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Literature summary for 2.7.1.151 extracted from

  • Ahmed, I.; Sbodio, J.I.; Harraz, M.M.; Tyagi, R.; Grima, J.C.; Albacarys, L.K.; Hubbi, M.E.; Xu, R.; Kim, S.; Paul, B.D.; Snyder, S.H.
    Huntingtons disease: neural dysfunction linked to inositol polyphosphate multikinase (2015), Proc. Natl. Acad. Sci. USA, 112, 9751-9756.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.1.151

Application

Application Comment Organism
medicine delivery of IPMK in a transgenic Huntington's disease model improves pathological changes and motor performance. The Ctip2-IPMK-Akt signaling pathway provides a previously unidentified therapeutic target for Huntington's disease Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
gene impk, adeno-associated virus serotype 2-mediated delivery of IPMK into mouse brain, in the striatum of R6/2 Huntington's disease mice Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
soluble
-
 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens inositol polyphosphate multikinase is an enzyme that displays soluble inositol phosphate kinase activity, lipid kinase activity, and various noncatalytic interactions ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q8NFU5 gene impk
-

Source Tissue

Source Tissue Comment Organism Textmining
brain from Huntington's disease patients and healthy persons Homo sapiens
-
brain cortex
-
 Homo sapiens
-
cerebellum
-
 Homo sapiens
-
hippocampus
-
 Homo sapiens
-
striatum from Huntington's disease patients and healthy persons, severe loss of IPMK in the striatum of Huntington's disease patients Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information inositol polyphosphate multikinase is an enzyme that displays soluble inositol phosphate kinase activity, lipid kinase activity, and various noncatalytic interactions Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
Impk
-
 Homo sapiens
inositol polyphosphate multikinase
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction severe loss of IPMK in the striatum of Huntington's disease patients, the depletion reflects mHtt-induced impairment of COUP-TF-interacting protein 2 (Ctip2), a striatal-enriched transcription factor for IPMK, as well as alterations in IPMK protein stability. IPMK overexpression reverses the metabolic activity deficit in a cell model of Huntington's disease. IPMK depletion appears to mediate neural dysfunction, because intrastriatal delivery of IPMK abates the progression of motor abnormalities and rescues striatal pathology in transgenic murine models of Huntington's disease Homo sapiens
metabolism IPMK expression rescues mHtt-induced deficits in mitochondrial metabolic activity. Delivery of IPMK in a transgenic Huntington's disease model improves pathological changes and motor performance. The Ctip2-IPMK-Akt signaling pathway provides a previously unidentified therapeutic target for Huntington's disease Homo sapiens