biol. Chem.
248
2364-2371
1973
-
-
-
-
-
2
5
2
-
-
1
-
-
2
-
-
1
1
-
-
-
1
1
-
1
-
2
-
-
-
1
-
-
-
-
-
-
-
-
-
-
2
-
5
-
2
-
-
1
-
-
-
-
1
-
-
-
1
1
-
1
-
2
-
-
-
1
-
-
-
-
-
-
-
641362
Setty
Choline kinase in Cuscuta refl ...
Cuscuta reflexa
Biochem. J.
126
313-324
1972
-
-
-
-
-
-
7
1
1
1
-
-
-
2
-
-
1
-
-
-
1
1
3
-
1
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
7
-
1
1
1
-
-
-
-
-
1
-
-
1
1
3
-
1
-
-
-
1
1
-
-
-
-
-
-
-
-
641355
Shelley
-
Substrate specificity and inhi ...
Phormia regina
Insect Biochem.
1
149-156
1971
-
-
-
-
-
-
5
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
5
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
5
-
-
-
-
-
-
-
-
-
1
-
-
-
-
5
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
641351
Wittenberg
Choline phosphokinase ...
Saccharomyces cerevisiae
J. Biol. Chem.
202
431-444
1953
1
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
5
-
-
-
-
-
1
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
5
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-