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Literature summary for 2.7.1.23 extracted from

  • Rabani, R.; Cossette, C.; Graham, F.; Powell, W.S.
    Protein kinase C activates NAD kinase in human neutrophils (2020), Free Radic. Biol. Med., 161, 50-59 .
    View publication on PubMed
Search for more literature for 2.7.1.23

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + NAD+ Homo sapiens the enzyme is required for the de novo synthesis of NADP+ from NAD+ ADP + NADP+
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens O95544
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein phosphorylation of NAD+ kinase by a protein kinase C isoform, possibly PKCdelta, in stimulated neutrophils results in a rapid increase in its activity Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
neutrophil
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + NAD+
-
 Homo sapiens ADP + NADP+
-
 ?
ATP + NAD+ the enzyme is required for the de novo synthesis of NADP+ from NAD+ Homo sapiens ADP + NADP+
-
 ?

Synonyms

Synonyms Comment Organism
NADK
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function the enzyme is required for the de novo synthesis of NADP+ from NAD+. In neutrophils, the enzyme plays an essential role by providing sufficient levels of NADPH to support a robust oxidative burst Homo sapiens