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Literature summary for 2.7.1.21 extracted from

  • Taylor, A.T.; Stafford, M.A.; Jones, O.W.
    Properties of thymidine kinase partially purified from human fetal and adult tissue (1972), J. Biol. Chem., 247, 1930-1935.
    View publication on PubMed
Search for more literature for 2.7.1.21

Inhibitors

Inhibitors Comment Organism Structure
dCTP 80% inhibition of adult enzyme at 1 mM, almost no inhibition of fetal enzyme Homo sapiens
dTMP
-
 Homo sapiens
dTTP
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Homo sapiens 5829
-
mitochondrion
-
 Homo sapiens 5739
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
partial Homo sapiens
rLyTK1Val-106 and rLyTK1Met-106 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
fetus
-
 Homo sapiens
-
liver
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
 Homo sapiens

Storage Stability

Storage Stability Organism
-20°C, 50% glycerol, relatively stable Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + thymidine ATP can be substituted by dATP Homo sapiens ADP + dTMP
-
 ?

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
45
-
 5 min, fetal liver: 50% loss of activity, adult liver: 10% loss of activity Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7 8.5 adult liver Homo sapiens
7 7.2 fetal liver Homo sapiens