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Literature summary for 2.7.1.22 extracted from

  • Khan, J.A.; Xiang, S.; Tong, L.
    Crystal structure of human nicotinamide riboside kinase (2007), Structure, 15, 1005-1013.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Homo sapiens

Crystallization (Commentary)

Crystallization (Comment) Organism
sitting-drop vapor-diffusion method at 22°C, crystal structures of NRK1 in a binary complex with the reaction product nicotinamide mononucleotide at 1.5 A resolution and in a ternary complex with ADP and tiazofurin at 2.7 A resolution. The active site is located in a groove between the central parallel beta sheet core and the LID and NMP-binding domains Homo sapiens

Protein Variants

Protein Variants Comment Organism
D138A mutation has minor effects on catalysis Homo sapiens
D36A mutation abolishes activity Homo sapiens
D56A mutation abolishes activity Homo sapiens
K16A mutation abolishes activity Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9NWW9
-
-

Purification (Commentary)

Purification (Comment) Organism
recombinant enzyme Homo sapiens

Synonyms

Synonyms Comment Organism
nicotinamide riboside kinase
-
Homo sapiens
NRK1
-
Homo sapiens