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Literature summary for 2.7.1.166 extracted from

  • Harper, M.; Cox, A.D.; St Michael, F.; Ford, M.; Wilkie, I.W.; Adler, B.; Boyce, J.D.
    Natural selection in the chicken host identifies 3-deoxy-D-manno-octulosonic acid kinase residues essential for phosphorylation of Pasteurella multocida lipopolysaccharide (2010), Infect. Immun., 78, 3669-3677.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
A112V spontaneous KdkA mutant strain isolated from birds inoculated with high doses of a heptosyltransferase hptA mutant. The birds developed fowl cholera and the Pasteurella multocida isolates recovered from diseased birds no longer express truncated lipopolysaccharide. Mutation results in low level of enzymic acitivity Pasteurella multocida
D193N spontaneous KdkA mutant strain isolated from birds inoculated with high doses of a heptosyltransferase hptA mutant. The birds developed fowl cholera and the Pasteurella multocida isolates recovered from diseased birds no longer express truncated lipopolysaccharide. Mutation leads to complete loss of enzymic acitivity Pasteurella multocida
H168Y spontaneous KdkA mutant strain isolated from birds inoculated with high doses of a heptosyltransferase hptA mutant. The birds developed fowl cholera and the Pasteurella multocida isolates recovered from diseased birds no longer express truncated lipopolysaccharide. Residue is critical for Kdo kinase function and therefore glycoform A lipopolysaccharide assembly Pasteurella multocida
R123P spontaneous KdkA mutant strain isolated from birds inoculated with high doses of a heptosyltransferase hptA mutant. The birds developed fowl cholera and the Pasteurella multocida isolates recovered from diseased birds no longer express truncated lipopolysaccharide. Mutation is likely to have a significant impact on the secondary structure and probably affects the hinge action of the linker region Pasteurella multocida

Organism

Organism UniProt Comment Textmining
Pasteurella multocida D9MNH9
-
-

Synonyms

Synonyms Comment Organism
KdkA
-
Pasteurella multocida
Kdo kinase
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Pasteurella multocida