Protein Variants | Comment | Organism |
---|---|---|
additional information | diabetic subjects with the CC variant of SNP rs1056534 (G900C), which is associated with a higher FN3K activity, have lower HbA1c levels compared with other genotypes | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [protein]-N6-D-fructosyl-L-lysine | Homo sapiens | - |
ADP + [protein]-N6-(O3-phosphono-D-fructosyl)-L-lysine | - |
? | |
ATP + [protein]-N6-D-fructosyl-L-lysine | Mus musculus | mice deficient in FN3K accumulate protein-bound fructosamines and free fructoselysine, indicating that the deglycation mechanism initiated by FN3K is operative in vivo | ADP + [protein]-N6-(O3-phosphono-D-fructosyl)-L-lysine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
erythrocyte | the human erythrocyte FN3K activity, which is stable with time in a single individual, is highly variable from person to person. This variability, which is linked to single nucleotide polymorphisms that are present in the FN3K gene, affects the glycation level of at least one specific site in haemoglobin | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [protein]-N6-D-fructosyl-L-lysine | - |
Homo sapiens | ADP + [protein]-N6-(O3-phosphono-D-fructosyl)-L-lysine | - |
? | |
ATP + [protein]-N6-D-fructosyl-L-lysine | mice deficient in FN3K accumulate protein-bound fructosamines and free fructoselysine, indicating that the deglycation mechanism initiated by FN3K is operative in vivo | Mus musculus | ADP + [protein]-N6-(O3-phosphono-D-fructosyl)-L-lysine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
FN3K | - |
Homo sapiens |
fructose-3-kinase | - |
Mus musculus |
fructose-3-kinase | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | no regulation of the expression of fructose-3-kinase is observed in human fibroblasts treated with conditions mimicking the hormonal and biochemical profile of the diabetic state | additional information |
General Information | Comment | Organism |
---|---|---|
malfunction | mice deficient in FN3K accumulate protein-bound fructosamines and free fructoselysine, indicating that the deglycation mechanism initiated by FN3K is operative in vivo | Mus musculus |