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Literature summary for 2.7.1.149 extracted from

  • Mathre, S.; Reddy, K.B.; Ramya, V.; Krishnan, H.; Ghosh, A.; Raghu, P.
    Functional analysis of the biochemical activity of mammalian phosphatidylinositol 5 phosphate 4-kinase enzymes (2019), Biosci. Rep., 39, BSR20182210 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.1.149

Cloned(Commentary)

Cloned (Comment) Organism
expressed in a enzyme-deficient mutant of Drosophila melanogaster Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Homo sapiens 5737
-
plasma membrane
-
 Homo sapiens 5886
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ 20 mM used in assay conditions Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + 1-phosphatidyl-1D-myo-inositol 5-phosphate Homo sapiens
-
 ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1-phosphatidyl-1D-myo-inositol 5-phosphate
-
 Homo sapiens ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
 ?

Synonyms

Synonyms Comment Organism
phosphatidylinositol 5 phosphate 4-kinase
-
 Homo sapiens
PIP4K
-
 Homo sapiens
Pip4k2a isoform Homo sapiens
Pip4k2b isoform Homo sapiens
PIP4K2C isoform Homo sapiens

General Information

General Information Comment Organism
physiological function human enzyme isoforms are able to rescue salivary gland cell size defects in the Drosophila enzyme-deficient mutant Homo sapiens