BRENDA - Enzyme Database
show all sequences of 2.7.1.157

The intrinsic reactivity of ATP and the catalytic proficiencies of kinases acting on glucose, N-acetylgalactosamine, and homoserine: a thermodynamic analysis

Stockbridge, R.B.; Wolfenden, R.; J. Biol. Chem. 284, 22747-22757 (2009)

Data extracted from this reference:

KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
additional information
-
additional information
enzyme kinetics and thermodynamics, detailed overview
Homo sapiens
0.093
-
ATP
pH 7.0, 25°C
Homo sapiens
0.12
-
N-acetyl-D-galactosamine
pH 7.0, 25°C
Homo sapiens
Metals/Ions
Metals/Ions
Commentary
Organism
Structure
Mg2+
addition of Mg2+ leads to partly compensating changes in DELTAH and TDELTAS, accelerating the nonenzymatic methanolysis of ATP 11fold
Homo sapiens
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ATP + N-acetyl-D-galactosamine
Homo sapiens
-
ADP + N-acetyl-alpha-D-galactosamine 1-phosphate
-
-
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Homo sapiens
-
-
-
Reaction
Reaction
Commentary
Organism
ATP + N-acetyl-alpha-D-galactosamine = ADP + N-acetyl-alpha-D-galactosamine 1-phosphate
ATP hydrolysis and methanolysis reaction pathways, overview
Homo sapiens
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ATP + N-acetyl-D-galactosamine
-
704525
Homo sapiens
ADP + N-acetyl-alpha-D-galactosamine 1-phosphate
-
-
-
?
Temperature Optimum [°C]
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
25
-
assay at
Homo sapiens
Turnover Number [1/s]
Turnover Number Minimum [1/s]
Turnover Number Maximum [1/s]
Substrate
Commentary
Organism
Structure
2.5
-
ATP
pH 7.0, 25°C
Homo sapiens
2.5
-
N-acetyl-D-galactosamine
pH 7.0, 25°C
Homo sapiens
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
7
-
assay at
Homo sapiens
pH Range
pH Minimum
pH Maximum
Commentary
Organism
4.8
11
-
Homo sapiens
Cofactor
Cofactor
Commentary
Organism
Structure
ATP
addition of Mg2+ leads to partly compensating changes in DELTAH and TDELTAS, accelerating the nonenzymatic methanolysis of ATP 11fold. ATP hydrolysis and methanolysis reaction pathways, overview
Homo sapiens
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
ATP
addition of Mg2+ leads to partly compensating changes in DELTAH and TDELTAS, accelerating the nonenzymatic methanolysis of ATP 11fold. ATP hydrolysis and methanolysis reaction pathways, overview
Homo sapiens
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
additional information
-
additional information
enzyme kinetics and thermodynamics, detailed overview
Homo sapiens
0.093
-
ATP
pH 7.0, 25°C
Homo sapiens
0.12
-
N-acetyl-D-galactosamine
pH 7.0, 25°C
Homo sapiens
Metals/Ions (protein specific)
Metals/Ions
Commentary
Organism
Structure
Mg2+
addition of Mg2+ leads to partly compensating changes in DELTAH and TDELTAS, accelerating the nonenzymatic methanolysis of ATP 11fold
Homo sapiens
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ATP + N-acetyl-D-galactosamine
Homo sapiens
-
ADP + N-acetyl-alpha-D-galactosamine 1-phosphate
-
-
?
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ATP + N-acetyl-D-galactosamine
-
704525
Homo sapiens
ADP + N-acetyl-alpha-D-galactosamine 1-phosphate
-
-
-
?
Temperature Optimum [°C] (protein specific)
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
25
-
assay at
Homo sapiens
Turnover Number [1/s] (protein specific)
Turnover Number Minimum [1/s]
Turnover Number Maximum [1/s]
Substrate
Commentary
Organism
Structure
2.5
-
ATP
pH 7.0, 25°C
Homo sapiens
2.5
-
N-acetyl-D-galactosamine
pH 7.0, 25°C
Homo sapiens
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
7
-
assay at
Homo sapiens
pH Range (protein specific)
pH Minimum
pH Maximum
Commentary
Organism
4.8
11
-
Homo sapiens
Other publictions for EC 2.7.1.157
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
721309
Kristiansson
N-acetylgalactosamine kinase: ...
Homo sapiens
Appl. Biochem. Biotechnol.
166
57-63
2012
-
-
1
-
7
-
-
36
-
-
-
-
-
2
-
-
-
-
-
-
-
-
3
-
-
-
-
21
-
-
-
-
-
-
-
-
-
1
-
-
7
-
-
-
-
36
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
21
-
-
-
-
-
-
-
-
-
-
704525
Stockbridge
The intrinsic reactivity of AT ...
Homo sapiens
J. Biol. Chem.
284
22747-22757
2009
-
-
-
-
-
-
-
3
-
1
-
1
-
2
-
-
-
1
-
-
-
-
1
-
1
-
-
2
1
1
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
3
-
1
-
1
-
-
-
-
-
-
-
-
1
-
1
-
-
2
1
1
-
-
-
-
-
-
-
-
709300
Agnew
Mechanistic studies on human N ...
Homo sapiens
J. Enzyme Inhib. Med. Chem.
25
370-376
2009
-
-
1
-
-
-
3
3
-
1
-
1
-
4
-
-
1
1
-
-
-
-
3
-
-
-
-
3
-
2
-
1
1
-
-
-
-
2
1
-
-
-
-
4
1
4
-
1
-
1
-
-
-
1
-
-
-
-
3
-
-
-
-
3
-
2
-
-
-
-
-
-
-
-
659494
Thoden
The molecular architecture of ...
Homo sapiens
J. Biol. Chem.
280
32784-32791
2005
-
-
1
1
-
-
-
-
-
-
-
1
-
2
-
-
1
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
672583
Bourgeaux
Two-step enzymatic synthesis o ...
Homo sapiens
Bioorg. Med. Chem. Lett.
15
5459-5462
2005
-
1
1
-
-
-
-
1
-
-
1
-
-
3
-
-
1
-
-
-
-
1
1
1
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
1
-
-
-
1
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
659129
Pastuszak
Kidney N-acetylgalactosamine ( ...
Homo sapiens, Oryctolagus cuniculus, Sus scrofa
J. Biol. Chem.
271
20776-20782
1996
-
-
-
-
-
-
-
2
1
3
1
-
-
5
-
-
1
-
-
8
1
-
7
1
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
1
3
1
-
-
-
-
1
-
8
1
-
7
1
-
-
-
-
1
1
-
-
-
-
-
-
-
-
659130
Pastuszak
Identification of the GalNAc k ...
Homo sapiens, Sus scrofa
J. Biol. Chem.
271
23653-23656
1996
-
-
1
-
-
-
-
2
2
-
1
-
-
5
-
-
-
-
-
2
-
-
4
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
2
2
-
1
-
-
-
-
-
-
2
-
-
4
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-