BRENDA - Enzyme Database show
show all sequences of 2.7.1.21

Isolation and characterization of Dictyostelium thymidine kinase 1 as a calmodulin-binding protein

O'Day, D.H.; Chatterjee-Chakraborty, M.; Wagler, S.; Myre, M.A.; Biochem. Biophys. Res. Commun. 331, 1494-1502 (2005)

Data extracted from this reference:

Activating Compound
Activating Compound
Commentary
Organism
Structure
Calmodulin
stimulates the enzyme by 13.8%, might modify the activity, enzyme contains a calmodulin binding domain, Ca2+ is required for binding, compounds W7 and W13 prevent stimulation, overview
Dictyostelium discoideum
Cloned(Commentary)
Commentary
Organism
gene thyB, DNA and amino acid sequence determination and analysis, phage display, location on chromosome 5, 3 exons, 2 introns, expression in Escherichia coli strain BL21
Dictyostelium discoideum
Inhibitors
Inhibitors
Commentary
Organism
Structure
W7
slight inhibitory in presence of calmodulin
Dictyostelium discoideum
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
cytosol
-
Dictyostelium discoideum
5829
-
additional information
enzyme possesses no nuclear or transmembrane sequences
Dictyostelium discoideum
-
-
Metals/Ions
Metals/Ions
Commentary
Organism
Structure
Ca2+
calmodulin binding binding is dependent on Ca2+
Dictyostelium discoideum
Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
25494
-
x * 25494, recombinant enzyme, amino acid sequence calculation
Dictyostelium discoideum
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ATP + thymidine
Dictyostelium discoideum
-
ADP + thymidine 5'-phosphate
-
-
ir
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Dictyostelium discoideum
Q27564
-
-
Purification (Commentary)
Commentary
Organism
recombinant enzyme partially utilizing calmodulin-agarose-beads
Dictyostelium discoideum
Source Tissue
Source Tissue
Commentary
Organism
Textmining
additional information
enzyme is expressed during growth, but decreases in amount after starvation
Dictyostelium discoideum
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ATP + thymidine
-
660905
Dictyostelium discoideum
ADP + thymidine 5'-phosphate
-
-
-
ir
Subunits
Subunits
Commentary
Organism
?
x * 25494, recombinant enzyme, amino acid sequence calculation
Dictyostelium discoideum
More
enzyme contains a calmodulin binding domain
Dictyostelium discoideum
Temperature Optimum [°C]
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
37
-
assay at
Dictyostelium discoideum
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
7.5
-
assay at
Dictyostelium discoideum
Cofactor
Cofactor
Commentary
Organism
Structure
ATP
P-loop binding site
Dictyostelium discoideum
Activating Compound (protein specific)
Activating Compound
Commentary
Organism
Structure
Calmodulin
stimulates the enzyme by 13.8%, might modify the activity, enzyme contains a calmodulin binding domain, Ca2+ is required for binding, compounds W7 and W13 prevent stimulation, overview
Dictyostelium discoideum
Cloned(Commentary) (protein specific)
Commentary
Organism
gene thyB, DNA and amino acid sequence determination and analysis, phage display, location on chromosome 5, 3 exons, 2 introns, expression in Escherichia coli strain BL21
Dictyostelium discoideum
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
ATP
P-loop binding site
Dictyostelium discoideum
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
W7
slight inhibitory in presence of calmodulin
Dictyostelium discoideum
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
cytosol
-
Dictyostelium discoideum
5829
-
additional information
enzyme possesses no nuclear or transmembrane sequences
Dictyostelium discoideum
-
-
Metals/Ions (protein specific)
Metals/Ions
Commentary
Organism
Structure
Ca2+
calmodulin binding binding is dependent on Ca2+
Dictyostelium discoideum
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
25494
-
x * 25494, recombinant enzyme, amino acid sequence calculation
Dictyostelium discoideum
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ATP + thymidine
Dictyostelium discoideum
-
ADP + thymidine 5'-phosphate
-
-
ir
Purification (Commentary) (protein specific)
Commentary
Organism
recombinant enzyme partially utilizing calmodulin-agarose-beads
Dictyostelium discoideum
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
additional information
enzyme is expressed during growth, but decreases in amount after starvation
Dictyostelium discoideum
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ATP + thymidine
-
660905
Dictyostelium discoideum
ADP + thymidine 5'-phosphate
-
-
-
ir
Subunits (protein specific)
Subunits
Commentary
Organism
?
x * 25494, recombinant enzyme, amino acid sequence calculation
Dictyostelium discoideum
More
enzyme contains a calmodulin binding domain
Dictyostelium discoideum
Temperature Optimum [°C] (protein specific)
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
37
-
assay at
Dictyostelium discoideum
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
7.5
-
assay at
Dictyostelium discoideum
Other publictions for EC 2.7.1.21
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
737937
Jagarlamudi
Breast and prostate cancer pat ...
Homo sapiens
BMC Cancer
15
66
2015
-
1
-
-
-
-
-
-
-
-
1
-
-
2
-
-
-
-
-
5
-
-
-
1
-
-
-
-
-
-
-
-
-
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-
1
-
-
-
-
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1
-
-
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-
-
-
5
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
739404
Timm
Structural and kinetic charact ...
Leishmania major
PLoS Negl. Trop. Dis.
9
e0003781
2015
-
-
1
1
-
-
3
8
-
-
1
-
-
4
-
-
-
-
-
-
1
1
7
1
-
-
-
7
1
-
-
-
-
-
3
-
-
1
-
1
-
-
3
3
-
8
-
-
1
-
-
-
-
-
-
-
1
1
7
1
-
-
-
7
1
-
-
-
-
-
-
-
7
7
750551
Zhang
Evaluation of the diagnostic ...
Homo sapiens
FEBS open bio
5
240-244
2015
-
1
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
-
-
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-
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1
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-
-
-
-
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-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
737955
Jagarlamudi
Properties of cellular and ser ...
Canis lupus familiaris
BMC Vet. Res.
10
228
2014
-
1
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
739508
Szantho
Serum thymidine kinase activit ...
Homo sapiens
PLoS ONE
9
e91647
2014
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
722197
Agarwal
Synthesis of N3-substituted ca ...
Homo sapiens
Eur. J. Med. Chem.
60
456-468
2013
-
-
1
-
-
-
-
9
-
-
-
-
-
2
-
-
-
-
-
-
-
-
23
-
-
-
-
9
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
9
-
-
-
-
-
-
-
-
-
-
-
-
23
-
-
-
-
9
-
-
-
-
-
-
-
-
-
-
722248
Mutahir
Thymidine kinase 1 regulatory ...
Anolis carolinensis, Arabidopsis thaliana, Bacillus cereus, Caenorhabditis elegans, Danio rerio, Dictyostelium discoideum, Gallus gallus, Homo sapiens, Rattus norvegicus, Xenopus tropicalis
FEBS J.
280
1531-1541
2013
-
-
10
-
-
-
-
21
1
-
24
-
-
16
-
-
-
-
-
-
-
-
10
10
-
-
-
-
-
-
-
-
-
-
-
-
-
10
-
-
-
-
-
-
-
21
1
-
24
-
-
-
-
-
-
-
-
-
10
10
-
-
-
-
-
-
-
-
-
-
-
-
-
-
722240
Skovgaard
Comparative active-site mutati ...
Caenorhabditis elegans, Homo sapiens
FEBS J.
279
1777-1787
2012
-
-
2
1
8
-
-
20
-
-
-
-
-
5
-
-
1
-
-
-
-
-
7
-
-
-
-
20
-
-
-
-
-
-
-
-
-
2
-
1
8
-
-
-
-
20
-
-
-
-
-
-
-
1
-
-
-
-
7
-
-
-
-
20
-
-
-
-
-
-
-
-
24
24
722246
Clausen
Two thymidine kinases and one ...
Arabidopsis thaliana
FEBS J.
279
3889-3897
2012
-
-
1
-
-
-
-
6
-
-
2
-
-
6
-
-
1
-
-
2
-
-
3
1
-
-
-
6
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
6
-
-
2
-
-
-
-
1
-
2
-
-
3
1
-
-
-
6
-
-
-
-
-
1
1
-
6
6
722758
Ranjbarian
Trypanosoma brucei thymidine k ...
Trypanosoma brucei, Trypanosoma brucei TC221
J. Biol. Chem.
287
17628-17636
2012
4
-
1
-
-
-
1
14
-
-
-
-
-
5
-
-
1
-
-
-
-
-
17
1
-
-
-
11
1
-
-
-
-
-
-
4
-
1
-
-
-
-
-
1
-
14
-
-
-
-
-
-
-
1
-
-
-
-
17
1
-
-
-
11
1
-
-
-
-
-
-
-
11
11
723305
Mutahir
Characterization of oligomeric ...
Solanum lycopersicum
Nucleosides Nucleotides Nucleic Acids
30
1223-1226
2011
-
1
1
-
-
-
-
-
-
-
3
-
-
3
-
-
-
-
-
-
-
-
3
1
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
3
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
723324
Van Poecke
Synthesis, modeling and evalua ...
Homo sapiens
Org. Biomol. Chem.
9
892-901
2011
-
-
-
-
-
-
15
-
2
-
-
-
-
3
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
15
-
-
-
-
-
-
-
15
15
-
-
2
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
723765
Stepanenko
-
Cloning, expression, isolation ...
Human alphaherpesvirus 1, Human alphaherpesvirus 1 L2
Russ. J. Bioorg. Chem.
37
436-440
2011
-
-
1
-
-
-
1
-
-
-
2
-
-
2
-
-
1
-
-
-
-
2
16
1
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
2
-
-
-
-
1
-
-
-
2
16
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
723766
Guskova
-
Enzymatic activity of thymidin ...
Herpes simplex virus, Herpes simplex virus type-1
Russ. J. Bioorg. Chem.
37
560-563
2011
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
701752
Azab
Characterization of a thymidin ...
Equid alphaherpesvirus 4, Equid alphaherpesvirus 4 TH20p
Antiviral Res.
85
389-395
2010
-
-
-
-
-
-
-
-
-
-
-
2
-
6
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
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-
-
1
-
-
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-
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-
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-
2
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
2
2
-
-
-
721825
Lin
3-(1,2,3-Triazol-1-yl)-3-deoxy ...
Homo sapiens, Ureaplasma parvum
Bioorg. Med. Chem.
18
3261-3269
2010
-
-
-
-
-
-
20
-
-
-
-
-
-
5
-
-
2
-
-
-
-
-
22
-
-
-
-
-
-
-
-
-
-
-
20
-
-
-
-
-
-
-
20
20
-
-
-
-
-
-
-
-
-
2
-
-
-
-
22
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
722671
Sun
Prodrug activation by Cryptosp ...
Cryptosporidium parvum
J. Biol. Chem.
285
15916-15922
2010
3
-
1
-
-
-
1
8
-
-
2
-
-
4
-
-
1
-
-
-
-
-
16
1
-
-
-
8
-
-
-
-
-
-
-
3
-
1
-
-
-
-
-
1
-
8
-
-
2
-
-
-
-
1
-
-
-
-
16
1
-
-
-
8
-
-
-
-
-
-
-
-
8
8
722681
Chen
Regulation and functional cont ...
Homo sapiens
J. Biol. Chem.
285
27327-27335
2010
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
4
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
4
-
-
1
-
-
-
-
-
-
-
-
-
1
2
2
1
-
-
722909
Van Poecke
3-[4-Aryl-(1,2,3-triazol-1-yl) ...
Homo sapiens
J. Med. Chem.
53
2902-2912
2010
-
-
-
-
-
-
19
-
2
-
-
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
1
-
15
-
-
-
-
-
-
-
15
19
1
-
2
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
723301
Munch-Petersen
Enzymatic regulation of cytoso ...
Mus musculus
Nucleosides Nucleotides Nucleic Acids
29
363-369
2010
-
-
-
-
1
-
-
-
2
-
3
-
-
1
-
-
-
-
-
-
-
-
1
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
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-
2
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3
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1
2
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1
1
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723302
Sun
Identification and characteriz ...
Homo sapiens, Rattus norvegicus
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1
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6
2
3
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3
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2
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2
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4
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4
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4
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1
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6
4
2
3
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2
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2
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4
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2
2
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705803
Balzarini
Human mitochondrial thymidine ...
Homo sapiens, Human alphaherpesvirus 1
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1
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10
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-
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2
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-
-
-
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2
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30
-
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1
2
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10
-
30
30
-
12
7
-
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1
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-
-
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2
-
-
-
-
-
-
-
-
-
-
-
-
-
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706070
Lossani
Thymidine kinase and uridine-c ...
Entamoeba histolytica
Parasitology
136
595-602
2009
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1
-
-
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1
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2
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2
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1
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6
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1
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1
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10
-
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1
1
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10
11
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1
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2
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1
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-
-
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6
-
-
-
-
-
1
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684507
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Penciclovir is a potent inhibi ...
Felid alphaherpesvirus 1
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78
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-
-
-
-
-
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1
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-
-
-
-
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1
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-
-
-
-
-
-
-
-
-
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Saijo
Characterization and susceptib ...
Human alphaherpesvirus 1
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-
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1
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-
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1
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-
-
-
-
-
-
-
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-
-
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-
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-
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686196
van Calenbergh
-
From M. tuberculosis thymidine ...
Mycobacterium tuberculosis
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-
-
-
-
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1
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1
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-
-
-
-
-
-
-
-
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-
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-
-
-
-
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-
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1
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-
-
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-
-
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-
-
-
-
-
-
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Perez-Perez
Structure, physiological role, ...
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2
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1
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1
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2
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-
-
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2
2
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1
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1
-
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1
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Noninvasive imaging of cell pr ...
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1
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1
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1
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1
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Votava
Changes of serum thymidine kin ...
Homo sapiens
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2
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1
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2
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Diverse herpes simplex virus t ...
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1
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4
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A method to distinguish betwee ...
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1
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1
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1
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686992
Salama
Gene therapy of uterine leiomy ...
Mus musculus
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1
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-
-
-
-
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1
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-
-
-
-
-
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687950
Iqbal
Development and validation of ...
Herpes simplex virus
J. Chromatogr. B
846
281-290
2007
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-
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2
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1
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3
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3
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1
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2
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1
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-
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1
-
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3
-
-
-
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3
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-
-
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-
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688580
Desbouis
-
Synthesis of tricarbonyl rheni ...
Herpes simplex virus
J. Organomet. Chem.
692
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2007
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-
-
-
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1
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1
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-
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-
-
-
-
-
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688734
Smith
Biophysical characterization o ...
Vaccinia virus
J. Virol. Methods
142
151-158
2007
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1
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1
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1
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-
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1
-
-
-
-
-
-
-
-
-
-
-
-
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-
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1
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-
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1
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-
-
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1
-
-
-
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1
-
-
-
-
-
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748019
Lutz
Exploiting temperature-depend ...
Thermotoga maritima, Thermotoga maritima DSM 3109
J. Am. Chem. Soc.
129
8714-8715
2007
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1
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12
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1
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-
-
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14
1
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-
12
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
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-
12
-
-
-
-
-
-
-
1
-
-
-
-
14
1
-
-
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12
-
-
-
-
-
-
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-
12
12
671389
Prichard
Distinct thymidine kinases enc ...
cowpox virus, Human alphaherpesvirus 1
Antiviral Res.
71
1-6
2006
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-
-
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-
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2
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-
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-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
676240
Sandrini
Thymidine kinase diversity in ...
Arabidopsis thaliana, Bacillus cereus, Bacillus subtilis, Clostridium acetobutylicum, Clostridium perfringens, Deinococcus radiodurans, Escherichia coli, Gallus gallus, Homo sapiens, Listeria monocytogenes, Mus musculus, Salmonella enterica subsp. enterica serovar Typhi, Solanum lycopersicum, Staphylococcus aureus, Streptomyces coelicolor, Ureaplasma parvum, Xanthomonas campestris, Yersinia enterocolitica
Nucleosides Nucleotides Nucleic Acids
25
1153-1158
2006
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23
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-
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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676241
Clausen
Thymidine kinases in archaea ...
Ferroplasma acidarmanus, Ferroplasma acidarmanus Fer1, Halobacterium sp., Halobacterium sp. NRC-1, Pyrobaculum aerophilum, Pyrobaculum aerophilum IM2, Thermococcus kodakarensis, Thermoplasma acidophilum
Nucleosides Nucleotides Nucleic Acids
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21
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
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676243
Zhu
Effect of C-terminal of human ...
Homo sapiens
Nucleosides Nucleotides Nucleic Acids
25
1185-1188
2006
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1
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1
-
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1
2
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-
-
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2
-
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1
-
-
-
-
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1
-
-
-
1
1
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-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
1
2
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
676244
Solaroli
Substrate specificity of three ...
Canid alphaherpesvirus 1, Felid alphaherpesvirus 1, Vaccinia virus
Nucleosides Nucleotides Nucleic Acids
25
1189-1192
2006
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3
-
-
-
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6
-
-
-
-
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7
-
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3
-
-
-
-
-
7
-
-
-
-
7
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
6
-
-
-
-
-
-
-
3
-
-
-
-
7
-
-
-
-
7
-
-
-
-
-
-
-
-
-
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660722
Frobert
Herpes simplex virus thymidine ...
Human alphaherpesvirus 1
Antimicrob. Agents Chemother.
49
1055-1059
2005
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1
-
4
-
-
-
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1
-
2
-
2
-
-
1
1
-
-
-
-
3
-
1
-
-
-
1
-
-
1
-
-
-
-
-
1
1
-
4
-
-
-
-
-
-
1
-
2
-
-
-
1
-
-
-
-
3
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
660905
O'Day
Isolation and characterization ...
Dictyostelium discoideum
Biochem. Biophys. Res. Commun.
331
1494-1502
2005
1
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1
-
-
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1
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2
1
1
1
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6
-
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1
-
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1
-
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1
2
1
-
-
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1
-
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1
-
-
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1
-
1
1
-
-
-
-
1
-
-
2
1
1
1
-
-
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1
-
1
-
-
1
2
1
-
-
-
1
-
-
-
-
-
-
-
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-
661194
Wu
Characterization of three esse ...
Human gammaherpesvirus 4
Biochemistry
44
4785-4793
2005
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1
1
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7
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15
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3
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1
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3
-
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1
-
-
-
-
-
11
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1
-
-
14
1
-
-
5
-
-
-
-
1
1
5
-
7
-
-
-
-
15
-
3
-
1
-
-
-
1
-
-
-
-
11
-
1
-
-
14
1
-
-
-
-
-
-
-
-
-
661195
Barroso
Kinetic analysis and ligand-in ...
Homo sapiens
Biochemistry
44
4886-4896
2005
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1
-
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1
4
7
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1
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2
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3
-
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1
-
-
-
1
-
5
3
1
-
1
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1
-
-
1
-
-
-
-
-
1
1
-
-
1
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4
-
7
-
1
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2
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-
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1
-
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1
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5
3
1
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1
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1
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-
-
-
-
-
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661751
Birringer
Structure of a type II thymidi ...
Homo sapiens, Leishmania major, Mycoplasma pneumoniae, Vaccinia virus
FEBS Lett.
579
1376-1382
2005
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1
1
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4
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8
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4
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5
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4
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5
2
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-
-
-
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4
-
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-
-
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1
4
1
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-
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4
-
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5
8
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4
-
-
-
-
-
-
-
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5
2
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-
-
-
-
-
-
-
-
-
-
-
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673226
Perez-Perez
Mitochondrial thymidine kinase ...
Homo sapiens, Human alphaherpesvirus 1
Curr. Top. Med. Chem.
5
1205-1219
2005
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2
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97
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3
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98
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3
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101
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-
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6
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-
-
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-
-
-
-
-
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-
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660865
Li
Perturbation of ATP-induced te ...
Homo sapiens
Biochem. Biophys. Res. Commun.
313
587-593
2004
1
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1
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1
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1
2
2
1
2
3
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2
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1
1
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-
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1
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3
3
1
-
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2
1
-
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1
-
-
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1
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1
1
-
1
-
-
1
-
2
2
1
2
3
-
-
1
1
-
-
1
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3
3
1
-
-
2
1
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-
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661637
Frederiksen
Effect of valine 106 on struct ...
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Eur. J. Biochem.
271
2248-2256
2004
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1
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9
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12
2
1
3
1
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2
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1
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1
1
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3
2
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-
-
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1
-
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1
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-
-
-
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1
1
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9
-
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-
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12
2
1
3
1
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1
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1
1
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3
2
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-
-
1
-
-
-
-
-
-
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-
-
663222
Welin
Structures of thymidine kinase ...
Homo sapiens, Ureaplasma urealyticum
Proc. Natl. Acad. Sci. USA
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Tzeng
Chimeric polypeptide of thymid ...
Shrimp white spot syndrome virus
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641151
Connolly
Antibodies to Epstein-Barr vir ...
Human gammaherpesvirus 4
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641152
Zhang
A monoclonal antibody specific ...
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641153
Vogt
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Herpes simplex virus
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641157
Amrhein
Highly purified recombinant va ...
Human alphaherpesvirus 3
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1
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Valine, not methionine, is ami ...
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641160
Degreve
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641163
Hinds
Conservative mutations of glut ...
Herpes simplex virus
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641166
Prota
Kinetics and crystal structure ...
Herpes simplex virus
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Cloning and characterization o ...
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641154
Champness
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Herpes simplex virus
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Gustafson
The Epstein-Barr virus thymidi ...
Herpes simplex virus, Human gammaherpesvirus 4
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A continuous spectrophotometri ...
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Tsukifuji-Nabeya
Characterization of the purifi ...
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Pepper
Murine Gammaherpesvirus-68 enc ...
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The three-dimensional structur ...
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Mao
Synthesis of a photoaffinity a ...
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Roberts
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Kinyanjui
Thymidine kinase from Tetrahym ...
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Purification and characterizat ...
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2
1
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4
1
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641148
Insler
Independent characterization o ...
Hymenolepis diminuta
Comp. Biochem. Physiol. B
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181-186
1991
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1
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2
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1
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641121
Sanderson
Purification and crystallizati ...
Herpes simplex virus
J. Mol. Biol.
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1988
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1
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1
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1
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1
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1
-
-
-
-
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-
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-
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641122
Sherley
Human cytosolic thymidine kina ...
Homo sapiens
J. Biol. Chem.
263
375-382
1988
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-
-
-
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1
-
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2
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2
1
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3
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1
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1
1
1
2
1
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-
-
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-
1
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2
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2
1
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1
-
1
1
1
2
1
-
-
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-
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-
-
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-
641126
Bone
Inhibition of thymidine kinase ...
Homo sapiens
J. Biol. Chem.
261
5731-5735
1986
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2
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1
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1
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5
1
4
3
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2
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-
1
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-
-
-
-
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-
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641127
Kit
Thymidine kinase ...
Cytomegalovirus, Gallus gallus, Homo sapiens, Macaca mulatta polyomavirus 1
Microbiol. Sci.
2
369-375
1985
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5
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2
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1
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5
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2
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-
1
-
-
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-
641128
Waldman
Purification and characterizat ...
Herpes simplex virus
J. Biol. Chem.
258
11571-11575
1983
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-
1
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1
2
2
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1
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-
1
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4
1
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2
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1
1
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2
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-
1
-
-
-
1
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2
2
2
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-
2
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-
1
-
-
1
-
4
1
-
-
2
-
1
1
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-
-
-
-
-
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-
641129
Gan
Human thymidine kinase. Purifi ...
Homo sapiens
J. Biol. Chem.
258
7000-7004
1983
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-
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1
2
3
3
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1
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2
2
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6
1
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-
1
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-
1
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-
-
-
-
-
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1
2
3
3
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1
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2
2
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6
1
-
-
-
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1
-
-
1
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-
-
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-
-
641130
Chraibi
Characterization of the thymid ...
Physarum polycephalum
J. Biochem.
93
323-330
1983
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-
-
-
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11
1
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1
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2
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1
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2
1
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1
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1
1
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7
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-
11
7
1
-
1
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-
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1
-
2
1
-
1
-
-
-
-
-
1
1
-
-
-
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-
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-
-
641131
Ellims
Kinetic mechanism and inhibiti ...
Homo sapiens
Biochim. Biophys. Acta
660
238-242
1981
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-
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4
6
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2
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2
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4
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4
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4
4
6
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2
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2
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4
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641132
Sandlie
Mechanism of inhibition of thy ...
Escherichia coli
FEBS Lett.
110
223-226
1980
2
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-
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3
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2
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1
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1
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2
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3
1
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-
1
-
-
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641133
Ellims
Human liver thymidine kinase. ...
Homo sapiens
J. Biol. Chem.
255
11290-11295
1980
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-
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1
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2
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3
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2
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1
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2
1
1
1
1
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1
-
2
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1
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-
1
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2
-
3
-
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1
-
2
1
1
1
1
-
-
1
-
2
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-
1
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-
-
-
-
641134
Gröbner
Thymidine kinase enzyme varian ...
Physarum polycephalum
J. Biochem.
86
1607-1614
1979
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-
-
-
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4
4
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1
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2
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1
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1
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2
-
1
1
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2
3
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4
2
4
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-
1
-
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1
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-
1
-
-
-
2
-
1
1
-
3
-
-
-
-
-
-
641135
Swinton
-
Characterization of thymidine ...
Chlamydomonas reinhardtii
Mol. Gen. Genet.
175
399-409
1979
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-
-
-
-
-
7
2
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1
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1
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1
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-
1
4
-
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-
1
-
1
-
3
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-
-
-
-
-
-
-
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7
3
2
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1
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-
-
-
1
4
-
-
-
-
-
1
-
1
-
-
-
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-
-
-
641123
Chen
Thymidine kinase from Escheric ...
Escherichia coli
Methods Enzymol.
51
354-360
1978
5
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-
-
-
-
2
3
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2
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2
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1
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-
1
2
10
-
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-
1
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3
1
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-
5
-
-
3
-
-
-
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2
1
3
-
2
-
-
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-
1
-
-
1
2
10
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
641124
Bresnick
Deoxythymidine kinase in regen ...
Rattus norvegicus
Methods Enzymol.
51
360-365
1978
-
-
-
-
-
-
16
4
1
4
1
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1
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1
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-
1
1
-
9
-
-
-
-
-
1
-
-
-
3
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-
-
-
-
-
-
-
-
-
16
3
4
1
4
1
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-
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-
1
-
1
1
-
9
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
641125
Cheng
Thymidine kinase from blast ce ...
Homo sapiens
Methods Enzymol.
51
365-371
1978
-
-
-
-
-
2
2
4
2
6
2
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-
1
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1
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-
1
1
-
4
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
2
-
2
2
4
2
6
2
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-
1
-
1
1
-
4
-
-
-
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641136
Iwasuki
Purification and properties of ...
Escherichia virus T4
J. Biochem.
82
1347-1359
1977
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-
-
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1
5
1
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5
2
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1
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1
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-
1
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2
1
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-
1
-
1
1
-
-
2
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-
-
-
-
-
-
-
1
-
5
2
1
-
5
2
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-
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-
1
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-
1
-
2
1
-
-
1
-
1
1
-
-
-
-
-
-
-
-
641137
Rohde
Irreversible inhibition of thy ...
Escherichia coli
FEBS Lett.
82
118-120
1977
-
-
-
-
-
-
3
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-
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-
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2
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-
-
-
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-
-
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-
-
3
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-
-
-
-
-
-
-
-
-
-
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-
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-
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641139
Lee
Human deoxythymidine kinase. I ...
Homo sapiens
J. Biol. Chem.
251
2600-2604
1976
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-
-
-
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1
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2
6
2
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1
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1
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2
1
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1
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1
-
2
-
1
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-
-
-
-
-
-
-
-
-
-
-
1
-
-
2
6
2
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-
1
-
2
1
-
1
-
-
-
1
-
2
-
1
-
-
-
-
-
-
-
641140
Cheng
Deoxythymidine kinase induced ...
Herpes simplex virus
J. Biol. Chem.
251
2605-2610
1976
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-
-
-
-
1
1
-
2
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1
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1
-
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-
1
1
-
-
-
2
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-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
2
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-
-
-
-
1
-
-
-
1
1
-
-
-
2
-
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-
-
-
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-
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641138
Kit
Characterization of nucleoside ...
Anas sp., Gallus gallus
Arch. Biochem. Biophys.
169
66-76
1975
-
-
-
-
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6
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2
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1
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-
-
-
-
-
-
-
-
-
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-
-
-
-
-
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-
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-
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6
-
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-
-
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-
1
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
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641118
Kizer
Purification and properties of ...
Rattus norvegicus
Biochim. Biophys. Acta
350
193-200
1974
-
-
-
-
-
-
1
2
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1
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2
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1
-
-
2
1
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
2
-
-
1
-
-
-
-
1
-
2
1
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
641141
Cheng
Mouse ascites Sarcoma 180 deox ...
Mus musculus
Biochemistry
13
1179-1185
1974
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-
-
-
-
1
5
5
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-
1
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1
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-
1
1
1
7
-
-
-
1
-
-
-
-
-
3
-
-
-
-
-
-
-
-
1
-
5
3
5
-
-
-
-
-
-
-
1
-
1
1
1
7
-
-
-
1
-
-
-
-
-
-
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-
641142
Kit
Properties of mitochondrial th ...
Homo sapiens
Arch. Biochem. Biophys.
158
503-513
1973
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-
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3
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2
1
2
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-
1
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-
-
-
1
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
2
1
2
-
-
-
-
-
-
1
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
641143
Taylor
Properties of thymidine kinase ...
Homo sapiens
J. Biol. Chem.
247
1930-1935
1972
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-
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3
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2
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2
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1
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3
1
1
1
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-
-
1
-
2
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-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
2
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-
-
-
-
-
1
-
3
1
1
1
-
-
-
1
-
2
-
-
-
-
-
-
-
-
-
641149
Chello
Comparative properties of tryp ...
Rattus norvegicus, Trypanosoma brucei rhodesiense
Comp. Biochem. Physiol. B
43
543-562
1972
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4
2
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9
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2
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2
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2
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-
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-
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4
-
2
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9
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-
2
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-
2
-
-
-
-
-
-
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-
-
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641144
Rohde
The purification of thymidine ...
Escherichia coli
Hoppe-Seyler's Z. Physiol. Chem.
352
1507-1516
1971
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-
-
-
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10
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2
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-
1
-
2
1
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-
-
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-
1
-
-
-
-
-
-
-
-
-
10
-
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-
-
-
-
-
-
-
-
-
-
1
-
2
1
-
-
-
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1
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641145
Her
Mammalian deoxynucleoside kina ...
Bos taurus
J. Biol. Chem.
246
6152-6158
1971
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5
2
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1
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1
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1
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-
1
1
1
2
-
-
-
-
-
-
-
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-
1
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-
-
-
-
-
-
-
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5
1
2
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1
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-
1
-
1
1
1
2
-
-
-
-
-
-
-
-
-
-
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-
-
-
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641116
Okazaki
Deoxythymidine kinase of Esche ...
Escherichia coli
J. Biol. Chem.
239
269-274
1964
1
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-
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2
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1
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1
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1
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6
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1
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-
1
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2
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1
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1
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6
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-
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1
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641117
Okazaki
Deoxythymidine kinase of Esche ...
Escherichia coli
J. Biol. Chem.
239
275-284
1964
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2
1
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2
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1
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6
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
1
-
2
-
-
-
-
-
-
-
-
-
-
6
-
-
-
-
-
-
-
-
-
-
-
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-
-
-