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Literature summary for 2.7.1.21 extracted from
- Deoxythymidine kinase induced in HeLa TK- cells by Herpes simplex virus type I and type II. II. Purification and characterization (1976), J. Biol. Chem., 251, 2605-2610.
General Stability
| General Stability | Organism |
|---|---|
| ATP or thymidine stabilizes, type I more stable in the presence of MgATP2- than type II | Herpes simplex virus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| ammoniumsulfate | 50% inhibition at 200 mM | Herpes simplex virus |  |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasm | - |
Herpes simplex virus | 5737 | - |
| nucleus | - |
Herpes simplex virus | 5634 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Herpes simplex virus | - |
type 2 | - |
| Herpes simplex virus | - |
type 1 | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| HeLa TK- cells infected with virus | Herpes simplex virus |
Storage Stability
| Storage Stability | Organism |
|---|---|
| -70°C, 0.2 mM deoxythymidine, 3 mM dithiothreitol, 10% glycerol | Herpes simplex virus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + thymidine | - |
Herpes simplex virus | ADP + dTMP | - |
? | |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 27 | 43 | stable | Herpes simplex virus |
| 45 | - |
half-life 28 min, Herpes simplex virus type 2: half-life 120 min | Herpes simplex virus |
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