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Literature summary for 2.7.1.20 extracted from

  • Dong, L.; Shi, J.; Wang, J.; Liu, Y.
    Theoretical studies on the conformational change of adenosine kinase induced by inhibitors (2011), Int. J. Quantum Chem., 111, 3980-3990.
No PubMed abstract available
Search for more literature for 2.7.1.20

Inhibitors

Inhibitors Comment Organism Structure
(2R,3R,4R)-2-[5-phenyl-4-(phenylamino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl]tetrahydrofuran-3,4-diol
-
 Homo sapiens
5-benzyl-6-[[6-(morpholin-4-yl)pyridin-3-yl]ethynyl]pyrimidin-4-amine
-
 Homo sapiens
5-[4-(dimethylamino)phenyl]-6-{[6-(morpholin-4-yl)pyridin-3-yl]ethynyl}pyrimidin-4-amine
-
 Homo sapiens
6-[[6-(morpholin-4-yl)pyridin-3-yl]ethynyl]-5-(2-phenylethyl)pyrimidin-4-amine
-
 Homo sapiens
6-[[6-(morpholin-4-yl)pyridin-3-yl]ethynyl]-5-(3-phenylpropyl)pyrimidin-4-amine
-
 Homo sapiens
6-[[6-(morpholin-4-yl)pyridin-3-yl]ethynyl]-5-(4-phenylbutyl)pyrimidin-4-amine
-
 Homo sapiens
6-[[6-(morpholin-4-yl)pyridin-3-yl]ethynyl]pyrimidin-4-amine hydrate (1:1)
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P55263
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + adenosine
-
 Homo sapiens ADP + AMP
-
 ?

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0000025
-
 pH and temperature not specified in the publication Homo sapiens 6-[[6-(morpholin-4-yl)pyridin-3-yl]ethynyl]-5-(3-phenylpropyl)pyrimidin-4-amine
0.0000045
-
 pH and temperature not specified in the publication Homo sapiens 6-[[6-(morpholin-4-yl)pyridin-3-yl]ethynyl]-5-(2-phenylethyl)pyrimidin-4-amine
0.000038
-
 pH and temperature not specified in the publication Homo sapiens 6-[[6-(morpholin-4-yl)pyridin-3-yl]ethynyl]-5-(4-phenylbutyl)pyrimidin-4-amine
0.00004
-
 pH and temperature not specified in the publication Homo sapiens 5-benzyl-6-[[6-(morpholin-4-yl)pyridin-3-yl]ethynyl]pyrimidin-4-amine
0.00012
-
 pH and temperature not specified in the publication Homo sapiens 6-[[6-(morpholin-4-yl)pyridin-3-yl]ethynyl]pyrimidin-4-amine hydrate (1:1)