Protein Variants | Comment | Organism |
---|---|---|
N165I | the mutation in isoform PI5P4Kgamma leads to resistance to inhibitor NIH-12848 | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
AG-538 | at a concentration of 0.02 mM, AG-538 induces an almost complete inhibition of isoform PI5P4Kalpha and inhibits isoforms PI5P4Ks beta and gamma by 90% and 85%, respectively | Homo sapiens | |
NIH-12848 | very specific inhibitor | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate | Homo sapiens | - |
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate | - |
Homo sapiens | ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
phosphatidylinositol 5-phosphate 4-kinase gamma | - |
Homo sapiens |
PI5P4Kalpha | isoform | Homo sapiens |
PI5P4Kbeta | isoform | Homo sapiens |
PI5P4Kgamma | isoform | Homo sapiens |