Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.1.20 extracted from

  • Vodnala, M.; Fijolek, A.; Rofougaran, R.; Mosimann, M.; Maeser, P.; Hofer, A.
    Adenosine kinase mediates high affinity adenosine salvage in Trypanosoma brucei (2008), J. Biol. Chem., 283, 5380-5388.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
phosphate stimulates Trypanosoma brucei

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Trypanosoma brucei

Inhibitors

Inhibitors Comment Organism Structure
adenosine
-
Trypanosoma brucei

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.000041
-
adenosine pH 7.6, 37°C Trypanosoma brucei
0.013
-
cordycepin pH 7.6, 37°C Trypanosoma brucei
0.026
-
ATP pH 7.6, 37°C Trypanosoma brucei
0.082
-
GTP pH 7.6, 37°C Trypanosoma brucei
0.11
-
deoxyadenosine pH 7.6, 37°C Trypanosoma brucei
0.34
-
UTP pH 7.6, 37°C Trypanosoma brucei
0.54
-
fludarabine pH 7.6, 37°C Trypanosoma brucei
0.57
-
Inosine pH 7.6, 37°C Trypanosoma brucei
0.61
-
CTP pH 7.6, 37°C Trypanosoma brucei

Metals/Ions

Metals/Ions Comment Organism Structure
MgCl2 required Trypanosoma brucei

Organism

Organism UniProt Comment Textmining
Trypanosoma brucei
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Trypanosoma brucei

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + adenosine
-
Trypanosoma brucei ADP + AMP
-
?
ATP + cordycepin
-
Trypanosoma brucei ADP + cordycepin 5'-phosphate
-
?
ATP + deoxyadenosine
-
Trypanosoma brucei ADP + deoxyadenosine 5'-phosphate
-
?
ATP + fludarabine
-
Trypanosoma brucei ADP + fludarabine 5'-phosphate
-
?
ATP + inosine
-
Trypanosoma brucei ADP + inosine 5'-phosphate
-
?
CTP + adenosine
-
Trypanosoma brucei CDP + AMP
-
?
GTP + adenosine
-
Trypanosoma brucei GDP + AMP
-
?
UTP + adenosine
-
Trypanosoma brucei UDP + AMP
-
?

Synonyms

Synonyms Comment Organism
TbAK
-
Trypanosoma brucei

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.11
-
fludarabine pH 7.6, 37°C Trypanosoma brucei
1.1
-
Inosine pH 7.6, 37°C Trypanosoma brucei
3.9
-
cordycepin pH 7.6, 37°C Trypanosoma brucei
4.2
-
deoxyadenosine pH 7.6, 37°C Trypanosoma brucei
7.3
-
ATP pH 7.6, 37°C Trypanosoma brucei
8.1
-
adenosine pH 7.6, 37°C Trypanosoma brucei
16
-
GTP pH 7.6, 37°C Trypanosoma brucei
18
-
UTP pH 7.6, 37°C Trypanosoma brucei
20
-
CTP pH 7.6, 37°C Trypanosoma brucei

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
-
Trypanosoma brucei

pH Range

pH Minimum pH Maximum Comment Organism
6 9.5 pH 6.0: about 70% of maximal activity, pH 9.5: about 60% of maximal activity Trypanosoma brucei

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.014
-
adenosine pH 7.6, 37°C Trypanosoma brucei