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Literature summary for 2.7.1.3 extracted from

  • Gao, W.; Li, N.; Li, Z.; Xu, J.; Su, C.
    Ketohexokinase is involved in fructose utilization and promotes tumor progression in glioma (2018), Biochem. Biophys. Res. Commun., 503, 1298-1306 .
    View publication on PubMed
Search for more literature for 2.7.1.3

Organism

Organism UniProt Comment Textmining
Homo sapiens P50053
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-

Source Tissue

Source Tissue Comment Organism Textmining
brain expressed at significantly higher level in glioma tissues than in non-tumor brain Homo sapiens
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glioma cell expressed at significantly higher level in glioma tissues than in non-tumor brain Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + D-fructose
-
 Homo sapiens ADP + D-fructose 1-phosphate
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 ?

Synonyms

Synonyms Comment Organism
KHK
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction functionally, knockdown of ketohexokinase can significantly inhibit cell proliferation and migration of glioma cells in fructose medium Homo sapiens
metabolism key enzyme involved in fructose catabolism Homo sapiens
metabolism ketohexokinase overexpression is significantly correlated with tumor malignancy and poor survival of glioma patients Homo sapiens