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Literature summary for 2.7.1.138 extracted from

  • Dasgupta, U.; Bamba, T.; Chiantia, S.; Karim, P.; Tayoun, A.N.; Yonamine, I.; Rawat, S.S.; Rao, R.P.; Nagashima, K.; Fukusaki, E.; Puri, V.; Dolph, P.J.; Schwille, P.; Acharya, J.K.; Acharya, U.
    Ceramide kinase regulates phospholipase C and phosphatidylinositol 4, 5, bisphosphate in phototransduction (2009), Proc. Natl. Acad. Sci. USA, 106, 20063-20068.
    View publication on PubMedView publication on EuropePMC
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Localization

Localization Comment Organism GeneOntology No. Textmining
plasma membrane
-
 Drosophila melanogaster 5886
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + ceramide Drosophila melanogaster ceramide is an important regulator of photoreceptor viability ADP + ceramide 1-phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Drosophila melanogaster
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + ceramide ceramide is an important regulator of photoreceptor viability Drosophila melanogaster ADP + ceramide 1-phosphate
-
 ?

Synonyms

Synonyms Comment Organism
ceramide kinase
-
 Drosophila melanogaster
CERK
-
 Drosophila melanogaster
DCERK protein
-
 Drosophila melanogaster

Expression

Organism Comment Expression
Drosophila melanogaster DCERK protein is expressed during all developmental stages additional information

General Information

General Information Comment Organism
malfunction a mutation in ceramide kinase specifically leads to proteolysis of NORPA, consequent loss of phosphoinositide-specific phospholipase C activity, and failure in light signal transduction, a significant increase in ceramide, resulting from lack of ceramide kinase, perturbs the membrane microenvironment of phosphatidylinositol-4,5-bisphosphate, altering its distribution Drosophila melanogaster
physiological function ceramide kinase, is a novel regulator of phosphoinositide-specific phospholipase C signaling and photoreceptor homeostasis, DCERK has a diacylglycerol kinase domain and a Ca2+/calmodulin binding domain Drosophila melanogaster