Activating Compound | Comment | Organism | Structure |
---|---|---|---|
phosphate | stimulates | Trypanosoma brucei |
Cloned (Comment) | Organism |
---|---|
expression in Escherichia coli | Trypanosoma brucei |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
adenosine | - |
Trypanosoma brucei |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.000041 | - |
adenosine | pH 7.6, 37°C | Trypanosoma brucei | |
0.013 | - |
cordycepin | pH 7.6, 37°C | Trypanosoma brucei | |
0.026 | - |
ATP | pH 7.6, 37°C | Trypanosoma brucei | |
0.082 | - |
GTP | pH 7.6, 37°C | Trypanosoma brucei | |
0.11 | - |
deoxyadenosine | pH 7.6, 37°C | Trypanosoma brucei | |
0.34 | - |
UTP | pH 7.6, 37°C | Trypanosoma brucei | |
0.54 | - |
fludarabine | pH 7.6, 37°C | Trypanosoma brucei | |
0.57 | - |
Inosine | pH 7.6, 37°C | Trypanosoma brucei | |
0.61 | - |
CTP | pH 7.6, 37°C | Trypanosoma brucei |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
MgCl2 | required | Trypanosoma brucei |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Trypanosoma brucei | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Trypanosoma brucei |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + adenosine | - |
Trypanosoma brucei | ADP + AMP | - |
? | |
ATP + cordycepin | - |
Trypanosoma brucei | ADP + cordycepin 5'-phosphate | - |
? | |
ATP + deoxyadenosine | - |
Trypanosoma brucei | ADP + deoxyadenosine 5'-phosphate | - |
? | |
ATP + fludarabine | - |
Trypanosoma brucei | ADP + fludarabine 5'-phosphate | - |
? | |
ATP + inosine | - |
Trypanosoma brucei | ADP + inosine 5'-phosphate | - |
? | |
CTP + adenosine | - |
Trypanosoma brucei | CDP + AMP | - |
? | |
GTP + adenosine | - |
Trypanosoma brucei | GDP + AMP | - |
? | |
UTP + adenosine | - |
Trypanosoma brucei | UDP + AMP | - |
? |
Synonyms | Comment | Organism |
---|---|---|
TbAK | - |
Trypanosoma brucei |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.11 | - |
fludarabine | pH 7.6, 37°C | Trypanosoma brucei | |
1.1 | - |
Inosine | pH 7.6, 37°C | Trypanosoma brucei | |
3.9 | - |
cordycepin | pH 7.6, 37°C | Trypanosoma brucei | |
4.2 | - |
deoxyadenosine | pH 7.6, 37°C | Trypanosoma brucei | |
7.3 | - |
ATP | pH 7.6, 37°C | Trypanosoma brucei | |
8.1 | - |
adenosine | pH 7.6, 37°C | Trypanosoma brucei | |
16 | - |
GTP | pH 7.6, 37°C | Trypanosoma brucei | |
18 | - |
UTP | pH 7.6, 37°C | Trypanosoma brucei | |
20 | - |
CTP | pH 7.6, 37°C | Trypanosoma brucei |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8 | - |
- |
Trypanosoma brucei |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
6 | 9.5 | pH 6.0: about 70% of maximal activity, pH 9.5: about 60% of maximal activity | Trypanosoma brucei |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.014 | - |
adenosine | pH 7.6, 37°C | Trypanosoma brucei |