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Literature summary for 2.7.1.171 extracted from

  • Sartore, G.; Ragazzi, E.; Burlina, S.; Paleari, R.; Chilelli, N.C.; Mosca, A.; Avemaria, F.; Lapolla, A.
    Role of fructosamine-3-kinase in protecting against the onset of microvascular and macrovascular complications in patients with T2DM (2020), BMJ Open Diabetes Res. Care, 8, e001256 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.1.171

Cloned(Commentary)

Cloned (Comment) Organism
gene FN3K, DNA and amino acid sequence analysis, genotyping Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information allelic variants of FN3K polymorphisms revealed 13 distinct genotypic variants in a cohort of patients with type 2 diabetes mellitus (T2DM), detection of three polymorphisms associated with the enzymatic activity (rs3859206 and rs2256339 in the promoter region and rs1056534 in exon 6). The FN3K genotype presenting GG at position -385, TT at position -232, and CC at c.900 A, is associated with less severe microangiopathic and macroangiopathic complications as a whole, compared to all other genotypes Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
intracellular
-
 Homo sapiens 5622
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + [protein]-N6-D-fructosyl-L-lysine Homo sapiens
-
 ADP + [protein]-N6-(3-O-phospho-D-fructosyl)-L-lysine
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9H479
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + [protein]-N6-D-fructosyl-L-lysine
-
 Homo sapiens ADP + [protein]-N6-(3-O-phospho-D-fructosyl)-L-lysine
-
 ?

Synonyms

Synonyms Comment Organism
FN3K
-
 Homo sapiens
fructosamine-3-kinase
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction polymorphisms of the FN3K gene are associated with variations in HbA1c levels and with the onset of type 2 diabetes mellitus (T2DM) and pathogenic mechanisms related to its complications, role of FN3K polymorphisms in the development of microvascular and macrovascular complications of diabetes, overview. The FN3K genotype presenting GG at position -385, TT at position -232, and CC at c.900 A, is associated with less severe microangiopathic and macroangiopathic complications as a whole, compared to all other genotypes Homo sapiens
physiological function fructosamine-3-kinase (FN3K) is involved in deglycation, active in removing ketoamines, and preventing advanced glycation end product production. Enzyme FN3K is capable of counteracting the effect of hyperglycemia by intervening in protein glycation. The FN3K genetic variability is linked to the enzyme's enzymatic activity and glycated hemoglobin (HbA1c) levels Homo sapiens