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Literature summary for 2.7.1.199 extracted from
- The glucose-specific carrier of the Escherichia coli phosphotransferase system (2002), Eur. J. Biochem., 269, 4969-4980.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 2',3'-epoxypropyl beta-D-glucopyranoside | - |
Escherichia coli |  |
| beta-D-glucopyranosyl isothiocyanate | - |
Escherichia coli | |
| beta-D-glucopyranosyl phenyl isothiocyanate | - |
Escherichia coli | |
| chloroacetyl beta-D-glucopyranoside | - |
Escherichia coli | |
| methyl 6,7-anhydro-DL-glycero-alpha-D-gluco-heptopyranoside | - |
Escherichia coli | |
| methyl 6-deoxy-6-isothiocyanate-alpha-D-glucopyranoside | - |
Escherichia coli | |
| methyl alpha-D-glucopyranoside | - |
Escherichia coli | |
| methyl alpha-D-mannopyranoside | - |
Escherichia coli | |
| additional information | not inhibited by beta-D-glucopyranosyl isothiocyanate, methyl 6-O-chloroacetyl-alpha-D-glucopyranoside, and (6E)-6,7-dideoxy-alpha-D-gluco-oct-6-enopyranosiduronic acid | Escherichia coli |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.028 | - |
2',3'-epoxypropyl beta-D-glucopyranoside | at pH 7.5 and 30°C | Escherichia coli | |
| 0.06 | - |
D-glucose[side 1] | at pH 7.5 and 30°C | Escherichia coli | |
| 0.7 | - |
chloroacetyl beta-D-glucopyranoside | at pH 7.5 and 30°C | Escherichia coli | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | - |
Escherichia coli | 16020 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| [protein]-Npi-phospho-L-histidine + D-glucose[side 1] | Escherichia coli | - |
[protein]-L-histidine + D-glucose 6-phosphate[side 2] | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| [protein]-Npi-phospho-L-histidine + 2',3'-epoxypropyl beta-D-glucopyranoside | pseudosubstrate | Escherichia coli | ? | - |
? | |
| [protein]-Npi-phospho-L-histidine + chloroacetyl beta-D-glucopyranoside | pseudosubstrate | Escherichia coli | ? | - |
? | |
| [protein]-Npi-phospho-L-histidine + D-glucose[side 1] | - |
Escherichia coli | [protein]-L-histidine + D-glucose 6-phosphate[side 2] | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| EIIGlc | - |
Escherichia coli |
| glucose transporter | - |
Escherichia coli |
| glucose-specific carrier | - |
Escherichia coli |
| IIAGlc | - |
Escherichia coli |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.00007 | - |
at pH 7.5 and 30°C | Escherichia coli | methyl 6,7-anhydro-DL-glycero-alpha-D-gluco-heptopyranoside | |
| 0.0008 | - |
at pH 7.5 and 30°C | Escherichia coli | methyl alpha-D-glucopyranoside | |
| 0.0008 | - |
at pH 7.5 and 30°C | Escherichia coli | methyl alpha-D-mannopyranoside | |
| 0.0009 | - |
at pH 7.5 and 30°C | Escherichia coli | methyl 6-deoxy-6-isothiocyanate-alpha-D-glucopyranoside | |
| 0.001 | - |
at pH 7.5 and 30°C | Escherichia coli | 2',3'-epoxypropyl beta-D-glucopyranoside | |
| 0.0013 | - |
at pH 7.5 and 30°C | Escherichia coli | chloroacetyl beta-D-glucopyranoside | |
| 0.0024 | - |
at pH 7.5 and 30°C | Escherichia coli | beta-D-glucopyranosyl phenyl isothiocyanate | |
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Release 2023.1 (January 2023)
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