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Literature summary for 2.7.1.20 extracted from

  • Reddy, M.C.; Palaninathan, S.K.; Shetty, N.D.; Owen, J.L.; Watson, M.D.; Sacchettini, J.C.
    High resolution crystal structures of Mycobacterium tuberculosis adenosine kinase: Insights into the mechanism and specificity of this novel prokaryotic enzyme (2007), J. Biol. Chem., 282, 27334-27342.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
-
Mycobacterium tuberculosis

Crystallization (Commentary)

Crystallization (Comment) Organism
crystals are obtained by either hanging drop or sitting drop vapor diffusion methods. Crystal structure of of ADK unliganded as well as ligand (adenosine) bound at 1.5- and 1.9-A resolution, respectively. The structure of the binary complexes with the inhibitor 2-fluoroadenosine bound and with the adenosine 5'-(beta,gamma-methylene)triphosphate (non-hydrolyzable ATP analog) bound are solved at 1.9-A resolution Mycobacterium tuberculosis
hanging drop or sitting drop vapor diffusion methods. Crystal structure of unliganded enzyme as well as adenosine bound enzyme at 1.5 A and 1.9 A resolution, respectively. The structure of the binary complexes with the inhibitor 2-fluoroadenosine bound and with the adenosine 5'-(beta,gamma-methylene)triphosphate bound are solved at 1.9 A resolution Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + adenosine Mycobacterium tuberculosis
-
ADP + AMP
-
?
ATP + adenosine Mycobacterium tuberculosis H37Rv
-
ADP + AMP
-
?

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis
-
-
-
Mycobacterium tuberculosis P9WID5
-
-
Mycobacterium tuberculosis H37Rv P9WID5
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Mycobacterium tuberculosis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + adenosine
-
Mycobacterium tuberculosis ADP + AMP
-
?
ATP + adenosine
-
Mycobacterium tuberculosis H37Rv ADP + AMP
-
?

Synonyms

Synonyms Comment Organism
ADK
-
Mycobacterium tuberculosis