Application | Comment | Organism |
---|---|---|
medicine | CerK inhibition has potential for treating mesangioproliferative kidney diseases in humans | Mus musculus |
medicine | CerK inhibition has potential for treating mesangioproliferative kidney diseases in humans | Rattus norvegicus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | construction of CerK knockout cells | Mus musculus |
additional information | construction of CerK knockout cells | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
NVP-231 | inhibits enzyme catalysis | Mus musculus | |
NVP-231 | inhibits enzyme catalysis | Rattus norvegicus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | required | Mus musculus | |
Mg2+ | required | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + ceramide | Mus musculus | - |
ADP + ceramide 1-phosphate | - |
? | |
ATP + ceramide | Rattus norvegicus | - |
ADP + ceramide 1-phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q8K4Q7 | gene CERK | - |
Rattus norvegicus | D3Z9Y3 | gene CERK | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
fibroblast | renal | Mus musculus | - |
kidney | - |
Mus musculus | - |
kidney | - |
Rattus norvegicus | - |
mesangial cell | glomerular | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + ceramide | - |
Mus musculus | ADP + ceramide 1-phosphate | - |
? | |
ATP + ceramide | - |
Rattus norvegicus | ADP + ceramide 1-phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CERK | - |
Mus musculus |
CERK | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Mus musculus | |
ATP | - |
Rattus norvegicus |
General Information | Comment | Organism |
---|---|---|
malfunction | loss of CerK sensitized cells towards stress-induced apoptosis, loss of CerK facilitates apoptosis induced by stress factors such as staurosporine or TNFalpha combined with cycloheximide. Cell treatment with enzyme inhibitor NVP-231 decreases DNA synthesis, but not agonist-stimulated arachidonic acid release or PGE2 synthesis, overview | Rattus norvegicus |
malfunction | loss of CerK sensitized cells towards stress-induced apoptosis, loss of CerK facilitates apoptosis induced by stress factors such as staurosporine or TNFalpha combined with cycloheximide. Cell treatment with enzyme inhibitor NVP-231 decreases DNA synthesis, but not agonist-stimulated arachidonic acid release or PGE2 synthesis. Proliferation but not arachidonic acid release or PGE2 synthesis is reduced in CERK knockout cells, overview | Mus musculus |
physiological function | ceramide kinase catalyzes the generation of the sphingolipid ceramide-1-phosphate, which regulates various cellular functions including cell growth and death, and inflammation. Ceramide kinase contributes to proliferation but not to prostaglandin E2 formation in renal mesangial cells and fibroblasts | Mus musculus |
physiological function | ceramide kinase catalyzes the generation of the sphingolipid ceramide-1-phosphate, which regulates various cellular functions including cell growth and death, and inflammation. Ceramide kinase contributes to proliferation but not to prostaglandin E2 formation in renal mesangial cells and fibroblasts | Rattus norvegicus |