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Literature summary for 2.7.1.160 extracted from

  • Lackey, J.G.; Ron, D.; Damha, M.J.; Harding, H.P.
    Toward the discovery of new antifungal agents: the design and validation of a novel 2P-RNA probe and high throughput screening assay against 2-phosphotransferase Tpt1p (2008), Nucleic Acids Symp. Ser., 52, 475-476.
    View publication on PubMed
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2'-phospho-(ligated tRNA) + NAD+ yeasts enzyme catalyzes final step in tRNA splicing mature tRNA + ADP-ribose 1'',2''-phosphate + nicotinamide + H2O
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 ?

Organism

Organism UniProt Comment Textmining
yeasts
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2'-phospho-(ligated tRNA) + NAD+ enzyme catalyzes final step in tRNA splicing yeasts mature tRNA + ADP-ribose 1'',2''-phosphate + nicotinamide + H2O
-
 ?
additional information synthesis of 5'-Lv-2'-DMT-3'-phosphoramidite-G monomer containing an internal 2-phosphate for incorporation in synthetic RNA in order to construct a fluorescent oligoribonucleotide probe for a high throughput screening assay against yeast Tpt1p. yeasts ?
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 ?

Synonyms

Synonyms Comment Organism
2'-phosphotransferase
-
 yeasts
Tpt1p
-
 yeasts

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 yeasts