BRENDA - Enzyme Database show
show all sequences of 2.7.1.157

N-acetylgalactosamine kinase: a naturally promiscuous small molecule kinase

Kristiansson, H.; Timson, D.J.; Appl. Biochem. Biotechnol. 166, 57-63 (2012)

Data extracted from this reference:

Cloned(Commentary)
Commentary
Organism
expression in Escherichia coli
Homo sapiens
Engineering
Amino acid exchange
Commentary
Organism
F444A
mutation in residue equivalent to residue Tyr379 of galactokinase, whose alteration dramatically enhances the substrate range of this enzyme. Mutation does not result in large changes to the specificity of the enzyme
Homo sapiens
F444C
mutation in residue equivalent to residue Tyr379 of galactokinase, whose alteration dramatically enhances the substrate range of this enzyme. Mutation does not result in large changes to the specificity of the enzyme but increases turnover rate with N-acetylgalactosamine
Homo sapiens
F444H
mutation in residue equivalent to residue Tyr379 of galactokinase, whose alteration dramatically enhances the substrate range of this enzyme. Mutation does not result in large changes to the specificity of the enzyme
Homo sapiens
F444K
mutation in residue equivalent to residue Tyr379 of galactokinase, whose alteration dramatically enhances the substrate range of this enzyme. Mutation does not result in large changes to the specificity of the enzyme
Homo sapiens
F444R
mutation in residue equivalent to residue Tyr379 of galactokinase, whose alteration dramatically enhances the substrate range of this enzyme. Mutation does not result in large changes to the specificity of the enzyme
Homo sapiens
F444S
mutation in residue equivalent to residue Tyr379 of galactokinase, whose alteration dramatically enhances the substrate range of this enzyme. Mutation does not result in large changes to the specificity of the enzyme but increases turnover rate with N-acetylgalactosamine
Homo sapiens
F444W
mutation in residue equivalent to residue Tyr379 of galactokinase, whose alteration dramatically enhances the substrate range of this enzyme. Mutation does not result in large changes to the specificity of the enzyme
Homo sapiens
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.006
-
ATP
mutant F444A, 37°C, pH 7.5, cosubstrate N-acetyl-alpha-D-galactosamine
Homo sapiens
0.009
-
ATP
mutant F444R, 37°C, pH 7.5, cosubstrate N-acetyl-alpha-D-galactosamine; wild-type, 37°C, pH 7.5, cosubstrate N-acetyl-alpha-D-glucosamine
Homo sapiens
0.011
-
ATP
mutant F444H, 37°C, pH 7.5, cosubstrate N-acetyl-alpha-D-galactosamine
Homo sapiens
0.013
-
ATP
mutant F444H, 37°C, pH 7.5, cosubstrate N-acetyl-alpha-D-glucosamine; mutant F444S, 37°C, pH 7.5, cosubstrate N-acetyl-alpha-D-glucosamine
Homo sapiens
0.015
-
ATP
mutant F444K, 37°C, pH 7.5, cosubstrate N-acetyl-alpha-D-galactosamine; mutant F444K, 37°C, pH 7.5, cosubstrate N-acetyl-alpha-D-glucosamine; mutant F444R, 37°C, pH 7.5, cosubstrate N-acetyl-alpha-D-glucosamine
Homo sapiens
0.017
-
ATP
mutant F444C, 37°C, pH 7.5, cosubstrate N-acetyl-alpha-D-mannosamine; mutant F444H, 37°C, pH 7.5, cosubstrate N-acetyl-alpha-D-mannosamine
Homo sapiens
0.018
-
ATP
mutant F444C, 37°C, pH 7.5, cosubstrate N-acetyl-alpha-D-glucosamine; wild-type, 37°C, pH 7.5, cosubstrate N-acetyl-alpha-D-galactosamine
Homo sapiens
0.019
-
ATP
mutant F444S, 37°C, pH 7.5, cosubstrate N-acetyl-alpha-D-galactosamine
Homo sapiens
0.024
-
ATP
mutant F444R, 37°C, pH 7.5, cosubstrate N-acetyl-alpha-D-mannosamine; mutant F444W, 37°C, pH 7.5, cosubstrate N-acetyl-alpha-D-galactosamine
Homo sapiens
0.025
-
ATP
mutant F444A, 37°C, pH 7.5, cosubstrate N-acetyl-alpha-D-glucosamine
Homo sapiens
0.027
-
ATP
mutant F444C, 37°C, pH 7.5, cosubstrate N-acetyl-alpha-D-galactosamine
Homo sapiens
0.028
-
ATP
mutant F444K, 37°C, pH 7.5, cosubstrate N-acetyl-alpha-D-mannosamine
Homo sapiens
0.032
-
ATP
wild-type, 37°C, pH 7.5, cosubstrate N-acetyl-alpha-D-mannosamine
Homo sapiens
0.039
-
ATP
mutant F444A, 37°C, pH 7.5, cosubstrate N-acetyl-alpha-D-mannosamine
Homo sapiens
0.051
-
N-acetyl-alpha-D-glucosamine
wild-type, 37°C, pH 7.5
Homo sapiens
0.12
-
N-acetyl-alpha-D-glucosamine
mutant F444K, 37°C, pH 7.5; mutant F444S, 37°C, pH 7.5
Homo sapiens
0.13
-
ATP
mutant F444S, 37°C, pH 7.5, cosubstrate N-acetyl-alpha-D-mannosamine
Homo sapiens
0.17
-
N-acetyl-alpha-D-galactosamine
mutant F444R, 37°C, pH 7.5
Homo sapiens
0.22
-
N-acetyl-alpha-D-glucosamine
mutant F444H, 37°C, pH 7.5
Homo sapiens
0.24
-
N-acetyl-alpha-D-galactosamine
mutant F444A, 37°C, pH 7.5
Homo sapiens
0.25
-
N-acetyl-alpha-D-mannosamine
mutant F444H, 37°C, pH 7.5
Homo sapiens
0.27
-
N-acetyl-alpha-D-galactosamine
mutant F444H, 37°C, pH 7.5
Homo sapiens
0.28
-
N-acetyl-alpha-D-glucosamine
mutant F444R, 37°C, pH 7.5
Homo sapiens
0.33
-
N-acetyl-alpha-D-galactosamine
wild-type, 37°C, pH 7.5
Homo sapiens
0.34
-
N-acetyl-alpha-D-galactosamine
mutant F444K, 37°C, pH 7.5
Homo sapiens
0.37
-
N-acetyl-alpha-D-glucosamine
mutant F444A, 37°C, pH 7.5
Homo sapiens
0.39
-
N-acetyl-alpha-D-glucosamine
mutant F444C, 37°C, pH 7.5
Homo sapiens
0.47
-
N-acetyl-alpha-D-mannosamine
mutant F444C, 37°C, pH 7.5
Homo sapiens
0.56
-
N-acetyl-alpha-D-galactosamine
mutant F444S, 37°C, pH 7.5
Homo sapiens
0.65
-
N-acetyl-alpha-D-mannosamine
mutant F444R, 37°C, pH 7.5
Homo sapiens
0.69
-
N-acetyl-alpha-D-galactosamine
mutant F444W, 37°C, pH 7.5
Homo sapiens
0.79
-
N-acetyl-alpha-D-mannosamine
wild-type, 37°C, pH 7.5
Homo sapiens
0.93
-
N-acetyl-alpha-D-mannosamine
mutant F444A, 37°C, pH 7.5
Homo sapiens
0.95
-
N-acetyl-alpha-D-galactosamine
mutant F444C, 37°C, pH 7.5
Homo sapiens
0.95
-
N-acetyl-alpha-D-mannosamine
mutant F444K, 37°C, pH 7.5
Homo sapiens
4.1
-
N-acetyl-alpha-D-mannosamine
mutant F444S, 37°C, pH 7.5
Homo sapiens
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Homo sapiens
Q01415
isoform GALK2
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ATP + N-acetyl-alpha-D-galactosamine
-
721309
Homo sapiens
ADP + N-acetyl-alpha-D-galactosamine 1-phosphate
-
-
-
?
ATP + N-acetyl-alpha-D-glucosamine
-
721309
Homo sapiens
ADP + N-acetyl-alpha-D-glucosamine 1-phosphate
-
-
-
?
ATP + N-acetyl-alpha-D-mannosamine
-
721309
Homo sapiens
ADP + N-acetyl-alpha-D-mannosamine 1-phosphate
-
-
-
?
Turnover Number [1/s]
Turnover Number Minimum [1/s]
Turnover Number Maximum [1/s]
Substrate
Commentary
Organism
Structure
0.053
-
N-acetyl-alpha-D-mannosamine
mutant F444H, 37°C, pH 7.5
Homo sapiens
0.063
-
N-acetyl-alpha-D-glucosamine
mutant F444S, 37°C, pH 7.5
Homo sapiens
0.066
-
N-acetyl-alpha-D-mannosamine
mutant F444C, 37°C, pH 7.5
Homo sapiens
0.071
-
N-acetyl-alpha-D-glucosamine
mutant F444R, 37°C, pH 7.5
Homo sapiens
0.072
-
N-acetyl-alpha-D-glucosamine
mutant F444H, 37°C, pH 7.5
Homo sapiens
0.087
-
N-acetyl-alpha-D-glucosamine
mutant F444C, 37°C, pH 7.5
Homo sapiens
0.11
-
N-acetyl-alpha-D-glucosamine
mutant F444A, 37°C, pH 7.5
Homo sapiens
0.16
-
N-acetyl-alpha-D-glucosamine
wild-type, 37°C, pH 7.5
Homo sapiens
0.18
-
N-acetyl-alpha-D-glucosamine
mutant F444K, 37°C, pH 7.5
Homo sapiens
0.19
-
N-acetyl-alpha-D-mannosamine
mutant F444R, 37°C, pH 7.5; wild-type, 37°C, pH 7.5
Homo sapiens
0.23
-
N-acetyl-alpha-D-mannosamine
mutant F444A, 37°C, pH 7.5
Homo sapiens
0.25
-
N-acetyl-alpha-D-mannosamine
mutant F444K, 37°C, pH 7.5
Homo sapiens
0.4
-
N-acetyl-alpha-D-mannosamine
mutant F444S, 37°C, pH 7.5
Homo sapiens
0.62
-
N-acetyl-alpha-D-galactosamine
mutant F444W, 37°C, pH 7.5
Homo sapiens
0.72
-
N-acetyl-alpha-D-galactosamine
mutant F444R, 37°C, pH 7.5
Homo sapiens
1
-
N-acetyl-alpha-D-galactosamine
mutant F444K, 37°C, pH 7.5
Homo sapiens
1.2
-
N-acetyl-alpha-D-galactosamine
wild-type, 37°C, pH 7.5
Homo sapiens
1.6
-
N-acetyl-alpha-D-galactosamine
mutant F444H, 37°C, pH 7.5
Homo sapiens
1.9
-
N-acetyl-alpha-D-galactosamine
mutant F444A, 37°C, pH 7.5
Homo sapiens
2.6
-
N-acetyl-alpha-D-galactosamine
mutant F444C, 37°C, pH 7.5
Homo sapiens
3.2
-
N-acetyl-alpha-D-galactosamine
mutant F444S, 37°C, pH 7.5
Homo sapiens
Cloned(Commentary) (protein specific)
Commentary
Organism
expression in Escherichia coli
Homo sapiens
Engineering (protein specific)
Amino acid exchange
Commentary
Organism
F444A
mutation in residue equivalent to residue Tyr379 of galactokinase, whose alteration dramatically enhances the substrate range of this enzyme. Mutation does not result in large changes to the specificity of the enzyme
Homo sapiens
F444C
mutation in residue equivalent to residue Tyr379 of galactokinase, whose alteration dramatically enhances the substrate range of this enzyme. Mutation does not result in large changes to the specificity of the enzyme but increases turnover rate with N-acetylgalactosamine
Homo sapiens
F444H
mutation in residue equivalent to residue Tyr379 of galactokinase, whose alteration dramatically enhances the substrate range of this enzyme. Mutation does not result in large changes to the specificity of the enzyme
Homo sapiens
F444K
mutation in residue equivalent to residue Tyr379 of galactokinase, whose alteration dramatically enhances the substrate range of this enzyme. Mutation does not result in large changes to the specificity of the enzyme
Homo sapiens
F444R
mutation in residue equivalent to residue Tyr379 of galactokinase, whose alteration dramatically enhances the substrate range of this enzyme. Mutation does not result in large changes to the specificity of the enzyme
Homo sapiens
F444S
mutation in residue equivalent to residue Tyr379 of galactokinase, whose alteration dramatically enhances the substrate range of this enzyme. Mutation does not result in large changes to the specificity of the enzyme but increases turnover rate with N-acetylgalactosamine
Homo sapiens
F444W
mutation in residue equivalent to residue Tyr379 of galactokinase, whose alteration dramatically enhances the substrate range of this enzyme. Mutation does not result in large changes to the specificity of the enzyme
Homo sapiens
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.006
-
ATP
mutant F444A, 37°C, pH 7.5, cosubstrate N-acetyl-alpha-D-galactosamine
Homo sapiens
0.009
-
ATP
mutant F444R, 37°C, pH 7.5, cosubstrate N-acetyl-alpha-D-galactosamine; wild-type, 37°C, pH 7.5, cosubstrate N-acetyl-alpha-D-glucosamine
Homo sapiens
0.011
-
ATP
mutant F444H, 37°C, pH 7.5, cosubstrate N-acetyl-alpha-D-galactosamine
Homo sapiens
0.013
-
ATP
mutant F444H, 37°C, pH 7.5, cosubstrate N-acetyl-alpha-D-glucosamine; mutant F444S, 37°C, pH 7.5, cosubstrate N-acetyl-alpha-D-glucosamine
Homo sapiens
0.015
-
ATP
mutant F444K, 37°C, pH 7.5, cosubstrate N-acetyl-alpha-D-galactosamine; mutant F444K, 37°C, pH 7.5, cosubstrate N-acetyl-alpha-D-glucosamine; mutant F444R, 37°C, pH 7.5, cosubstrate N-acetyl-alpha-D-glucosamine
Homo sapiens
0.017
-
ATP
mutant F444C, 37°C, pH 7.5, cosubstrate N-acetyl-alpha-D-mannosamine; mutant F444H, 37°C, pH 7.5, cosubstrate N-acetyl-alpha-D-mannosamine
Homo sapiens
0.018
-
ATP
mutant F444C, 37°C, pH 7.5, cosubstrate N-acetyl-alpha-D-glucosamine; wild-type, 37°C, pH 7.5, cosubstrate N-acetyl-alpha-D-galactosamine
Homo sapiens
0.019
-
ATP
mutant F444S, 37°C, pH 7.5, cosubstrate N-acetyl-alpha-D-galactosamine
Homo sapiens
0.024
-
ATP
mutant F444R, 37°C, pH 7.5, cosubstrate N-acetyl-alpha-D-mannosamine; mutant F444W, 37°C, pH 7.5, cosubstrate N-acetyl-alpha-D-galactosamine
Homo sapiens
0.025
-
ATP
mutant F444A, 37°C, pH 7.5, cosubstrate N-acetyl-alpha-D-glucosamine
Homo sapiens
0.027
-
ATP
mutant F444C, 37°C, pH 7.5, cosubstrate N-acetyl-alpha-D-galactosamine
Homo sapiens
0.028
-
ATP
mutant F444K, 37°C, pH 7.5, cosubstrate N-acetyl-alpha-D-mannosamine
Homo sapiens
0.032
-
ATP
wild-type, 37°C, pH 7.5, cosubstrate N-acetyl-alpha-D-mannosamine
Homo sapiens
0.039
-
ATP
mutant F444A, 37°C, pH 7.5, cosubstrate N-acetyl-alpha-D-mannosamine
Homo sapiens
0.051
-
N-acetyl-alpha-D-glucosamine
wild-type, 37°C, pH 7.5
Homo sapiens
0.12
-
N-acetyl-alpha-D-glucosamine
mutant F444K, 37°C, pH 7.5; mutant F444S, 37°C, pH 7.5
Homo sapiens
0.13
-
ATP
mutant F444S, 37°C, pH 7.5, cosubstrate N-acetyl-alpha-D-mannosamine
Homo sapiens
0.17
-
N-acetyl-alpha-D-galactosamine
mutant F444R, 37°C, pH 7.5
Homo sapiens
0.22
-
N-acetyl-alpha-D-glucosamine
mutant F444H, 37°C, pH 7.5
Homo sapiens
0.24
-
N-acetyl-alpha-D-galactosamine
mutant F444A, 37°C, pH 7.5
Homo sapiens
0.25
-
N-acetyl-alpha-D-mannosamine
mutant F444H, 37°C, pH 7.5
Homo sapiens
0.27
-
N-acetyl-alpha-D-galactosamine
mutant F444H, 37°C, pH 7.5
Homo sapiens
0.28
-
N-acetyl-alpha-D-glucosamine
mutant F444R, 37°C, pH 7.5
Homo sapiens
0.33
-
N-acetyl-alpha-D-galactosamine
wild-type, 37°C, pH 7.5
Homo sapiens
0.34
-
N-acetyl-alpha-D-galactosamine
mutant F444K, 37°C, pH 7.5
Homo sapiens
0.37
-
N-acetyl-alpha-D-glucosamine
mutant F444A, 37°C, pH 7.5
Homo sapiens
0.39
-
N-acetyl-alpha-D-glucosamine
mutant F444C, 37°C, pH 7.5
Homo sapiens
0.47
-
N-acetyl-alpha-D-mannosamine
mutant F444C, 37°C, pH 7.5
Homo sapiens
0.56
-
N-acetyl-alpha-D-galactosamine
mutant F444S, 37°C, pH 7.5
Homo sapiens
0.65
-
N-acetyl-alpha-D-mannosamine
mutant F444R, 37°C, pH 7.5
Homo sapiens
0.69
-
N-acetyl-alpha-D-galactosamine
mutant F444W, 37°C, pH 7.5
Homo sapiens
0.79
-
N-acetyl-alpha-D-mannosamine
wild-type, 37°C, pH 7.5
Homo sapiens
0.93
-
N-acetyl-alpha-D-mannosamine
mutant F444A, 37°C, pH 7.5
Homo sapiens
0.95
-
N-acetyl-alpha-D-galactosamine
mutant F444C, 37°C, pH 7.5
Homo sapiens
0.95
-
N-acetyl-alpha-D-mannosamine
mutant F444K, 37°C, pH 7.5
Homo sapiens
4.1
-
N-acetyl-alpha-D-mannosamine
mutant F444S, 37°C, pH 7.5
Homo sapiens
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ATP + N-acetyl-alpha-D-galactosamine
-
721309
Homo sapiens
ADP + N-acetyl-alpha-D-galactosamine 1-phosphate
-
-
-
?
ATP + N-acetyl-alpha-D-glucosamine
-
721309
Homo sapiens
ADP + N-acetyl-alpha-D-glucosamine 1-phosphate
-
-
-
?
ATP + N-acetyl-alpha-D-mannosamine
-
721309
Homo sapiens
ADP + N-acetyl-alpha-D-mannosamine 1-phosphate
-
-
-
?
Turnover Number [1/s] (protein specific)
Turnover Number Minimum [1/s]
Turnover Number Maximum [1/s]
Substrate
Commentary
Organism
Structure
0.053
-
N-acetyl-alpha-D-mannosamine
mutant F444H, 37°C, pH 7.5
Homo sapiens
0.063
-
N-acetyl-alpha-D-glucosamine
mutant F444S, 37°C, pH 7.5
Homo sapiens
0.066
-
N-acetyl-alpha-D-mannosamine
mutant F444C, 37°C, pH 7.5
Homo sapiens
0.071
-
N-acetyl-alpha-D-glucosamine
mutant F444R, 37°C, pH 7.5
Homo sapiens
0.072
-
N-acetyl-alpha-D-glucosamine
mutant F444H, 37°C, pH 7.5
Homo sapiens
0.087
-
N-acetyl-alpha-D-glucosamine
mutant F444C, 37°C, pH 7.5
Homo sapiens
0.11
-
N-acetyl-alpha-D-glucosamine
mutant F444A, 37°C, pH 7.5
Homo sapiens
0.16
-
N-acetyl-alpha-D-glucosamine
wild-type, 37°C, pH 7.5
Homo sapiens
0.18
-
N-acetyl-alpha-D-glucosamine
mutant F444K, 37°C, pH 7.5
Homo sapiens
0.19
-
N-acetyl-alpha-D-mannosamine
mutant F444R, 37°C, pH 7.5; wild-type, 37°C, pH 7.5
Homo sapiens
0.23
-
N-acetyl-alpha-D-mannosamine
mutant F444A, 37°C, pH 7.5
Homo sapiens
0.25
-
N-acetyl-alpha-D-mannosamine
mutant F444K, 37°C, pH 7.5
Homo sapiens
0.4
-
N-acetyl-alpha-D-mannosamine
mutant F444S, 37°C, pH 7.5
Homo sapiens
0.62
-
N-acetyl-alpha-D-galactosamine
mutant F444W, 37°C, pH 7.5
Homo sapiens
0.72
-
N-acetyl-alpha-D-galactosamine
mutant F444R, 37°C, pH 7.5
Homo sapiens
1
-
N-acetyl-alpha-D-galactosamine
mutant F444K, 37°C, pH 7.5
Homo sapiens
1.2
-
N-acetyl-alpha-D-galactosamine
wild-type, 37°C, pH 7.5
Homo sapiens
1.6
-
N-acetyl-alpha-D-galactosamine
mutant F444H, 37°C, pH 7.5
Homo sapiens
1.9
-
N-acetyl-alpha-D-galactosamine
mutant F444A, 37°C, pH 7.5
Homo sapiens
2.6
-
N-acetyl-alpha-D-galactosamine
mutant F444C, 37°C, pH 7.5
Homo sapiens
3.2
-
N-acetyl-alpha-D-galactosamine
mutant F444S, 37°C, pH 7.5
Homo sapiens
Other publictions for EC 2.7.1.157
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
721309
Kristiansson
N-acetylgalactosamine kinase: ...
Homo sapiens
Appl. Biochem. Biotechnol.
166
57-63
2012
-
-
1
-
7
-
-
36
-
-
-
-
-
2
-
-
-
-
-
-
-
-
3
-
-
-
-
21
-
-
-
-
-
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