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Literature summary for 2.7.1.2 extracted from

  • Buechner, G.S.; Millington, M.E.; Perry, K.; DAntonio, E.L.
    The crystal structure of glucokinase from Leishmania braziliensis (2019), Mol. Biochem. Parasitol., 227, 47-52 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.1.2

Cloned(Commentary)

Cloned (Comment) Organism
-
 Leishmania braziliensis

Crystallization (Commentary)

Crystallization (Comment) Organism
1.85 A resolution X-ray crystal structure of the apo form Leishmania braziliensis

Inhibitors

Inhibitors Comment Organism Structure
hydroxyphenyloxopropyl glucosamine competitive inhibition Leishmania braziliensis

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.338
-
 ATP pH and temperature not specified in the publication Leishmania braziliensis
6.61
-
 D-glucose pH and temperature not specified in the publication Leishmania braziliensis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + D-glucose Leishmania braziliensis
-
 ADP + D-glucose 6-phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Leishmania braziliensis A4HPA0
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + D-glucose
-
 Leishmania braziliensis ADP + D-glucose 6-phosphate
-
 ?

Subunits

Subunits Comment Organism
homodimer each subunit (both in open conformations) includes the typical small and large domains Leishmania braziliensis

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0569
-
 hydroxyphenyloxopropyl glucosamine pH and temperature not specified in the publication Leishmania braziliensis

General Information

General Information Comment Organism
drug target glucokinase from pathogenic protozoa of the genus Leishmania is a potential drug target for the chemotherapeutic treatment against leishmaniasis because this enzyme is located at a nodal point between two critically important metabolic pathways, glycolysis and the pentose phosphate pathway Leishmania braziliensis
metabolism the enzyme is located at a nodal point between two critically important metabolic pathways, glycolysis and the pentose phosphate pathway Leishmania braziliensis