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Literature summary for 2.7.1.138 extracted from

  • Ruckhaeberle, E.; Karn, T.; Rody, A.; Hanker, L.; Gaetje, R.; Metzler, D.; Holtrich, U.; Kaufmann, M.
    Gene expression of ceramide kinase, galactosyl ceramide synthase and ganglioside GD3 synthase is associated with prognosis in breast cancer (2009), J. Cancer Res. Clin. Oncol., 135, 1005-1013.
    View publication on PubMed

Application

Application Comment Organism
diagnostics putative prognostic marker in breast cancer, estrogen receptor negative patients with high ceramide kinase expression had a worse prognosis then those with low expression Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + ceramide Homo sapiens
-
ADP + ceramide 1-phosphate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
breast cancer cell tissue samples of primary invasive breast cancer cases Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + ceramide
-
Homo sapiens ADP + ceramide 1-phosphate
-
?

Synonyms

Synonyms Comment Organism
ceramide kinase
-
Homo sapiens
CERK
-
Homo sapiens

Expression

Organism Comment Expression
Homo sapiens ceramide kinase expression shows no association with age, lymph node status and tumor size additional information
Homo sapiens higher expression in estrogen receptor negative breast tumors, gene expression of ceramide kinase is associated with prognosis in breast cancer, high ceramide kinase expression is correlated with ErbB2 status up

General Information

General Information Comment Organism
metabolism sphingolipid metabolism Homo sapiens