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Literature summary for 2.7.1.153 extracted from

  • Li, D.; Yang, J.; Ma, H.; Sun, C.; Feng, R.
    Inositol polyphosphate-4-phosphatase type II and rucaparib treatment inhibit the growth of osteosarcoma cells dependent on phosphoinositide 3-kinase/protein kinase B pathway (2018), J. Cell. Biochem., 119, 9899-9909 .
    View publication on PubMed
Search for more literature for 2.7.1.153

Cloned(Commentary)

Cloned (Comment) Organism
quantitative RT-PCR enzyme expression analysis Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information a combination of INPP4B overexpression and rucaparib blocks the PI3K/AKT signal pathway Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate Homo sapiens
-
 ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
osteosarcoma cell
-
 Homo sapiens
-
SAOS-2 cell
-
 Homo sapiens
-
U2-OS cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
 Homo sapiens ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
-
 ?

Synonyms

Synonyms Comment Organism
phosphatidylinositol-4,5-bisphosphate 3-kinase
-
 Homo sapiens
phosphoinositide 3-kinase
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction a combination of INPP4B overexpression and rucaparib blocks the PI3K/AKT signal pathway Homo sapiens
metabolism inositol polyphosphate-4-phosphatase type II and rucaparib treatment inhibit the growth of osteosarcoma cells dependent on phosphoinositide 3-kinase/protein kinase B pathway, combined effects of INPP4B and rucaparib on cell cycle, apoptosis and phosphoinositide 3-kinase/protein kinase B (PI3K/AKT) signal pathway. INPP4B plays an important role in the development of tumors, which can maintain the balance of internal inositol phosphate, suppress the activation of phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K)/protein kinase B (AKT) signal pathway, and block cells malignant transformation Homo sapiens