BRENDA - Enzyme Database
show all sequences of 2.7.1.3

Genes required for fructose metabolism are expressed in Purkinje cells in the cerebellum

Funari, V.A.; Herrera, V.L.; Freeman, D.; Tolan, D.R.; Brain Res. Mol. Brain Res. 142, 115-122 (2005)

Data extracted from this reference:

Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
bone
relatively low expression of ketohexokinase.The expression profile for ketohexokinase in human is derived from from Unigene by adding the number of EST clones obtained from normal tissues
Homo sapiens
-
brain
relatively high expression of ketohexokinase.The expression profile for ketohexokinase in human is derived from from Unigene by adding the number of EST clones obtained from normal tissues
Homo sapiens
-
brain
the expression of ketohexokinase is investigated in coronal sections of the hindbrain containing the cerebellum. There is a lack of general DIG-labeled cells in the molecular layer of the cerebellum, but the Purkinje cell layer, which separates the molecular layer from the granular layer, demonstrated the strongest DIG labeling. DIG-labeled RNA in situ hybridization identifies specific cellular location of ketohexokinase mRNA expression.
Mus musculus
-
breast
relatively low expression of ketohexokinase.The expression profile for ketohexokinase in human is derived from from Unigene by adding the number of EST clones obtained from normal tissues
Homo sapiens
-
heart
relatively low expression of ketohexokinase.The expression profile for ketohexokinase in human is derived from from Unigene by adding the number of EST clones obtained from normal tissues
Homo sapiens
-
kidney
high expression of ketohexokinase.The expression profile for ketohexokinase in human is derived from from Unigene by adding the number of EST clones obtained from normal tissues
Homo sapiens
-
liver
high expression of ketohexokinase.The expression profile for ketohexokinase in human is derived from from Unigene by adding the number of EST clones obtained from normal tissues
Homo sapiens
-
lymphocyte
relatively high expression of ketohexokinase.The expression profile for ketohexokinase in human is derived from from Unigene by adding the number of EST clones obtained from normal tissues
Homo sapiens
-
muscle
relatively low expression of ketohexokinase.The expression profile for ketohexokinase in human is derived from from Unigene by adding the number of EST clones obtained from normal tissues
Homo sapiens
-
pancreas
relatively low expression of ketohexokinase.The expression profile for ketohexokinase in human is derived from from Unigene by adding the number of EST clones obtained from normal tissues
Homo sapiens
-
placenta
relatively low expression of ketohexokinase.The expression profile for ketohexokinase in human is derived from from Unigene by adding the number of EST clones obtained from normal tissues
Homo sapiens
-
stomach
relatively low expression of ketohexokinase.The expression profile for ketohexokinase in human is derived from from Unigene by adding the number of EST clones obtained from normal tissues
Homo sapiens
-
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
bone
relatively low expression of ketohexokinase.The expression profile for ketohexokinase in human is derived from from Unigene by adding the number of EST clones obtained from normal tissues
Homo sapiens
-
brain
relatively high expression of ketohexokinase.The expression profile for ketohexokinase in human is derived from from Unigene by adding the number of EST clones obtained from normal tissues
Homo sapiens
-
brain
the expression of ketohexokinase is investigated in coronal sections of the hindbrain containing the cerebellum. There is a lack of general DIG-labeled cells in the molecular layer of the cerebellum, but the Purkinje cell layer, which separates the molecular layer from the granular layer, demonstrated the strongest DIG labeling. DIG-labeled RNA in situ hybridization identifies specific cellular location of ketohexokinase mRNA expression.
Mus musculus
-
breast
relatively low expression of ketohexokinase.The expression profile for ketohexokinase in human is derived from from Unigene by adding the number of EST clones obtained from normal tissues
Homo sapiens
-
heart
relatively low expression of ketohexokinase.The expression profile for ketohexokinase in human is derived from from Unigene by adding the number of EST clones obtained from normal tissues
Homo sapiens
-
kidney
high expression of ketohexokinase.The expression profile for ketohexokinase in human is derived from from Unigene by adding the number of EST clones obtained from normal tissues
Homo sapiens
-
liver
high expression of ketohexokinase.The expression profile for ketohexokinase in human is derived from from Unigene by adding the number of EST clones obtained from normal tissues
Homo sapiens
-
lymphocyte
relatively high expression of ketohexokinase.The expression profile for ketohexokinase in human is derived from from Unigene by adding the number of EST clones obtained from normal tissues
Homo sapiens
-
muscle
relatively low expression of ketohexokinase.The expression profile for ketohexokinase in human is derived from from Unigene by adding the number of EST clones obtained from normal tissues
Homo sapiens
-
pancreas
relatively low expression of ketohexokinase.The expression profile for ketohexokinase in human is derived from from Unigene by adding the number of EST clones obtained from normal tissues
Homo sapiens
-
placenta
relatively low expression of ketohexokinase.The expression profile for ketohexokinase in human is derived from from Unigene by adding the number of EST clones obtained from normal tissues
Homo sapiens
-
stomach
relatively low expression of ketohexokinase.The expression profile for ketohexokinase in human is derived from from Unigene by adding the number of EST clones obtained from normal tissues
Homo sapiens
-
Other publictions for EC 2.7.1.3
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
737995
Li
Fructokinase A acts as a prote ...
Homo sapiens
Cell Cycle
15
2689-2690
2016
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1
1
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739133
Li
A splicing switch from ketohex ...
Homo sapiens
Nat. Cell Biol.
18
561-571
2016
-
1
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739450
Le
Bioactivity-guided identificat ...
Homo sapiens
PLoS ONE
11
e0157458
2016
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6
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7
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1
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737891
Kavitha
Pharmacophore modeling, virtua ...
Homo sapiens
BioSystems
138
39-52
2015
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1
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1
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721134
Maryanoff
Inhibitors of ketohexokinase: ...
Homo sapiens
ACS Med. Chem. Lett.
2
538-543
2011
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48
-
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2
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1
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48
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48
48
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1
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723348
Diggle
Both isoforms of ketohexokinas ...
Mus musculus
Physiol. Genomics
42 A
235-243
2010
-
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-
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5
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1
1
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701467
Trinh
Structures of alternatively sp ...
Homo sapiens
Acta Crystallogr. Sect. D
65
201-211
2009
-
-
1
1
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-
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2
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1
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2
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1
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1
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1
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1
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2
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1
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706706
Springer
Tissue expression of ketohexok ...
Felis catus
Res. Vet. Sci.
87
115-117
2009
-
-
-
-
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1
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2
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7
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1
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1
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7
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1
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674062
Giroix
Fructokinase activity in rat l ...
Rattus norvegicus
Int. J. Mol. Med.
17
517-522
2006
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1
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6
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1
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4
6
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1
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-
682791
Hwa
The expression of ketohexokina ...
Homo sapiens
Proteomics
6
1077-1084
2006
-
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-
-
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-
1
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2
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2
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1
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2
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2
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-
678985
Funari
Genes required for fructose me ...
Homo sapiens, Mus musculus
Brain Res. Mol. Brain Res.
142
115-122
2005
-
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-
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2
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12
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12
-
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-
-
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-
660306
Geigenberger
Heterologous expression of a k ...
Rattus norvegicus
Planta
218
569-578
2004
-
-
1
-
1
-
-
-
-
-
-
1
-
5
-
-
-
-
-
5
1
-
1
-
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-
-
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-
-
-
1
-
-
1
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1
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5
1
-
1
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-
-
-
-
-
-
-
-
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-
-
641285
Asipu
Properties of normal and mutan ...
Homo sapiens
Diabetes
52
2426-2432
2003
-
-
-
-
2
-
-
16
-
1
-
1
-
2
-
-
-
-
-
-
-
-
5
-
-
-
2
12
-
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-
-
-
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-
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-
-
2
-
-
-
-
16
-
1
-
1
-
-
-
-
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-
-
-
5
-
-
-
2
12
-
-
-
-
-
-
-
-
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-
641284
Kozak
Expression, purification and p ...
Homo sapiens
Acta Crystallogr. Sect. D
57
586-588
2001
-
-
1
1
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-
-
-
-
1
-
1
-
2
-
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-
-
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-
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1
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1
-
1
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1
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-
641283
Hayward
Molecular genetics of the huma ...
Homo sapiens
Biochem. Soc. Trans.
25
140-145
1997
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-
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1
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1
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1
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1
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1
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727726
Rangaswamy
Ketohexokinase (ATP:D-fructose ...
Haloarcula vallismortis, Haloarcula vallismortis ATCC 34679
J. Bacteriol.
176
5505-5512
1994
-
-
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-
2
5
2
-
5
2
2
-
8
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1
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4
-
1
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2
-
1
1
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2
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2
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5
2
2
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5
2
2
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1
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4
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1
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2
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1
1
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4933
Bais
The purification and propertie ...
Homo sapiens
Biochem. J.
230
53-60
1985
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2
2
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2
1
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2
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1
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6
1
1
3
1
1
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1
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1
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6
1
1
3
1
1
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641282
Phillips
The mechanism of guanosine tri ...
Rattus norvegicus
Biochem. J.
228
667-671
1985
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2
4
-
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1
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1
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1
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2
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641279
Raushel
Bovine liver fructokinase: pur ...
Bos taurus
Biochemistry
16
2169-2175
1977
-
-
-
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-
20
16
-
6
2
1
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1
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1
1
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1
1
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17
1
1
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1
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1
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20
-
16
-
6
2
1
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1
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1
1
-
17
1
1
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1
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1
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641278
Weiser
-
Estimation of fructokinase (ke ...
Mammalia
Methods Enzymol.
41B
61-63
1975
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1
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1
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2
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2
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1
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1
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1
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2
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2
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1
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1
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641281
Raushel
The substrate and anomeric spe ...
Bos taurus, Saccharomyces cerevisiae
J. Biol. Chem.
248
8174-8177
1973
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1
10
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2
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2
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1
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15
-
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1
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10
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2
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1
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15
-
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641277
Parks
Liver fructokinase ...
Bos taurus
J. Biol. Chem.
227
231-242
1957
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2
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7
-
1
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1
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1
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1
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4
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1
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2
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7
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1
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1
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1
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4
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1
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641276
Hers
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La fructokinase du foie ...
Bos taurus
Biochim. Biophys. Acta
8
416-423
1952
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3
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1
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641275
Cori
The metabolism of fructose in ...
Rattus norvegicus
Biochim. Biophys. Acta
7
304-317
1951
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