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Literature summary for 2.7.1.20 extracted from

  • Bookser, B.C.; Matelich, M.C.; Ollis, K.; Ugarkar, B.G.
    Adenosine kinase inhibitors. 4. 6,8-disubstituted purine nucleoside derivatives. Synthesis, conformation, and enzyme inhibition (2005), J. Med. Chem., 48, 3389-3399.
    View publication on PubMed
Search for more literature for 2.7.1.20

Inhibitors

Inhibitors Comment Organism Structure
6,8-bis(anilin-N-yl)-9-(beta-D-ribofuranosyl)purine IC50: 90 nM Homo sapiens
6,8-bis(indolin-N-yl)-9-(beta-D-ribofuranosyl)purine IC50: 2000 nM Homo sapiens
6-indolin-N-yl-8-chloro-9-(beta-D-ribofuranosyl)purine IC50: 480 nM Homo sapiens
6-indolin-N-yl-8-iodo-9-(beta-D-ribofuranosyl)purine IC50: 1000 nM Homo sapiens
6-indolin-N-yl-8-methylthio-9-(beta-D-ribofuranosyl)-purine IC50: 150 nM Homo sapiens
6-indolin-N-yl-8-vinyl-9-(beta-D-ribofuranosyl)purine IC50: 60 nM Homo sapiens
8-acetylenyl-6-indolin-N-yl-9-(beta-D-ribofuranosyl)-purine IC50: 1000 nM Homo sapiens
8-anilin-N-yl-6-indolin-N-yl-9-(5-deoxy-beta-D-ribofuranosyl)purine IC50: 200 nM Homo sapiens
8-anilin-N-yl-6-indolin-N-yl-9-(beta-D-ribofuranosyl)-purine IC50: 19 nM Homo sapiens
8-ethyl-6-indolin-N-yl-9-(beta-D-ribofuranosyl)purine IC50: 230 nM Homo sapiens
8-furan-2-yl-6-indolin-N-yl-9-(beta-D-ribofuranosyl)-purine IC50: 2900 mM Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 recombinant
-

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000019
-
 IC50: 19 nM Homo sapiens 8-anilin-N-yl-6-indolin-N-yl-9-(beta-D-ribofuranosyl)-purine
0.00006
-
 IC50: 60 nM Homo sapiens 6-indolin-N-yl-8-vinyl-9-(beta-D-ribofuranosyl)purine
0.00009
-
 IC50: 90 nM Homo sapiens 6,8-bis(anilin-N-yl)-9-(beta-D-ribofuranosyl)purine
0.00015
-
 IC50: 150 nM Homo sapiens 6-indolin-N-yl-8-methylthio-9-(beta-D-ribofuranosyl)-purine
0.0002
-
 IC50: 200 nM Homo sapiens 8-anilin-N-yl-6-indolin-N-yl-9-(5-deoxy-beta-D-ribofuranosyl)purine
0.00023
-
 IC50: 230 nM Homo sapiens 8-ethyl-6-indolin-N-yl-9-(beta-D-ribofuranosyl)purine
0.00048
-
 IC50: 480 nM Homo sapiens 6-indolin-N-yl-8-chloro-9-(beta-D-ribofuranosyl)purine
0.001
-
 IC50: 1000 nM Homo sapiens 6-indolin-N-yl-8-iodo-9-(beta-D-ribofuranosyl)purine
0.001
-
 IC50: 1000 nM Homo sapiens 8-acetylenyl-6-indolin-N-yl-9-(beta-D-ribofuranosyl)-purine
0.002
-
 IC50: 2000 nM Homo sapiens 6,8-bis(indolin-N-yl)-9-(beta-D-ribofuranosyl)purine
2900
-
 IC50: 2900 mM Homo sapiens 8-furan-2-yl-6-indolin-N-yl-9-(beta-D-ribofuranosyl)-purine