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Literature summary for 2.7.1.151 extracted from

  • Seeds, A.M.; Bastidas, R.J.; York, J.D.
    Molecular definition of a novel inositol polyphosphate metabolic pathway initiated by inositol 1,4,5-trisphosphate 3-kinase activity in Saccharomyces cerevisiae (2005), J. Biol. Chem., 280, 27654-27661.
    View publication on PubMed
Search for more literature for 2.7.1.151

Cloned(Commentary)

Cloned (Comment) Organism
genetic map of inositol metabolism, overexpression of isozyme Kcs1 can complement isozyme Ipk2 deficiency Saccharomyces cerevisiae

Protein Variants

Protein Variants Comment Organism
additional information growth of an enzyme-deficient strain can be rescued by expression of either 1D-myo-inositol 1,4,5-trisphosphate 3-kinase or 6-kinase at high temperatures, but only 1D-myo-inositol 1,4,5-trisphosphate 6-kinase expression enables the strain to grow on ornithine Saccharomyces cerevisiae

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate Saccharomyces cerevisiae isozyme Kcs1 ADP + diphosphoinositol pentakisphosphate
-
 ?
ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate Saccharomyces cerevisiae isozyme Kcs1 ADP + diphosphoinositol tetrakisphosphate
-
 ?
ATP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate Saccharomyces cerevisiae preferred substrate of isozyme Ipk2 ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate
-
 ?
ATP + 1D-myo-inositol 1,4,5-trisphosphate Saccharomyces cerevisiae the enzyme initiates a inositol polyphosphate pathway, isozyme Kcs1 is also involved, inositol metabolism, overview ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
 ?
ATP + 1D-myo-inositol 1,4,5-trisphosphate Saccharomyces cerevisiae preferred substrate of isozyme Ipk2 ADP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate isozyme Kcs1 Saccharomyces cerevisiae ADP + diphosphoinositol pentakisphosphate
-
 ?
ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate isozyme Kcs1 Saccharomyces cerevisiae ADP + diphosphoinositol tetrakisphosphate
-
 ?
ATP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate preferred substrate of isozyme Ipk2 Saccharomyces cerevisiae ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate
-
 ?
ATP + 1D-myo-inositol 1,4,5-trisphosphate the enzyme initiates a inositol polyphosphate pathway, isozyme Kcs1 is also involved, inositol metabolism, overview Saccharomyces cerevisiae ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
 ?
ATP + 1D-myo-inositol 1,4,5-trisphosphate isozyme Ipk2 and isozyme Kcs1 Saccharomyces cerevisiae ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
 ?
ATP + 1D-myo-inositol 1,4,5-trisphosphate preferred substrate of isozyme Ipk2 Saccharomyces cerevisiae ADP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate
-
 ?

Synonyms

Synonyms Comment Organism
Arg82
-
 Saccharomyces cerevisiae
inositol 1,4,5-trisphosphate 3-kinase
-
 Saccharomyces cerevisiae
inositol polyphosphate multikinase
-
 Saccharomyces cerevisiae
Ipk2
-
 Saccharomyces cerevisiae
Kcs1
-
 Saccharomyces cerevisiae

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Saccharomyces cerevisiae

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 assay at Saccharomyces cerevisiae

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Saccharomyces cerevisiae