Literature summary for 2.7.1.30 extracted from

Lee, D.H.; Park, D.B.; Lee, Y.K.; An, C.S.; Oh, Y.S.; Kang, J.S.; Kang, S.H.; Chung, M.Y.
The effects of thiazolidinedione treatment on the regulations of aquaglyceroporins and glycerol kinase in OLETF rats (2005), Metab. Clin. Exp., 54, 1282-1289.

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Activating Compound

Activating Compound	Comment	Organism	Structure
rosiglitazone	rosiglitazone treatment markebly increases glycerol kinase mRNA expression in both the mesenteric and epididymal adipose tissues (1085.9% and 523.8% of the abundance in Long-Evans Tokushima Otsuka rats, respectively). The magnitude of glycerol kinase induced by rosiglitazone is significantly greater in the mesenteric fat than in the epididymal fat.	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	Long-Evans Tokushima Otsuka, Otsuka Long-Evans Tokushima Fatty and rosiglitazone-treated Otsuka Long-Evans Tokushima Fatty rats, all male and 4 weeks old.	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
adipose	glycerol kinase mRNA tends to increase by 2.5fold in the mesenteric fat from Otsuka Long-Evans Tokushima Fatty rats compared to Long-Evans Tokushima Otsuka rats. A small increase in glycerol kinase mRNA expression is detected in the epididymal fat from Otsuka Long-Evans Tokushima Fatty rats compared with Long-Evans Tokushima Otsuka rats (124.5%). Rosiglitazone treatment markebly increases glycerol kinase mRNA expression in both the mesenteric and epididymal adipose tissues (1085.9% and 523.8% of the abundance in Long-Evans Tokushima Otsuka rats, respectively). The magnitude of glycerol kinase induced by rosiglitazone is significantly greater in the mesenteric fat than in the epididymal fat.	Rattus norvegicus	-
liver	glycerol kinase expression in hepatic tissues shows no significant difference between the experimental groups	Rattus norvegicus	-

Synonyms

Synonyms	Comment	Organism
GLYK	glycerol kinase	Rattus norvegicus

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Release 2023.1 (January 2023)