Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.1.149 extracted from

  • Clarke, J.; Irvine, R.
    The activity, evolution and association of phosphatidylinositol 5-phosphate 4-kinases (2012), Adv. Biol. Regul., 52, 40-45.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
PI5P4Kalpha is predominantly in the cytoplasm, principally cytosolic, when recombinantly expressed Mammalia

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol recombinantly expressed PI5P4Kalpha Mammalia 5829
-
membrane PI5P4Kalpha is membrane-bound in DT40 cells with a significant amount of endogenous PI5P4Kalpha in the nucleus Mammalia 16020
-
additional information analysis of subcellular localization of native and recombinant isozyme PI5P4Kalpha, overview Mammalia
-
-
nucleus PI5P4Kalpha is membrane-bound in DT40 cells with a significant amount of endogenous PI5P4Kalpha in the nucleus Mammalia 5634
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Mammalia

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + 1-phosphatidyl-1D-myo-inositol 5-phosphate Mammalia
-
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
?

Organism

Organism UniProt Comment Textmining
Mammalia
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
DT-40 cell
-
Mammalia
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1-phosphatidyl-1D-myo-inositol 5-phosphate
-
Mammalia ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
?

Synonyms

Synonyms Comment Organism
phosphatidylinositol 5-phosphate 4-kinase
-
Mammalia
PI5P4K
-
Mammalia
PI5P4Kalpha
-
Mammalia

Cofactor

Cofactor Comment Organism Structure
ATP
-
Mammalia

General Information

General Information Comment Organism
evolution PI5P4Kalpha is present in all vertebrates, and a few organisms are missing either beta or gamma. Several key structural differences between the three mammalian PI5P4Ks largely account for their different activities, e.g. a glycine-rich loop supposed to be involved with substrate interaction Mammalia