Literature summary for 2.7.1.153 extracted from

Large, J.M.; Torr, J.E.; Raynaud, F.I.; Clarke, P.A.; Hayes, A.; Stefano, F.d.; Urban, F.; Shuttleworth, S.J.; Saghir, N.; Sheldrake, P.; Workman, P.; McDonald, E.
Preparation and evaluation of trisubstituted pyrimidines as phosphatidylinositol 3-kinase inhibitors. 3-Hydroxyphenol analogues and bioisosteric replacements (2011), Bioorg. Med. Chem., 19, 836-851.

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Cloned(Commentary)

Cloned (Comment)	Organism
-	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
3-(2-morpholino-6-(2-(pyridin-4-yl)ethylamino)pyrimidin-4-yl)phenol	-	Homo sapiens
3-(2-morpholino-6-(pyridin-2-ylmethoxy)pyrimidin-4-yl)phenol	-	Homo sapiens
3-(4-morpholino-6-(pyridin-2-yl)pyrimidin-2-yl)phenol	-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P42336	phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
IGROV-1 cell	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
PIK3CA	-	Homo sapiens

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.000044	-	isoform p110gamma, pH 7.4, 22°C	Homo sapiens	3-(4-morpholino-6-(pyridin-2-yl)pyrimidin-2-yl)phenol
0.000062	-	isoform p110alpha, pH 7.4, 22°C	Homo sapiens	3-(4-morpholino-6-(pyridin-2-yl)pyrimidin-2-yl)phenol
0.0001	-	isoform p110beta, pH 7.4, 22°C	Homo sapiens	3-(4-morpholino-6-(pyridin-2-yl)pyrimidin-2-yl)phenol
0.00011	-	isoform p110alpha, pH 7.4, 22°C	Homo sapiens	3-(2-morpholino-6-(pyridin-2-ylmethoxy)pyrimidin-4-yl)phenol
0.00014	-	isoform p110alpha, pH 7.4, 22°C	Homo sapiens	3-(2-morpholino-6-(2-(pyridin-4-yl)ethylamino)pyrimidin-4-yl)phenol
0.00037	-	isoform p110beta, pH 7.4, 22°C	Homo sapiens	3-(2-morpholino-6-(pyridin-2-ylmethoxy)pyrimidin-4-yl)phenol
0.00073	-	isoform p110gamma, pH 7.4, 22°C	Homo sapiens	3-(2-morpholino-6-(pyridin-2-ylmethoxy)pyrimidin-4-yl)phenol
0.00074	-	isoform p110gamma, pH 7.4, 22°C	Homo sapiens	3-(2-morpholino-6-(2-(pyridin-4-yl)ethylamino)pyrimidin-4-yl)phenol
0.0016	-	isoform p110beta, pH 7.4, 22°C	Homo sapiens	3-(2-morpholino-6-(2-(pyridin-4-yl)ethylamino)pyrimidin-4-yl)phenol

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Release 2023.1 (January 2023)