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Literature summary for 2.7.1.213 extracted from
- A pentose bisphosphate pathway for nucleoside degradation in Archaea (2015), Nat. Chem. Biol., 11, 355-360.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| cytidine | substrate inhibition | Thermococcus kodakarensis |  |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 1.71 | - |
cytidine | pH and temperature not specified in the publication | Thermococcus kodakarensis | |
| 4.11 | - |
3'-deoxycytidine | pH and temperature not specified in the publication | Thermococcus kodakarensis | |
| 5.72 | - |
ATP | pH and temperature not specified in the publication | Thermococcus kodakarensis | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Co2+ | 26% activity compared to Mg2+ | Thermococcus kodakarensis | |
| KCl | 300 mM, 3.6fold increase of activity | Thermococcus kodakarensis | |
| Mg2+ | most preferred divalent metal ion | Thermococcus kodakarensis | |
| Mn2+ | 68% activity compared to Mg2+ | Thermococcus kodakarensis | |
| additional information | ca2+, Ni2+, Zn2+, cu2+ show less than 20% avtivation | Thermococcus kodakarensis |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| cytidine + ATP | Thermococcus kodakarensis | - |
CMP + ADP | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Thermococcus kodakarensis | Q5JEK6 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3'-deoxycytidine + ATP | - |
Thermococcus kodakarensis | 3'-dCMP + ADP | - |
? | |
| cytidine + ATP | - |
Thermococcus kodakarensis | CMP + ADP | - |
? | |
| cytidine + CTP | 30% activity with CTP compared to ATP | Thermococcus kodakarensis | CMP + CDP | - |
? | |
| cytidine + GTP | 70% activity with GTP compared to ATP | Thermococcus kodakarensis | CMP + GDP | - |
? | |
| cytidine + UTP | 30% activity with UTP compared to ATP | Thermococcus kodakarensis | CMP + UDP | - |
? | |
| uridine + ATP | - |
Thermococcus kodakarensis | UMP + ADP | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| TK1843 | locus name | Thermococcus kodakarensis |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 90 | - |
- |
Thermococcus kodakarensis |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 222 | - |
ATP | pH and temperature not specified in the publication | Thermococcus kodakarensis | |
| 226 | - |
3'-deoxycytidine | pH and temperature not specified in the publication | Thermococcus kodakarensis | |
| 280 | - |
cytidine | pH and temperature not specified in the publication | Thermococcus kodakarensis | |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 5 | 9 | - |
Thermococcus kodakarensis |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 29.3 | - |
cytidine | pH and temperature not specified in the publication | Thermococcus kodakarensis | |
kcat/KM [mM/s]
| kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 38.8 | - |
ATP | pH and temperature not specified in the publication | Thermococcus kodakarensis | |
| 55 | - |
3'-deoxycytidine | pH and temperature not specified in the publication | Thermococcus kodakarensis | |
| 164 | - |
cytidine | pH and temperature not specified in the publication | Thermococcus kodakarensis | |
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