Inhibitors | Comment | Organism | Structure |
---|---|---|---|
6-benzylthioinosine | - |
Toxoplasma gondii | |
carbocyclic 6-(2,3,4-trimethylbenzylthio)inosine | - |
Toxoplasma gondii | |
carbocyclic 6-(2,4-dichlorobenzylthio)inosine | - |
Toxoplasma gondii | |
carbocyclic 6-(2-chloro-6-fluorobenzylthio)inosine | - |
Toxoplasma gondii | |
carbocyclic 6-(2-chlorobenzylthio)inosine | - |
Toxoplasma gondii | |
carbocyclic 6-(2-fluorobenzylthio)inosine | - |
Toxoplasma gondii | |
carbocyclic 6-(2-methylbenzylthio)inosine | - |
Toxoplasma gondii | |
carbocyclic 6-(3,4-dichlorobenzylthio)inosine | - |
Toxoplasma gondii | |
carbocyclic 6-(3-methylbenzylthio)inosine | - |
Toxoplasma gondii | |
carbocyclic 6-(3-nitrobenzylthio)inosine | - |
Toxoplasma gondii | |
carbocyclic 6-(3-trifluoromethylbenzylthio)inosine | - |
Toxoplasma gondii | |
carbocyclic 6-(4-bromobenzylthio)inosine | - |
Toxoplasma gondii | |
carbocyclic 6-(4-chlorobenzylthio)inosine | - |
Toxoplasma gondii | |
carbocyclic 6-(4-cyanobenzylthio)inosine | weakest inhibitor | Toxoplasma gondii | |
carbocyclic 6-(4-fluorobenzylthio)inosine | - |
Toxoplasma gondii | |
carbocyclic 6-(4-methoxybenzylthio)inosine | - |
Toxoplasma gondii | |
carbocyclic 6-(4-methoxycarbonylbenzylthio)inosine | - |
Toxoplasma gondii | |
carbocyclic 6-(4-methylbenzylthio)inosine | - |
Toxoplasma gondii | |
carbocyclic 6-(4-methylsulfonylbenzylthio)inosine | - |
Toxoplasma gondii | |
carbocyclic 6-(4-nitrobenzylthio)inosine | - |
Toxoplasma gondii | |
carbocyclic 6-(4-trifluoromethoxybenzylthio)inosine | - |
Toxoplasma gondii | |
carbocyclic 6-(p-methoxycarbonylbenzylthio)inosine | - |
Toxoplasma gondii | |
carbocyclic 6-benzylthioinosine | - |
Toxoplasma gondii | |
pyrimethamine | - |
Toxoplasma gondii | |
Sulfadiazine | - |
Toxoplasma gondii |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Toxoplasma gondii | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + adenosine | - |
Toxoplasma gondii | ADP + AMP | - |
? |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0119 | - |
in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2; 1 mM dithiothreitol, 25 mM NaF, at 37°C | Toxoplasma gondii | carbocyclic 6-(4-methylbenzylthio)inosine | |
0.0121 | - |
in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2; 1 mM dithiothreitol, 25 mM NaF, at 37°C | Toxoplasma gondii | carbocyclic 6-(4-methoxybenzylthio)inosine | |
0.0128 | - |
in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2; 1 mM dithiothreitol, 25 mM NaF, at 37°C | Toxoplasma gondii | carbocyclic 6-(p-methoxycarbonylbenzylthio)inosine | |
0.0136 | - |
in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2; 1 mM dithiothreitol, 25 mM NaF, at 37°C | Toxoplasma gondii | carbocyclic 6-(2-chloro-6-fluorobenzylthio)inosine | |
0.0144 | - |
in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2; 1 mM dithiothreitol, 25 mM NaF, at 37°C | Toxoplasma gondii | carbocyclic 6-(3,4-dichlorobenzylthio)inosine | |
0.0145 | - |
in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2; 1 mM dithiothreitol, 25 mM NaF, at 37°C | Toxoplasma gondii | carbocyclic 6-(4-chlorobenzylthio)inosine | |
0.0146 | - |
in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2; 1 mM dithiothreitol, 25 mM NaF, at 37°C | Toxoplasma gondii | carbocyclic 6-(4-methylsulfonylbenzylthio)inosine | |
0.0161 | - |
in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2; 1 mM dithiothreitol, 25 mM NaF, at 37°C | Toxoplasma gondii | pyrimethamine | |
0.0161 | - |
in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2; 1 mM dithiothreitol, 25 mM NaF, at 37°C | Toxoplasma gondii | carbocyclic 6-(2,3,4-trimethylbenzylthio)inosine | |
0.0183 | - |
in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2; 1 mM dithiothreitol, 25 mM NaF, at 37°C | Toxoplasma gondii | carbocyclic 6-(4-bromobenzylthio)inosine | |
0.0186 | - |
in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2; 1 mM dithiothreitol, 25 mM NaF, at 37°C | Toxoplasma gondii | carbocyclic 6-(2,4-dichlorobenzylthio)inosine | |
0.0191 | - |
in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2; 1 mM dithiothreitol, 25 mM NaF, at 37°C | Toxoplasma gondii | carbocyclic 6-benzylthioinosine | |
0.0191 | - |
in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2; 1 mM dithiothreitol, 25 mM NaF, at 37°C | Toxoplasma gondii | carbocyclic 6-(3-trifluoromethylbenzylthio)inosine | |
0.0197 | - |
in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2; 1 mM dithiothreitol, 25 mM NaF, at 37°C | Toxoplasma gondii | carbocyclic 6-(2-methylbenzylthio)inosine | |
0.0197 | - |
in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2; 1 mM dithiothreitol, 25 mM NaF, at 37°C | Toxoplasma gondii | carbocyclic 6-(3-nitrobenzylthio)inosine | |
0.02 | - |
in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2; 1 mM dithiothreitol, 25 mM NaF, at 37°C | Toxoplasma gondii | carbocyclic 6-(2-chlorobenzylthio)inosine | |
0.0204 | - |
in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2; 1 mM dithiothreitol, 25 mM NaF, at 37°C | Toxoplasma gondii | 6-benzylthioinosine | |
0.021 | - |
in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2; 1 mM dithiothreitol, 25 mM NaF, at 37°C | Toxoplasma gondii | carbocyclic 6-(4-trifluoromethoxybenzylthio)inosine | |
0.0232 | - |
in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2; 1 mM dithiothreitol, 25 mM NaF, at 37°C | Toxoplasma gondii | carbocyclic 6-(4-fluorobenzylthio)inosine | |
0.0238 | - |
in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2; 1 mM dithiothreitol, 25 mM NaF, at 37°C | Toxoplasma gondii | carbocyclic 6-(3-methylbenzylthio)inosine | |
0.0273 | - |
in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2; 1 mM dithiothreitol, 25 mM NaF, at 37°C | Toxoplasma gondii | Sulfadiazine | |
0.0389 | - |
in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2; 1 mM dithiothreitol, 25 mM NaF, at 37°C | Toxoplasma gondii | carbocyclic 6-(2-fluorobenzylthio)inosine | |
0.0428 | - |
in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2; 1 mM dithiothreitol, 25 mM NaF, at 37°C | Toxoplasma gondii | carbocyclic 6-(4-nitrobenzylthio)inosine | |
0.049 | - |
in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2; 1 mM dithiothreitol, 25 mM NaF, at 37°C | Toxoplasma gondii | carbocyclic 6-(4-cyanobenzylthio)inosine |