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Literature summary for 2.7.1.151 extracted from

  • Kim, S.; Kim, S.F.; Maag, D.; Maxwell, M.J.; Resnick, A.C.; Juluri, K.R.; Chakraborty, A.; Koldobskiy, M.A.; Cha, S.H.; Barrow, R.; Snowman, A.M.; Snyder, S.H.
    Amino acid signaling to mTOR mediated by inositol polyphosphate multikinase (2011), Cell Metab., 13, 215-221.
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Mus musculus
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 bifunctional inositol phosphate kinase and lipid kinase
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Source Tissue

Source Tissue Comment Organism Textmining
fibroblast embryonic fibroblast cell Mus musculus
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Synonyms

Synonyms Comment Organism
IPMK
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 Mus musculus

General Information

General Information Comment Organism
physiological function inositol polyphosphate multikinase regulates amino acid signaling to mammalian target of rapamycin in complex with raptor, mTORC1. This regulation is independent of IPMK's catalytic function, instead reflecting its binding with mammalian target of rapamycin, mTOR, and raptor, which maintains the mTOR-raptor association. Inositol polyphosphate multikinase appears to be a physiologic mTOR cofactor, serving as a determinant of mTORC1 stability and amino acid-induced mTOR signaling Mus musculus