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Literature summary for 2.7.1.138 extracted from

  • Mietla, J.A.; Wijesinghe, D.S.; Hoeferlin, L.A.; Shultz, M.D.; Natarajan, R.; Fowler, A.A.; Chalfant, C.E.
    Characterization of eicosanoid synthesis in a genetic ablation model of ceramide kinase (2013), J. Lipid Res., 54, 1834-1847.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.1.138

Protein Variants

Protein Variants Comment Organism
additional information generation of CERK-/- knockout mice and enzyme silencing by siRNA Mus musculus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + ceramide Mus musculus
-
 ADP + ceramide 1-phosphate
-
 ?
ATP + ceramide Mus musculus BALB/c
-
 ADP + ceramide 1-phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus Q8K4Q7 gene CERK
-
Mus musculus BALB/c Q8K4Q7 gene CERK
-

Source Tissue

Source Tissue Comment Organism Textmining
macrophage
-
 Mus musculus
-
MEF cell primary mouse embryonic fibroblasts Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + ceramide
-
 Mus musculus ADP + ceramide 1-phosphate
-
 ?
ATP + ceramide
-
 Mus musculus BALB/c ADP + ceramide 1-phosphate
-
 ?

Synonyms

Synonyms Comment Organism
CERK
-
 Mus musculus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Mus musculus

General Information

General Information Comment Organism
malfunction genetic ablation of CERK reduces basal ceramide 1-phosphate levels. CERK-/- knockout mouse cells show 52-74% reduced ceramide 1-phosphate contents and significantly lower levels of multiple eicosanoids compared to wild-type. Induction of eicosanoid synthesis by calcium ionophore is significantly reduced in the CERK-/- primary mouse embryonic fibroblasts. The CERK-/- mouse has adapted to loss of CERK in regards to airway hyper-responsiveness as compared with CERK siRNA treatment. Eicosanoids produced by immortalized primary mouse embryonic fibroblasts, overview Mus musculus
physiological function a role for ceramide kinase in the production of eicosanoids. The initial rate-limiting step in eicosanoid biosynthesis is started by the activation of group IVA phospholipase A, 2cPLA2alpha, which is activated by direct binding of the C2 domain to ceramide-1-phosphate Mus musculus