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Literature summary for 2.7.1.21 extracted from

  • Wang, L.; Munch-Petersen, B.; Herrstrom Sjoberg, A.; Hellman, U.; Bergman, T.; Jornvall, H.; Eriksson, S.
    Human thymidine kinase 2: molecular cloning and characterisation of the enzyme activity with antiviral and cytostatic nucleoside substrates (1999), FEBS Lett., 443, 170-174.
    View publication on PubMed
Search for more literature for 2.7.1.21

Cloned(Commentary)

Cloned (Comment) Organism
-
 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
deoxcytidine poor inhibitor Homo sapiens
thymidine inhibition of deoxycytidine kinase activity Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information
-
 Homo sapiens
0.029
-
 difluorodeoxyuridine
-
 Homo sapiens
0.066
-
 difluorodeoxycytidine
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining

Organism

Organism UniProt Comment Textmining
Homo sapiens O00142
-
-

Purification (Commentary)

Purification (Comment) Organism
rLyTK1Val-106 and rLyTK1Met-106 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 2'-deoxycytidine
-
 Homo sapiens ADP + 2'-deoxycytidine 5'-phosphate
-
 ?
ATP + arabinosyl cytosine
-
 Homo sapiens ?
-
 ?
ATP + difluorodeoxycytidine
-
 Homo sapiens ?
-
 ?
ATP + difluorodeoxyuridine
-
 Homo sapiens ?
-
 ?
ATP + thymidine ATP can be substituted by CTP Homo sapiens ADP + dTMP
-
 ?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.006
-
 thymidine
-
 Homo sapiens
0.63
-
 deoxycytidine
-
 Homo sapiens