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Literature summary for 2.7.1.3 extracted from
- Fructokinase A acts as a protein kinase to promote nucleotide synthesis (2016), Cell Cycle, 15, 2689-2690.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | mutually exclusive splicing of adjacent exons 3A and 3C in ketohexokinase precursor RNA results in expression of ketohexokinase isoform KHK-A or KHK-C. KHK-A but not KHK-C interacts with phosphoribosyl diphosphate synthetase PRPS1. KHK-A functions as a protein kinase and directly phosphorylates PRPS1 at T225. This phosphorylation blocks the binding of the allosteric inhibitor ADP to PRPS1, thereby abrogating the feedback inhibition by ADP and leading to elevated de novo nucleic acid synthesis by constitutively activating PRPS1 in hepytocellular carcinoma cells | Homo sapiens |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
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