Literature summary for 2.7.1.151 extracted from

Riley, A.M.; Deleu, S.; Qian, X.; Mitchell, J.; Chung, S.; Adelt, S.; Vogel, G.; Potter, B.V.; Shears, S.B.
On the contribution of stereochemistry to human ITPK1 specificity: Ins(1,4,5,6)P4 is not a physiologic substrate (2006), FEBS Lett., 580, 324-330.

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Inhibitors

Inhibitors	Comment	Organism	Structure
inositol(1,3,4)-trisphosphate	potently inhibits hITPK1 activity towards insositol (3,4,5,6)-tetrakisphosphate, IC50: 0.0076 mM	Homo sapiens
inositol(3,5,6)-trisphosphate	IC50: 0.1 mM	Homo sapiens

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.00018	-	inositol (1,4,5,6)-tetrakisphosphate	-	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Homo sapiens	inositol (1,4,5,6)-tetrakisphosphate is not a physiological substrate	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	recombinant	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
inositol (1,4,5,6)-tetrakisphosphate + ATP	hITPK1 has more than 13000fold preference for inositol (3,4,5,6)-tetrakisphosphate over its enantiomer inositol (1,4,5,6)-tetrakisphosphate	Homo sapiens	inositol (1,3,4,5,6)-pentakisphosphate + ADP	-	?
inositol (3,4,5,6)-tetrakisphosphate + ATP	hITPK1 has more than 13000fold preference for inositol (3,4,5,6)-tetrakisphosphate over its enantiomer inositol (1,4,5,6)-tetrakisphosphate	Homo sapiens	inositol (1,3,4,5,6)-pentakisphosphate + ADP	-	?
additional information	inositol (1,4,5,6)-tetrakisphosphate is not a physiological substrate	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
ITPK1	-	Homo sapiens

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.00015	-	inositol (1,3,4)-trisphosphate	-	Homo sapiens
0.002	-	inositol (3,5,6)-trisphosphate	-	Homo sapiens

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.0076	-	potently inhibits hITPK1 activity towards insositol (3,4,5,6)-tetrakisphosphate, IC50: 0.0076 mM	Homo sapiens	inositol(1,3,4)-trisphosphate
0.1	-	IC50: 0.1 mM	Homo sapiens	inositol(3,5,6)-trisphosphate

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Release 2023.1 (January 2023)