Literature summary for 2.7.1.3 extracted from

Li, X.; Qian, X.; Peng, L.X.; Jiang, Y.; Hawke, D.H.; Zheng, Y.; Xia, Y.; Lee, J.H.; Cote, G.; Wang, H.; Wang, L.; Qian, C.N.; Lu, Z.
A splicing switch from ketohexokinase-C to ketohexokinase-A drives hepatocellular carcinomaformation (2016), Nat. Cell Biol., 18, 561-571.

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Application

Application	Comment	Organism
medicine	compared with normal hepatocytes, hepatocellular carcinoma cells markedly reduce the rate of fructose metabolism and the level of reactive oxygen species, as a result of a c-Myc-dependent and heterogeneous nuclear ribonucleoprotein H1- and H2-mediated switch from expression of the high-activity fructokinase KHK-C to the low-activity KHK-A isoform. KHK-A acts as a protein kinase, phosphorylating and activating phosphoribosyl pyrophosphate synthetase PRPS1. c-Myc, hnRNPH1/2 and KHK-A expression levels and PRPS1 Thr225 phosphorylation levels correlate with each other in hepatocellular carcinoma specimens and are associated with poor prognosis for hepatocellular carcinoma	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
HEP-3B cell	-	Homo sapiens	-
Huh-7 cell	hepatocellular carcinoma cell	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
Khk-A	-	Homo sapiens
Khk-C	-	Homo sapiens

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Release 2023.1 (January 2023)