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Literature summary for 2.7.1.149 extracted from

  • Giudici, M.; Clarke, J.; Irvine, R.
    Phosphatidylinositol 5-phosphate 4-kinase gamma (PI5P4Kgamma), a lipid signalling enigma (2016), Adv. Biol. Regul., 61, 47-50 .
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
N165I the mutation in isoform PI5P4Kgamma leads to resistance to inhibitor NIH-12848 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
AG-538 at a concentration of 0.02 mM, AG-538 induces an almost complete inhibition of isoform PI5P4Kalpha and inhibits isoforms PI5P4Ks beta and gamma by 90% and 85%, respectively Homo sapiens
NIH-12848 very specific inhibitor Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate Homo sapiens
-
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
-
Homo sapiens ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
?

Synonyms

Synonyms Comment Organism
phosphatidylinositol 5-phosphate 4-kinase gamma
-
Homo sapiens
PI5P4Kalpha isoform Homo sapiens
PI5P4Kbeta isoform Homo sapiens
PI5P4Kgamma isoform Homo sapiens