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Literature summary for 2.7.1.153 extracted from

  • Furuya, F.; Lu, C.; Guigon, C.J.; Cheng, S.Y.
    Nongenomic activation of phosphatidylinositol 3-kinase signaling by thyroid hormone receptors (2009), Steroids, 74, 628-634.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.1.153

Activating Compound

Activating Compound Comment Organism Structure
thyroid receptor i.e. PV, nongenomic activation of phosphatidylinositol 3-kinase signaling by thyroid hormone receptors, overview. PI3Kactivation through thyroid recptor via protein–protein interaction, i.e. binding to regulatory subunit p85alpha. The thyroid receptorbeta mutant physically interacts with the regulatory p85alpha subunit of PI3K to activate the downstream AKT-mammalian target of rapamycin and p70S6K and PI3K-integrin-linked kinase-matrix metalloproteinase-2 signaling pathways. PI3K activation results in increased cell proliferation, motility, migration, and metastasis. Nuclear receptor corepressor, NCoR, is a regulator of thyroid receptor-activated PI3K signaling Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + Akt Mus musculus
-
 ADP + Akt phosphate
-
 ?
ATP + p70S6K Mus musculus
-
 ADP + p70S6K phosphate
-
 ?
additional information Mus musculus molecular model for the regulation of PI3K signaling by NCoR, a receptor corepressor and regulator of thyroid receptor-activated PI3K signaling ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
thyroid cancer cell
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + Akt
-
 Mus musculus ADP + Akt phosphate
-
 ?
ATP + Akt phosphorylation at Ser473 Mus musculus ADP + Akt phosphate
-
 ?
ATP + p70S6K
-
 Mus musculus ADP + p70S6K phosphate
-
 ?
additional information molecular model for the regulation of PI3K signaling by NCoR, a receptor corepressor and regulator of thyroid receptor-activated PI3K signaling Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
PI3K
-
 Mus musculus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Mus musculus

General Information

General Information Comment Organism
malfunction binding of thyroid receptor to p85alpha activates PI3K/AKT signaling promoting thyroid carcinogenesis by increasing cell proliferation and tumor metastasis Mus musculus
physiological function PI3K activation results in increased cell proliferation, motility, migration, and metastasis. Inhibition of PI3K signaling delays tumor progression and blocks metastasis of thyroid cancer Mus musculus