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Literature summary for 2.7.1.171 extracted from

  • van Schaftingen, E.; Collard, F.; Wiame, E.; Veiga-da-Cunha, M.
    Enzymatic repair of Amadori products (2012), Amino Acids, 42, 1143-1150.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
additional information diabetic subjects with the CC variant of SNP rs1056534 (G900C), which is associated with a higher FN3K activity, have lower HbA1c levels compared with other genotypes Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + [protein]-N6-D-fructosyl-L-lysine Homo sapiens
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ADP + [protein]-N6-(O3-phosphono-D-fructosyl)-L-lysine
-
?
ATP + [protein]-N6-D-fructosyl-L-lysine Mus musculus mice deficient in FN3K accumulate protein-bound fructosamines and free fructoselysine, indicating that the deglycation mechanism initiated by FN3K is operative in vivo ADP + [protein]-N6-(O3-phosphono-D-fructosyl)-L-lysine
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?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
erythrocyte the human erythrocyte FN3K activity, which is stable with time in a single individual, is highly variable from person to person. This variability, which is linked to single nucleotide polymorphisms that are present in the FN3K gene, affects the glycation level of at least one specific site in haemoglobin Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + [protein]-N6-D-fructosyl-L-lysine
-
Homo sapiens ADP + [protein]-N6-(O3-phosphono-D-fructosyl)-L-lysine
-
?
ATP + [protein]-N6-D-fructosyl-L-lysine mice deficient in FN3K accumulate protein-bound fructosamines and free fructoselysine, indicating that the deglycation mechanism initiated by FN3K is operative in vivo Mus musculus ADP + [protein]-N6-(O3-phosphono-D-fructosyl)-L-lysine
-
?

Synonyms

Synonyms Comment Organism
FN3K
-
Homo sapiens
fructose-3-kinase
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Mus musculus
fructose-3-kinase
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Homo sapiens

Expression

Organism Comment Expression
Homo sapiens no regulation of the expression of fructose-3-kinase is observed in human fibroblasts treated with conditions mimicking the hormonal and biochemical profile of the diabetic state additional information

General Information

General Information Comment Organism
malfunction mice deficient in FN3K accumulate protein-bound fructosamines and free fructoselysine, indicating that the deglycation mechanism initiated by FN3K is operative in vivo Mus musculus