Protein Variants | Comment | Organism |
---|---|---|
additional information | generation of PI3KC2beta-silenced neuroblastoma cell lines | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O00750 | gene PIK3C2B | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
neuroblastoma cell | PI3K class IIbeta (PI3KC2beta) and its regulator intersectin 1 (ITSN1) are highly expressed in primary neuroblastoma tumors and cell lines | Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
phosphatidylinositol 3-kinase class 2 beta | - |
Homo sapiens |
PI3KC2beta | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | PI3KC2beta-silencing inhibits early stages of neuroblastoma tumorigenic growth, but does not alter apoptotic or endocytic pathways, and silencing of the enzyme's regulator intersectin 1, ITSN1, also dramatically reduces the tumorigenic potential of neuroblastoma cells. Overexpression of PI3KC2beta rescues the anchorage-independent growth of ITSN1-silenced cells suggesting that PI3KC2beta mediates ITSN1's function in neuroblastoma cells. Silencing ITSN1 or PI3KC2beta decreases AKT activation in neuroblastoma cells | Homo sapiens |
physiological function | phosphatidylinositol 3-kinase class 2 beta isoform, PI3KC2beta, contributes to neuroblastoma tumorigenesis. Activation of the PI3K target AKT is frequent in neuroblastoma and correlates with poor prognosis | Homo sapiens |