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Literature summary for 2.7.1.216 extracted from

  • Bentinger, M.; Gruenler, J.; Peterson, E.; Swiezewska, E.; Dallner, G.
    Phosphorylation of farnesol in rat liver microsomes: properties of farnesol kinase and farnesyl phosphate kinase (1998), Arch. Biochem. Biophys., 353, 191-198.
    View publication on PubMed
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Inhibitors

Inhibitors Comment Organism Structure
CHAPS 0.1%, about 50% inhibition Rattus norvegicus
deoxycholate 0.05%, almost complete inhibition Rattus norvegicus
EDTA 1 mM, about 50% loss of activity Rattus norvegicus
EGTA 1 mM, about 50% loss of activity Rattus norvegicus
octyl beta-D-glucopyranoside 0.1%, about 50% inhibition Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0023
-
 (2E,6E)-farnesol pH 7.2, 37°C Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome rough and smooth I microsome, the enzmye is associated with the inner, luminal surface of the vesicles Rattus norvegicus
-
-
additional information not found in smooth II microsomes, mitochondria, peroxisomes, Golgi, or plasma membranes Rattus norvegicus
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ 2 mM, about 2fold activation Rattus norvegicus
Mn2+ 5 mM, optimum concentratzion, about 4fold activation Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + (2E,6E)-farnesol ATP, best phosphate donor Rattus norvegicus ADP + (2E,6E)-farnesyl phosphate
-
 ?
CTP + (2E,6E)-farnesol
-
 Rattus norvegicus CDP + (2E,6E)-farnesyl phosphate
-
 ?
GTP + (2E,6E)-farnesol
-
 Rattus norvegicus GDP + (2E,6E)-farnesyl phosphate
-
 ?