BRENDA - Enzyme Database show
show all sequences of 2.7.1.138

Characterization of eicosanoid synthesis in a genetic ablation model of ceramide kinase

Mietla, J.A.; Wijesinghe, D.S.; Hoeferlin, L.A.; Shultz, M.D.; Natarajan, R.; Fowler, A.A.; Chalfant, C.E.; J. Lipid Res. 54, 1834-1847 (2013)

Data extracted from this reference:

Engineering
Amino acid exchange
Commentary
Organism
additional information
generation of CERK-/- knockout mice and enzyme silencing by siRNA
Mus musculus
Metals/Ions
Metals/Ions
Commentary
Organism
Structure
Mg2+
required
Mus musculus
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ATP + ceramide
Mus musculus
-
ADP + ceramide 1-phosphate
-
-
?
ATP + ceramide
Mus musculus BALB/c
-
ADP + ceramide 1-phosphate
-
-
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Mus musculus
Q8K4Q7
gene CERK
-
Mus musculus BALB/c
Q8K4Q7
gene CERK
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
macrophage
-
Mus musculus
-
MEF cell
primary mouse embryonic fibroblasts
Mus musculus
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ATP + ceramide
-
738824
Mus musculus
ADP + ceramide 1-phosphate
-
-
-
?
ATP + ceramide
-
738824
Mus musculus BALB/c
ADP + ceramide 1-phosphate
-
-
-
?
Cofactor
Cofactor
Commentary
Organism
Structure
ATP
-
Mus musculus
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
ATP
-
Mus musculus
Engineering (protein specific)
Amino acid exchange
Commentary
Organism
additional information
generation of CERK-/- knockout mice and enzyme silencing by siRNA
Mus musculus
Metals/Ions (protein specific)
Metals/Ions
Commentary
Organism
Structure
Mg2+
required
Mus musculus
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ATP + ceramide
Mus musculus
-
ADP + ceramide 1-phosphate
-
-
?
ATP + ceramide
Mus musculus BALB/c
-
ADP + ceramide 1-phosphate
-
-
?
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
macrophage
-
Mus musculus
-
MEF cell
primary mouse embryonic fibroblasts
Mus musculus
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ATP + ceramide
-
738824
Mus musculus
ADP + ceramide 1-phosphate
-
-
-
?
ATP + ceramide
-
738824
Mus musculus BALB/c
ADP + ceramide 1-phosphate
-
-
-
?
General Information
General Information
Commentary
Organism
malfunction
genetic ablation of CERK reduces basal ceramide 1-phosphate levels. CERK-/- knockout mouse cells show 52-74% reduced ceramide 1-phosphate contents and significantly lower levels of multiple eicosanoids compared to wild-type. Induction of eicosanoid synthesis by calcium ionophore is significantly reduced in the CERK-/- primary mouse embryonic fibroblasts. The CERK-/- mouse has adapted to loss of CERK in regards to airway hyper-responsiveness as compared with CERK siRNA treatment. Eicosanoids produced by immortalized primary mouse embryonic fibroblasts, overview
Mus musculus
physiological function
a role for ceramide kinase in the production of eicosanoids. The initial rate-limiting step in eicosanoid biosynthesis is started by the activation of group IVA phospholipase A, 2cPLA2alpha, which is activated by direct binding of the C2 domain to ceramide-1-phosphate
Mus musculus
General Information (protein specific)
General Information
Commentary
Organism
malfunction
genetic ablation of CERK reduces basal ceramide 1-phosphate levels. CERK-/- knockout mouse cells show 52-74% reduced ceramide 1-phosphate contents and significantly lower levels of multiple eicosanoids compared to wild-type. Induction of eicosanoid synthesis by calcium ionophore is significantly reduced in the CERK-/- primary mouse embryonic fibroblasts. The CERK-/- mouse has adapted to loss of CERK in regards to airway hyper-responsiveness as compared with CERK siRNA treatment. Eicosanoids produced by immortalized primary mouse embryonic fibroblasts, overview
Mus musculus
physiological function
a role for ceramide kinase in the production of eicosanoids. The initial rate-limiting step in eicosanoid biosynthesis is started by the activation of group IVA phospholipase A, 2cPLA2alpha, which is activated by direct binding of the C2 domain to ceramide-1-phosphate
Mus musculus
Other publictions for EC 2.7.1.138
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
737976
Payne
Ceramide kinase promotes tumor ...
Homo sapiens
Cancer Res.
74
6352-6363
2014
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1
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1
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1
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1
1
1
1
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738014
Pastukhov
Ceramide kinase contributes to ...
Mus musculus, Rattus norvegicus
Cell. Physiol. Biochem.
34
119-133
2014
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2
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2
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2
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4
4
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738825
Wijesinghe
Ceramide kinase is required fo ...
Homo sapiens, Mus musculus, Mus musculus BALB/c
J. Lipid Res.
55
1298-1309
2014
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3
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3
3
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738824
Mietla
Characterization of eicosanoid ...
Mus musculus, Mus musculus BALB/c
J. Lipid Res.
54
1834-1847
2013
-
-
-
-
1
-
-
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1
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2
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5
-
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2
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2
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1
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2
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2
2
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739165
Simanshu
Non-vesicular trafficking by a ...
Homo sapiens
Nature
500
463-467
2013
-
-
-
-
-
-
-
-
2
1
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1
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2
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1
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1
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1
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1
1
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723271
Bini
New signalling pathway involve ...
Homo sapiens
Neuropharmacology
63
524-537
2012
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2
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2
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2
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1
1
1
1
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699665
Murakami
ATRA inhibits ceramide kinase ...
Homo sapiens
J. Neurochem.
112
511-520
2010
-
-
-
-
-
-
1
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1
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3
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4
1
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4
1
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1
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1
1
1
1
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699827
Chen
Ceramide kinase profiling by m ...
Homo sapiens
J. Proteome Res.
9
420-429
2010
-
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1
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4
-
-
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1
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1
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1
1
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723681
Mitsutake
Ceramide kinase is not essenti ...
Mus musculus
Prostaglandins Other Lipid Mediat.
93
109-112
2010
-
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1
1
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696440
Rovina
Subcellular localization of ce ...
Homo sapiens
Biochim. Biophys. Acta
1791
1023-1030
2009
-
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1
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13
-
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6
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1
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1
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1
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13
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6
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1
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697229
Shimizu
Effects of ceramide, ceramidas ...
Homo sapiens
Cell. Signal.
21
440-447
2009
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1
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1
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1
1
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1
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699089
Ruckhaeberle
Gene expression of ceramide ki ...
Homo sapiens
J. Cancer Res. Clin. Oncol.
135
1005-1013
2009
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1
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2
1
1
2
-
-
700070
Niwa
Ceramide kinase deficiency imp ...
Mus musculus
Microvasc. Res.
77
389-393
2009
-
-
-
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1
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1
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2
2
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701002
Dasgupta
Ceramide kinase regulates phos ...
Drosophila melanogaster
Proc. Natl. Acad. Sci. USA
106
20063-20068
2009
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690404
Don
A fluorescent plate reader ass ...
Homo sapiens
Anal. Biochem.
375
265-271
2008
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690416
Graf
A secondary assay for ceramide ...
Homo sapiens
Anal. Biochem.
384(1)
166-169
2008
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1
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1
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691127
Lidome
A conserved cysteine motif ess ...
Homo sapiens
Biochimie
90
1560-1565
2008
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1
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5
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1
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1
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2
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691938
Lamour
Ceramide kinase and the cerami ...
Homo sapiens
Curr. Drug Targets
9
674-682
2008
1
1
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691965
Saxena
Ceramide kinase: a potential a ...
Homo sapiens
Curr. Opin. Investig. Drugs
9
455-462
2008
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12
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12
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1
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692307
Tsuji
Role of ceramide kinase in per ...
Mus musculus
FEBS J.
275
3815-3826
2008
1
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693223
Boath
Regulation and traffic of cera ...
Mus musculus
J. Biol. Chem.
283
8517-8526
2008
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1
1
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1
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693454
Graf
Neutropenia with impaired immu ...
Mus musculus
J. Immunol.
180
3457-3466
2008
-
1
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1
1
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1
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5
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7
5
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3
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1
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1
1
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1
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7
5
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3
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693522
Hinkovska-Galcheva
Ceramide kinase promotes Ca2+ ...
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2008
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694266
Graf
Targeting ceramide metabolism ...
Homo sapiens
Mol. Pharmacol.
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671789
Graf
Enhanced ceramide-induced apop ...
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354
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2007
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6
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672481
Van Overloop
On the presence of C2-ceramide ...
Homo sapiens
Biol. Chem.
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2007
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1
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673703
Mitra
Ceramide kinase regulates grow ...
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675274
Lamour
Ceramide kinase uses ceramide ...
Homo sapiens
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6
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690671
Munagala
Identification of small molecu ...
Homo sapiens
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2007
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690698
Mitsutake
The generation and behavioral ...
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2007
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690700
Van Overloop
Ceramide-dependent release of ...
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Kumada
Kinetics of the ceramide kinas ...
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2007
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3
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692594
Date
Ceramide kinase expression is ...
Homo sapiens
In Vitro Cell. Dev. Biol. Anim.
43
321-323
2007
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694006
Wijesinghe
Ceramide kinase and ceramide-1 ...
Homo sapiens
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265-292
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12
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662592
Van Overloop
Further characterization of ma ...
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Kim
The interaction between the pl ...
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2006
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671756
Inagaki
Identification of a nuclear lo ...
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671880
Rovina
A critical beta6-beta7 loop in ...
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661763
Kim
The leucine 10 residue in the ...
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The role of sphingosine and ce ...
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Mitsutake
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Wijesinghe
Substrate specificity of human ...
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Carre
Ceramide kinase targeting and ...
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Expression of ceramide kinase ...
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Mitsutake
Ceramide kinase is a mediator ...
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Bektas
A specific ceramide kinase ass ...
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Pettus
Ceramide kinase mediates cytok ...
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Sugiura
Ceramide kinase, a novel lipid ...
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