Any feedback?
Literature summary for 2.7.1.20 extracted from
- Myocardial adenosine kinase: activity and localization determined with rapid, radiometric assay (1973), Biochim. Biophys. Acta, 320, 388-396.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| coformycin | - |
Rattus norvegicus |  |
| Mg2+ | - |
Oryctolagus cuniculus | |
| Mg2+ | strong inhibition above 1 mM | Rattus norvegicus | |
| MgATP2- | above 1 mM | Rattus norvegicus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0058 | 0.006 | adenosine | - |
Cavia porcellus | |
| 0.0058 | 0.006 | adenosine | - |
Oryctolagus cuniculus | |
| 0.0058 | 0.006 | adenosine | - |
Felis catus | |
| 0.0058 | 0.006 | adenosine | pH 5.6, 25ºC | Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Cavia porcellus | 5829 | - |
| cytosol | - |
Rattus norvegicus | 5829 | - |
| cytosol | - |
Oryctolagus cuniculus | 5829 | - |
| cytosol | - |
Felis catus | 5829 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | requirement | Cavia porcellus | |
| Mg2+ | requirement | Rattus norvegicus | |
| Mg2+ | requirement | Oryctolagus cuniculus | |
| Mg2+ | requirement | Felis catus | |
| Mg2+ | optimal at Mg: ATP ratio 1 | Cavia porcellus | |
| Mg2+ | optimal at Mg: ATP ratio 1 | Rattus norvegicus | |
| Mg2+ | optimal at Mg: ATP ratio 1 | Oryctolagus cuniculus | |
| Mg2+ | optimal at Mg: ATP ratio 1 | Felis catus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Cavia porcellus | - |
guinea pig, male | - |
| Felis catus | - |
female | - |
| Oryctolagus cuniculus | - |
rabbit | - |
| Oryctolagus cuniculus | - |
female | - |
| Rattus norvegicus | - |
rat | - |
| Rattus norvegicus | - |
male, Wistar strain | - |
| Rattus norvegicus Wistar | - |
male, Wistar strain | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| heart | myocard | Cavia porcellus | - |
| heart | myocard | Rattus norvegicus | - |
| heart | myocard | Oryctolagus cuniculus | - |
| heart | myocard | Felis catus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
0.23 U/g protein | Felis catus |
| additional information | - |
0.48 U/g protein | Rattus norvegicus |
| additional information | - |
0.19 U/g protein | Oryctolagus cuniculus |
| additional information | - |
0.46 U/g protein | Cavia porcellus |
Storage Stability
| Storage Stability | Organism |
|---|---|
| -15ºC, stable for few weeks | Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + adenosine | - |
Cavia porcellus | ADP + AMP | - |
? | |
| ATP + adenosine | - |
Rattus norvegicus | ADP + AMP | - |
? | |
| ATP + adenosine | - |
Oryctolagus cuniculus | ADP + AMP | - |
? | |
| ATP + adenosine | - |
Felis catus | ADP + AMP | - |
? | |
| ATP + adenosine | - |
Rattus norvegicus Wistar | ADP + AMP | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 41 | 45 | - |
Rattus norvegicus |
Temperature Range [°C]
| Temperature Minimum [°C] | Temperature Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 35 | 50 | about half-maximal activity at 35°C, about 90% of maximal activity at 50°C | Rattus norvegicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 5.4 | 5.6 | - |
Rattus norvegicus |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
