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Literature summary for 2.7.1.173 extracted from

  • Fletcher, R.S.; Lavery, G.G.
    The emergence of the nicotinamide riboside kinases in the regulation of NAD+ metabolism (2018), J. Mol. Endocrinol., 61, R107-R121 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.1.173

Cloned(Commentary)

Cloned (Comment) Organism
gene NMRK1 Homo sapiens
gene NMRK2 Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.051
-
 beta-D-ribosylnicotinate with ATP, pH and temperature not specified in the publication Homo sapiens
0.063
-
 beta-D-ribosylnicotinate with ATP, pH and temperature not specified in the publication Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + beta-D-ribosylnicotinate Homo sapiens
-
 ADP + nicotinate beta-D-ribonucleotide
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9NPI5
-
-
Homo sapiens Q9NWW6
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + beta-D-ribosylnicotinate
-
 Homo sapiens ADP + nicotinate beta-D-ribonucleotide
-
 ?

Synonyms

Synonyms Comment Organism
More see also EC 2.7.1.22 Homo sapiens
nicotinamide riboside kinase 1
-
 Homo sapiens
nicotinamide riboside kinase 2
-
 Homo sapiens
NMRK1
-
 Homo sapiens
NMRK2
-
 Homo sapiens
NRK1
-
 Homo sapiens
Nrk2
-
 Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.21
-
 beta-D-ribosylnicotinate with ATP, pH and temperature not specified in the publication Homo sapiens
0.34
-
 beta-D-ribosylnicotinate with ATP, pH and temperature not specified in the publication Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens Nmrk2 mRNA expression is substantially induced (over 80fold) in models of lethal cardiomyopathy up

General Information

General Information Comment Organism
metabolism the enzyme is involved in the NAD+ biosynthesis pathway. In the initial step of the pathway, NRK activity catalyses the phosphorylation of nicotinamide riboside (NR) to nicotinamide mononucleotide (NMN), see for EC 2.7.1.22. Importance of different salvage pathways involved in metabolising the vitamin B3 class of NAD+ precursor molecules, with a particular focus on the nicotinamide riboside kinase pathway at both a tissue-specific and systemic level, regulation of the NRK enzymes, overview. Alternatively, NRK activity can phosphorylate nicotinic acid riboside (NaR) to nicotinic acid mononucleotide (NaMN) Homo sapiens
additional information proposed NRK expression in disease and potential therapeutic interventions Homo sapiens
physiological function NRK2 appears to play a redundant role in NAD+ biosynthesis along with NRK1, at least in unchallenged models, its highly regulated expression particularly in times of stress suggest it may have role beyond NAD+ metabolism Homo sapiens

kcat/KM [mM/s]

kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
4.12
-
 beta-D-ribosylnicotinate with ATP, pH and temperature not specified in the publication Homo sapiens
5.4
-
 beta-D-ribosylnicotinate with ATP, pH and temperature not specified in the publication Homo sapiens