Literature summary for 2.7.1.209 extracted from

Huang, H.; Carter, M.S.; Vetting, M.W.; Al-Obaidi, N.; Patskovsky, Y.; Almo, S.C.; Gerlt, J.A.
A general strategy for the discovery of metabolic pathways: D-threitol, L-threitol, and erythritol utilization in Mycobacterium smegmatis (2015), J. Am. Chem. Soc., 137, 14570-14573.

Search for more literature for 2.7.1.209

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.003	-	L-erythrulose	pH and temperature not specified in the publication	Mycolicibacterium smegmatis
0.0106	-	D-erythrulose	pH and temperature not specified in the publication	Mycolicibacterium smegmatis
0.0378	-	dihydroxyacetone	pH and temperature not specified in the publication	Mycolicibacterium smegmatis

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + L-erythrulose	Mycolicibacterium smegmatis	the enzyme participates in the degradation of L-threitol	ADP + L-erythrulose 4-phosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Mycolicibacterium smegmatis	A0R758	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + D-erythrulose	catalytic efficiency is 4fold lower compared to L-erythrulose as substrate	Mycolicibacterium smegmatis	ADP + D-erythrulose 4-phosphate	-	?
ATP + dihydroxyacetone	catalytic efficiency is about 100fold lower compared to L-erythrulose as substrate	Mycolicibacterium smegmatis	?	-	?
ATP + L-erythrulose	-	Mycolicibacterium smegmatis	ADP + L-erythrulose 4-phosphate	-	?
ATP + L-erythrulose	the enzyme participates in the degradation of L-threitol	Mycolicibacterium smegmatis	ADP + L-erythrulose 4-phosphate	-	?

Synonyms

Synonyms	Comment	Organism
lerK	-	Mycolicibacterium smegmatis

Turnover Number [1/s]

Turnover Number Minimum [1/s]	Turnover Number Maximum [1/s]	Substrate	Comment	Organism	Structure
1.6	-	D-erythrulose	pH and temperature not specified in the publication	Mycolicibacterium smegmatis
1.79	-	L-erythrulose	pH and temperature not specified in the publication	Mycolicibacterium smegmatis
2.12	-	dihydroxyacetone	pH and temperature not specified in the publication	Mycolicibacterium smegmatis

General Information

General Information	Comment	Organism
metabolism	the enzyme participates in the degradation of L-threitol	Mycolicibacterium smegmatis

kcat/KM [mM/s]

kcat/KM Value [1/mMs^-1]	kcat/KM Value Maximum [1/mMs^-1]	Substrate	Comment	Organism	Structure
56.1	-	dihydroxyacetone	pH and temperature not specified in the publication	Mycolicibacterium smegmatis
150.9	-	D-erythrulose	pH and temperature not specified in the publication	Mycolicibacterium smegmatis
597	-	L-erythrulose	pH and temperature not specified in the publication	Mycolicibacterium smegmatis

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)