BRENDA - Enzyme Database show
show all sequences of 2.7.1.24

Crystal structure of dephospho-coenzyme A kinase from Haemophilus influenzae

Obmolova, G.; Teplyakov, A.; Bonander, N.; Eisenstein, E.; Howard, A.J.; Gilliland, G.L.; J. Struct. Biol. 136, 119-125 (2001)

Data extracted from this reference:

Cloned(Commentary)
Commentary
Organism
-
Haemophilus influenzae
Crystallization (Commentary)
Crystallization
Organism
in complex with ATP, structure determination and analysis
Haemophilus influenzae
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ATP + dephospho-CoA
Haemophilus influenzae
last step of coenzyme A biosynthesis: phosphorylation of the 3'-OH group of the ribose sugar moiety
ADP + CoA
-
-
-
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Haemophilus influenzae
P44920
-
-
Reaction
Reaction
Commentary
Organism
ATP + 3'-dephospho-CoA = ADP + CoA
active site, mechanism
Haemophilus influenzae
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ATP + dephospho-CoA
-
645080
Haemophilus influenzae
ADP + CoA
-
-
-
-
ATP + dephospho-CoA
last step of coenzyme A biosynthesis: phosphorylation of the 3'-OH group of the ribose sugar moiety
645080
Haemophilus influenzae
ADP + CoA
-
-
-
-
Cloned(Commentary) (protein specific)
Commentary
Organism
-
Haemophilus influenzae
Crystallization (Commentary) (protein specific)
Crystallization
Organism
in complex with ATP, structure determination and analysis
Haemophilus influenzae
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ATP + dephospho-CoA
Haemophilus influenzae
last step of coenzyme A biosynthesis: phosphorylation of the 3'-OH group of the ribose sugar moiety
ADP + CoA
-
-
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ATP + dephospho-CoA
-
645080
Haemophilus influenzae
ADP + CoA
-
-
-
-
ATP + dephospho-CoA
last step of coenzyme A biosynthesis: phosphorylation of the 3'-OH group of the ribose sugar moiety
645080
Haemophilus influenzae
ADP + CoA
-
-
-
-
Other publictions for EC 2.7.1.24
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
737383
Yu
Crystallization and preliminar ...
Legionella pneumophila
Acta Crystallogr. Sect. F
70
608-610
2014
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1
1
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1
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1
1
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738857
Lee
Characterization of dephosphoc ...
Streptomyces peucetius, Streptomyces peucetius ATCC 27952
J. Microbiol. Biotechnol.
24
1238-1244
2014
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1
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4
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1
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1
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738931
Gong
Crystal structure of Legionell ...
Legionella pneumophila
J. Struct. Biol.
188
233-239
2014
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1
1
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1
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-
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722282
Gudkova
EDC4 interacts with and regula ...
Homo sapiens
FEBS Lett.
586
3590-3595
2012
-
-
-
-
-
-
1
-
-
-
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-
-
2
-
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1
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1
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1
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1
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1
-
-
-
-
-
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-
-
-
-
723528
Walia
Identification of critical res ...
Mycobacterium tuberculosis
PLoS ONE
6
e15228
2011
-
-
1
-
8
-
-
15
-
-
-
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
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15
-
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1
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-
8
-
-
-
-
15
-
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-
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-
-
-
-
-
-
1
-
-
-
-
15
-
-
-
-
-
-
-
-
15
15
723532
Walia
Insights into the regulatory c ...
Mycobacterium tuberculosis
PLoS ONE
6
e21390
2011
-
-
-
-
-
-
1
-
-
-
2
-
-
3
-
-
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-
1
1
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-
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-
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-
1
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2
-
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
671313
Wadler
Dephospho-CoA kinase provides ...
Aquifex aeolicus, Escherichia coli, Homo sapiens
Anal. Biochem.
368
17-23
2007
-
3
2
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
1
-
2
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2
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3
2
2
-
-
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-
1
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
672562
Hwang
Enzymatic and cellular study o ...
Homo sapiens
Bioorg. Med. Chem.
15
2147-2155
2007
-
-
-
-
-
-
-
-
-
-
-
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-
4
-
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-
2
-
-
-
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-
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-
1
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-
1
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-
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-
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-
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-
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-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
663357
Seto
ATP-induced structural change ...
Thermus thermophilus, Thermus thermophilus HB8 / ATCC 27634 / DSM 579
Proteins
58
235-242
2005
-
-
1
1
-
-
-
-
-
-
1
2
-
94
-
-
1
-
-
-
-
-
4
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
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-
1
2
-
-
-
1
-
-
-
-
4
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
645079
O'Toole
Crystal structure of a trimeri ...
Escherichia coli
Protein Sci.
12
327-336
2003
-
-
1
1
-
-
-
-
-
-
2
1
-
4
-
-
1
1
-
-
-
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
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-
2
1
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-
1
-
-
-
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
643189
Aghajanian
Identification and characteriz ...
Homo sapiens, Sus scrofa
Biochem. J.
365
13-18
2002
-
-
1
-
-
-
-
4
1
-
3
-
-
6
-
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2
-
-
4
-
-
2
1
2
-
-
-
2
-
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1
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4
1
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3
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2
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4
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2
1
2
-
-
-
2
-
-
-
-
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-
-
-
-
645077
Mishra
Identification of yacE (coaE) ...
Corynebacterium ammoniagenes, Escherichia coli
J. Bacteriol.
183
2774-2778
2001
-
-
2
-
-
-
-
2
-
-
3
1
-
5
-
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1
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2
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3
2
1
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2
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2
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2
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3
1
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1
-
-
2
-
3
2
1
-
-
-
2
-
-
-
-
-
-
-
-
-
645080
Obmolova
Crystal structure of dephospho ...
Haemophilus influenzae
J. Struct. Biol.
136
119-125
2001
-
-
1
1
-
-
-
-
-
-
-
1
-
1
-
-
-
1
-
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-
-
2
-
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1
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1
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1
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-
-
2
-
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-
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-
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-
-
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-
643183
Martin
Separate enzymes catalyze the ...
Corynebacterium ammoniagenes
Biochem. Biophys. Res. Commun.
192
1155-1161
1993
-
-
-
-
-
-
-
-
1
-
-
1
-
1
-
-
1
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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-
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-
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-
-
1
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-
1
-
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-
1
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
643178
Worrall
Limited proteolysis of pig liv ...
Sus scrofa
FEBS Lett.
187
277-279
1985
-
-
-
-
-
-
-
-
-
-
2
-
-
1
-
-
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-
-
1
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-
1
1
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-
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-
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2
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1
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1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
4412
Nishimura
-
Mechanism of coenzyme A biosyn ...
Micrococcus luteus
J. Ferment. Technol.
61
95-99
1983
-
-
-
-
-
-
-
-
1
1
-
1
-
1
-
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-
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-
1
-
1
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-
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1
1
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1
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1
-
1
-
-
-
-
-
-
-
-
-
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-
-
-
-
643177
Worrall
A bifunctional enzyme complex ...
Sus scrofa
Biochem. J.
215
153-157
1983
-
-
-
-
-
-
-
-
1
-
2
-
-
2
-
-
1
-
-
2
1
1
1
1
1
-
-
-
-
-
-
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-
1
-
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-
-
-
-
-
-
-
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-
1
-
2
-
-
-
-
1
-
2
1
1
1
1
1
-
-
-
-
-
-
1
-
-
-
-
-
-
643180
Skrede
Mitochondrial pantetheinephosp ...
Rattus norvegicus
Eur. J. Biochem.
131
57-63
1983
-
-
-
-
-
-
1
1
2
1
-
1
-
1
-
-
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-
1
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2
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-
1
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1
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1
2
1
-
1
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-
1
-
-
2
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
643179
Skrede
Mitochondrial biosynthesis of ...
Rattus norvegicus
Biochem. Biophys. Res. Commun.
91
1536-1542
1979
-
-
-
-
-
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-
3
2
1
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-
1
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-
1
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1
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1
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-
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1
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3
2
1
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1
-
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1
-
1
-
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-
1
-
-
-
-
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-
-
-
-
4410
Brohn
Coenzyme A requirement of mala ...
Anas platyrhynchos, no activity in Plasmodium lophurae
Proc. Natl. Acad. Sci. USA
72
2456-2458
1975
-
-
-
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1
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2
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1
1
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1
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1
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1
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1
1
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1
-
1
-
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-
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-
643176
Abiko
-
Pantothenic acid and coenzyme ...
Rattus norvegicus
Methods Enzymol.
18A
358-364
1970
1
-
-
-
-
-
1
2
1
1
-
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-
1
-
-
1
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-
1
1
-
2
-
1
-
3
-
1
-
3
-
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-
-
1
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-
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1
-
2
1
1
-
-
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-
1
-
1
1
-
2
-
1
-
3
-
1
-
3
-
-
-
-
-
-
-
643174
Hoagland
Biosynthesis of coenzyme A fro ...
Columba sp., Rattus norvegicus, Sus scrofa
J. Biol. Chem.
207
767-773
1954
3
-
-
-
-
-
-
-
6
6
-
-
-
3
-
-
1
-
-
3
-
1
3
-
3
-
-
-
3
-
-
-
-
-
-
3
-
-
-
-
-
-
-
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-
-
6
6
-
-
-
-
-
1
-
3
-
1
3
-
3
-
-
-
3
-
-
-
-
-
-
-
-
-
645067
Wang
Kinases for the synthesis of c ...
Anas platyrhynchos, Columba sp.
J. Biol. Chem.
206
311-325
1954
2
-
-
-
-
1
1
1
2
2
-
-
-
2
-
-
1
-
-
2
1
1
6
-
2
-
-
-
1
-
-
2
-
-
-
2
-
-
2
-
-
1
-
1
-
1
2
2
-
-
-
-
-
1
-
2
1
1
6
-
2
-
-
-
1
-
-
-
-
-
-
-
-
-
643175
Novelli
Enzymatic synthesis and struct ...
Columba sp., Rattus norvegicus, Sus scrofa
Fed. Proc.
12
675-681
1953
-
-
-
-
-
-
-
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3
-
3
-
3
-
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4
-
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3
-
3
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4
-
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