BRENDA - Enzyme Database
show all sequences of 2.7.1.3

The mechanism of guanosine triphosphate depletion in the liver after a fructose load. The role of fructokinase

Phillips, M.I.; Davies, D.R.; Biochem. J. 228, 667-671 (1985)

Data extracted from this reference:

Inhibitors
Inhibitors
Commentary
Organism
Structure
ADP
-
Rattus norvegicus
GDP
-
Rattus norvegicus
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.56
-
D-fructose
pH 7.4, cosubstrate GTP
Rattus norvegicus
0.83
-
D-fructose
pH 7.4, + ATP
Rattus norvegicus
1.43
-
ATP
pH 7.4
Rattus norvegicus
1.53
-
GTP
pH 7.4
Rattus norvegicus
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ATP + D-fructose
Rattus norvegicus
-
ADP + D-fructose 1-phosphate
-
-
-
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Rattus norvegicus
-
-
-
Purification (Commentary)
Commentary
Organism
-
Rattus norvegicus
Source Tissue
Source Tissue
Commentary
Organism
Textmining
liver
-
Rattus norvegicus
-
Storage Stability
Storage Stability
Organism
-20C, stable for several months
Rattus norvegicus
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ATP + D-fructose
-
641282
Rattus norvegicus
ADP + D-fructose 1-phosphate
-
-
-
-
GTP + D-fructose
-
641282
Rattus norvegicus
?
-
-
-
?
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
ADP
-
Rattus norvegicus
GDP
-
Rattus norvegicus
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.56
-
D-fructose
pH 7.4, cosubstrate GTP
Rattus norvegicus
0.83
-
D-fructose
pH 7.4, + ATP
Rattus norvegicus
1.43
-
ATP
pH 7.4
Rattus norvegicus
1.53
-
GTP
pH 7.4
Rattus norvegicus
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ATP + D-fructose
Rattus norvegicus
-
ADP + D-fructose 1-phosphate
-
-
-
Purification (Commentary) (protein specific)
Commentary
Organism
-
Rattus norvegicus
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
liver
-
Rattus norvegicus
-
Storage Stability (protein specific)
Storage Stability
Organism
-20C, stable for several months
Rattus norvegicus
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ATP + D-fructose
-
641282
Rattus norvegicus
ADP + D-fructose 1-phosphate
-
-
-
-
GTP + D-fructose
-
641282
Rattus norvegicus
?
-
-
-
?
Other publictions for EC 2.7.1.3
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
737995
Li
Fructokinase A acts as a prote ...
Homo sapiens
Cell Cycle
15
2689-2690
2016
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1
1
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-
739133
Li
A splicing switch from ketohex ...
Homo sapiens
Nat. Cell Biol.
18
561-571
2016
-
1
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2
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739450
Le
Bioactivity-guided identificat ...
Homo sapiens
PLoS ONE
11
e0157458
2016
-
-
-
-
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6
-
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7
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1
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4
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4
6
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1
-
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-
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-
-
-
-
-
-
-
-
-
-
-
-
737891
Kavitha
Pharmacophore modeling, virtua ...
Homo sapiens
BioSystems
138
39-52
2015
-
1
-
-
-
-
-
-
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1
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-
-
-
-
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-
-
1
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-
-
-
-
-
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-
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-
-
-
-
-
-
-
721134
Maryanoff
Inhibitors of ketohexokinase: ...
Homo sapiens
ACS Med. Chem. Lett.
2
538-543
2011
-
-
-
-
-
-
48
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
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-
48
-
-
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48
48
-
-
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-
-
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-
1
-
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
723348
Diggle
Both isoforms of ketohexokinas ...
Mus musculus
Physiol. Genomics
42 A
235-243
2010
-
-
-
-
-
-
-
-
-
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-
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5
-
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-
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-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
701467
Trinh
Structures of alternatively sp ...
Homo sapiens
Acta Crystallogr. Sect. D
65
201-211
2009
-
-
1
1
-
-
-
-
-
-
-
-
-
2
-
-
1
-
-
2
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
2
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
706706
Springer
Tissue expression of ketohexok ...
Felis catus
Res. Vet. Sci.
87
115-117
2009
-
-
-
-
-
-
-
-
-
-
1
-
-
2
-
-
-
-
-
7
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
7
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
674062
Giroix
Fructokinase activity in rat l ...
Rattus norvegicus
Int. J. Mol. Med.
17
517-522
2006
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
4
6
-
-
-
-
1
-
-
-
-
-
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-
-
-
-
-
-
-
-
-
-
-
1
-
-
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-
-
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-
4
6
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
682791
Hwa
The expression of ketohexokina ...
Homo sapiens
Proteomics
6
1077-1084
2006
-
-
-
-
-
-
-
-
-
-
1
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-
2
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2
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2
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-
1
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-
-
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-
2
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
678985
Funari
Genes required for fructose me ...
Homo sapiens, Mus musculus
Brain Res. Mol. Brain Res.
142
115-122
2005
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
12
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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-
-
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-
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-
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12
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
660306
Geigenberger
Heterologous expression of a k ...
Rattus norvegicus
Planta
218
569-578
2004
-
-
1
-
1
-
-
-
-
-
-
1
-
5
-
-
-
-
-
5
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
5
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
641285
Asipu
Properties of normal and mutan ...
Homo sapiens
Diabetes
52
2426-2432
2003
-
-
-
-
2
-
-
16
-
1
-
1
-
2
-
-
-
-
-
-
-
-
5
-
-
-
2
12
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
16
-
1
-
1
-
-
-
-
-
-
-
-
5
-
-
-
2
12
-
-
-
-
-
-
-
-
-
-
641284
Kozak
Expression, purification and p ...
Homo sapiens
Acta Crystallogr. Sect. D
57
586-588
2001
-
-
1
1
-
-
-
-
-
1
-
1
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
641283
Hayward
Molecular genetics of the huma ...
Homo sapiens
Biochem. Soc. Trans.
25
140-145
1997
-
-
-
-
-
-
-
-
-
1
-
1
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
727726
Rangaswamy
Ketohexokinase (ATP:D-fructose ...
Haloarcula vallismortis, Haloarcula vallismortis ATCC 34679
J. Bacteriol.
176
5505-5512
1994
-
-
-
-
-
2
5
2
-
5
2
2
-
8
-
-
1
-
-
-
-
-
4
-
1
-
2
-
1
1
-
-
2
-
-
-
-
-
-
-
-
2
-
5
2
2
-
5
2
2
-
-
-
1
-
-
-
-
4
-
1
-
2
-
1
1
-
-
-
-
-
-
-
-
4933
Bais
The purification and propertie ...
Homo sapiens
Biochem. J.
230
53-60
1985
-
-
-
-
-
-
2
2
-
-
2
1
-
2
-
-
1
-
-
6
1
1
3
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
2
-
-
2
1
-
-
-
1
-
6
1
1
3
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
641282
Phillips
The mechanism of guanosine tri ...
Rattus norvegicus
Biochem. J.
228
667-671
1985
-
-
-
-
-
-
2
4
-
-
-
1
-
1
-
-
1
-
-
1
-
1
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
4
-
-
-
1
-
-
-
1
-
1
-
1
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
641279
Raushel
Bovine liver fructokinase: pur ...
Bos taurus
Biochemistry
16
2169-2175
1977
-
-
-
-
-
-
20
16
-
6
2
1
-
1
-
-
1
1
-
1
1
-
17
1
1
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
20
-
16
-
6
2
1
-
-
-
1
-
1
1
-
17
1
1
-
-
-
1
-
-
1
-
-
-
-
-
-
641278
Weiser
-
Estimation of fructokinase (ke ...
Mammalia
Methods Enzymol.
41B
61-63
1975
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
2
-
-
2
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
2
-
-
2
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
641281
Raushel
The substrate and anomeric spe ...
Bos taurus, Saccharomyces cerevisiae
J. Biol. Chem.
248
8174-8177
1973
-
-
-
-
-
-
1
10
-
-
-
2
-
2
-
-
-
-
-
1
-
-
15
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
10
-
-
-
2
-
-
-
-
-
1
-
-
15
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
641277
Parks
Liver fructokinase ...
Bos taurus
J. Biol. Chem.
227
231-242
1957
-
-
-
-
-
-
2
-
-
7
-
1
-
1
-
-
1
-
-
1
-
-
4
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
7
-
1
-
-
-
1
-
1
-
-
4
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
641276
Hers
-
La fructokinase du foie ...
Bos taurus
Biochim. Biophys. Acta
8
416-423
1952
-
-
-
-
-
-
-
1
-
3
-
1
-
1
-
-
-
-
-
1
-
-
3
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
3
-
1
-
-
-
-
-
1
-
-
3
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
641275
Cori
The metabolism of fructose in ...
Rattus norvegicus
Biochim. Biophys. Acta
7
304-317
1951
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