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Literature summary for 2.7.1.154 extracted from

  • Chikh, A.; Ferro, R.; Abbott, J.J.; Pineiro, R.; Buus, R.; Iezzi, M.; Ricci, F.; Bergamaschi, D.; Ostano, P.; Chiorino, G.; Lattanzio, R.; Broggini, M.; Piantelli, M.; Maffucci, T.; Falasca, M.
    Class II phosphoinositide 3-kinase C2alpha regulates a novel signaling pathway involved in breast cancer progression (2016), Oncotarget, 7, 18325-18345.
    View publication on PubMed
Search for more literature for 2.7.1.154

Cloned(Commentary)

Cloned (Comment) Organism
gene PIK3C2B, quantitative expression analysis Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information enzyme downregulation by specific shRNA in MCF-7, T-47D, and MDA-MB-231 cancer cells Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens O00750 gene PIK3C2B
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Source Tissue

Source Tissue Comment Organism Textmining
BRE-80 cell
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 Homo sapiens
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breast non-neoplastic breast tissues Homo sapiens
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breast cancer cell isozyme PI3K-C2beta is overexpressed in human breast cancer cell lines Homo sapiens
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HBL-100 cell
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 Homo sapiens
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lymph node PI3K-C2beta is highly expressed in lymph-nodes metastases compared to matching primary tumors Homo sapiens
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MCF-10A cell
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 Homo sapiens
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MCF-7 cell
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 Homo sapiens
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MDA-MB-231 cell
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 Homo sapiens
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T-47D cell
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 Homo sapiens
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Synonyms

Synonyms Comment Organism
class II phosphoinositide 3-kinase C2beta
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 Homo sapiens
PI3K-C2beta
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 Homo sapiens

General Information

General Information Comment Organism
malfunction downregulation of PI3K-C2beta in breast cancer cell lines reduces colony formation, induces cell cycle arrest and inhibits tumor growth, in particular in an estrogen-dependent in vivo xenograft. PI3K-C2beta inhibits breast cancer cell invasion in vitro and breast cancer metastasis in vivo Homo sapiens
physiological function class II phosphoinositide 3-kinase C2beta regulates a novel signaling pathway involved in breast cancer progression. Isozyme PI3K-C2beta regulates breast cancer cell growth in vitro and in vivo, PI3K-C2beta expression in breast tissues is correlated with the proliferative status of the tumor. Analsis of the mechanism of the PI3K-C2beta-dependent regulation of cell cycle progression and cell growth revealed that PI3K-C2beta regulates cyclin B1 protein levels through modulation of microRNA miR-449a levels. PI3K-C2beta may represent a key molecular switch that regulates a rate-limiting step in breast tumor progression and therefore it may be targeted to limit breast cancer spread. PI3K-C2beta regulates cyclin B1 expression through modulation of miR-449a, miR-449a levels are downregulated in primary human breast cancer samples, and cyclin B1/miR-449a expression through modulation of LEF1/beta catenin pathway in MDA-MB-231 cells. PI3K-C2beta regulates senescence via miR-449 regulation Homo sapiens